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GlossaryIntrinsic Aging

natural aging process driven by genetic and biological factors

Intrinsic aging, also known as chronological aging, refers to the natural and inevitable process of aging that occurs over time due to genetic and biological factors. This type of aging affects all organs, including the skin and hair, leading to changes such as thinning hair, reduced skin elasticity, and the appearance of fine lines and wrinkles. Unlike extrinsic aging, which is influenced by external factors like sun exposure and pollution, intrinsic aging is driven by the body's internal biological clock.

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research Quantitative morphometric analysis of intrinsic and extrinsic skin ageing in individuals with Fitzpatrick skin types II–III

4 citations , January 2023 in “Experimental dermatology”

Skin thickness decreases and structural changes occur with both ageing and sun exposure in certain skin types.

Intrinsic Versus Extrinsic Aging: A Histopathological, Morphometric, and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor

research Intrinsic versus Extrinsic Aging: A Histopathological, Morphometric and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor

9 citations , January 2016 in “Skin Pharmacology and Physiology”

The study concluded that both estrogen and androgen receptors, which decrease with age, are linked to skin aging and may be hormonally regulated.

research Aging in the Male Face: Intrinsic and Extrinsic Factors

27 citations , May 2016 in “Dermatologic Surgery”

Male faces age with more wrinkles and hair loss, influenced by both body changes and environmental factors.

Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

research 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.

research Skin connective tissue and ageing

77 citations , July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

research The lack of significant changes in scalp hair follicle density with advancing age

33 citations , April 2005 in “British Journal of Dermatology”

Aging alone barely affects the number of hair follicles, meaning hair loss is minimal without other conditions like androgenetic alopecia.

research Characteristic features of ageing in Korean women’s hair and scalp

31 citations , December 2012 in “British Journal of Dermatology”

Korean women's hair thins, weakens, and greys with age, with mineral and sterol changes.

research Skin aging: are adipocytes the next target?

70 citations , July 2016 in “Aging”

Targeting dermal adipocytes may help combat skin aging.

research Pathological and Immunohistochemical Assessment of Aging of the Abdominal Skin Treated with Carboxytherapy: A Randomized, Split-body Trial.

1 citations , August 2024 in “PubMed”

Carboxytherapy can improve and reverse aging skin.

research 516 Intrinsic factors regulating hair growth: insights into growth factors, cytokines, chemokines, and interferons

November 2024 in “Journal of Investigative Dermatology”

Red ginseng components help prevent skin aging by reducing inflammation and improving cell function.

research The Skin Microbiome: Current Landscape and Future Opportunities

114 citations , February 2023 in “International Journal of Molecular Sciences”

The skin microbiome is crucial for skin health, and more research is needed to explore its role and potential treatments.

New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today's Pre-Clinical Data into Tomorrow's Daily Clinical Practice

research New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today’s Pre-Clinical Data into Tomorrow’s Daily Clinical Practice

16 citations , July 2012 in “Current pharmaceutical biotechnology”

New treatments for skin conditions related to the sebaceous gland are being developed based on current research.

research Haut und Haar

1 citations , December 2005 in “Therapeutische Umschau”

The document concludes that protecting skin from the sun, avoiding smoking, and using treatments like Minoxidil and Finasteride can help manage skin and hair aging.

research SKIN AND HAIR CHANGES AFTER FORTY

April 2014 in “Journal of evolution of medical and dental sciences”

Women over forty can maintain skin and hair health with lifestyle and dietary changes.

research Dermatologic Problems of Older Women

17 citations , April 2006 in “Dermatologic Clinics”

Older women face various skin issues like dryness and thinning, and treatments are available but can have side effects; proper skin care and legal health decisions are important.

The Use of Vegetable Oils in Preventing Skin Aging

research O uso dos óleos vegetais na prevenção do envelhecimento da pele

1 citations , January 2021 in “Research, Society and Development”

Vegetable oils rich in antioxidants may help prevent skin aging caused by free radicals.

research 1340 Basal keratinocytes exhibit age-related epigenetic and transcriptomic alterations resulting in an altered metabolic profile

April 2023 in “Journal of Investigative Dermatology”

Aging changes skin cells, leading to different DNA methylation and gene activity, affecting cell metabolism and aging signs.

research Geriatric Dermatology: Overview

May 2013 in “Springer eBooks”

Skin problems in the elderly are unique and may indicate other diseases, involving changes in skin, hair, nails, and increased cancer risk.

research The exposome impact on hair health: non-pharmacological management. Part II⋆

1 citations , January 2025 in “Anais Brasileiros de Dermatologia”

Non-drug methods can help protect hair from damage caused by genetics, UV rays, and pollution.

research Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair

160 citations , July 2008 in “Experimental dermatology”

Melatonin protects the skin by scavenging free radicals and repairing DNA damage.

research 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs

July 2024 in “Journal of Investigative Dermatology”

Bioengineered skin models aging well, useful for studying aging and testing treatments.

research LncRNA-miRNA-mRNA regulatory networks in skin aging and therapeutic potentials

3 citations , October 2023 in “Frontiers in physiology”

ceRNA networks offer potential treatments for skin aging and wound healing.

research Clinical and Sonographic Assessment of Carboxytherapy Efficacy in Treatment of Skin Aging: A 2-split Randomized Clinical Trial.

November 2024 in “PubMed”

Carboxytherapy effectively and safely improves skin aging signs.

research Aging Skin: A Window to the Body

1 citations , April 2016 in “CRC Press eBooks”

Skin aging reflects overall body aging and can indicate internal health conditions.

research The Pathobiology of Skin Aging

122 citations , April 2020 in “American Journal Of Pathology”

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

research The Future of Topical Therapy for Cutaneous Aging

11 citations , October 1990 in “The Journal of dermatologic surgery and oncology”

New treatments for skin aging will soon compete with current ones like tretinoin.

research The Aging Face

22 citations , September 2018 in “Medical Clinics of North America”

Facial aging is caused by natural processes and external factors, and can be managed with preventative measures and a variety of treatments tailored to individual needs.