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research Monilethrix: A Novel Mutation (Glu402Lys) in the Helix Termination Motif and the First Causative Mutation (Asn114Asp) in the Helix Initiation Motif of the Type II Hair Keratin hHb6

29 citations , August 1999 in “Journal of Investigative Dermatology”

New mutations in hair keratin genes cause the rare hair disorder monilethrix.

research Localization and Expression of Cornifin-α/SPRR1 in Mouse Epidermis, Anagen Follicles, and Skin Neoplasms

26 citations , April 1996 in “Journal of Investigative Dermatology”

research Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture

38 citations , March 1997 in “Journal of interferon & cytokine research”

IL-1β inhibits human hair follicle growth.

research The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71

75 citations , October 2010 in “Mammalian genome”

Sphynx cats are hairless and Devon Rex cats have curly hair due to specific genetic mutations.

research DNMT1 targets SRD5A2 to induce mitochondrial homeostasis and EMT in urothelial cells of hypospadias

April 2025 in “Molecular Biology Reports”

DNMT1 may help treat hypospadias by improving cell function and preventing unwanted cell changes.

research Identification of Trichohyalin-Like 1, an S100 Fused-Type Protein Selectively Expressed in Hair Follicles

27 citations , May 2011 in “Journal of Investigative Dermatology”

TCHHL1 is a protein important for hair growth, found in hair follicles.

research Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes

70 citations , March 2010 in “The Journal of Steroid Biochemistry and Molecular Biology”

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

research Mechanism of action of NLRP3 protein macromolecule based on electrochemical sensors in the treatment of alopecia areata in mice: The role of Ritlecitinib in AA mice through NLRP3

March 2026 in “Microchemical Journal”

research Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity

372 citations , December 2004 in “Nature Genetics”

research Template‐directed self‐assembly and growth of insulin amyloid fibrils

36 citations , March 2005 in “Biotechnology and Bioengineering”

A new method speeds up insulin amyloid fibril growth, useful for studying diseases.

Forsythiaside A Protects Against Focal Cerebral Ischemic Injury by Mediating the Activation of the Nrf2 and Endoplasmic Reticulum Stress Pathways

research Forsythiaside A protects against focal cerebral ischemic injury by mediating the activation of the Nrf2 and endoplasmic reticulum stress pathways

12 citations , May 2019 in “Molecular Medicine Reports”

Forsythiaside A helps reduce brain damage from lack of blood flow by activating certain protective pathways.

research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

451 citations , March 2005 in “Endocrine Reviews”

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

research 496 Understanding the mechanism of action of secukinumab using lesional hidradenitis suppurativa skin organ culture

November 2024 in “Journal of Investigative Dermatology”

Secukinumab reduces immune activity in hidradenitis suppurativa skin.

Ionizing Radiation Triggers Dedifferentiation of Outer Root Sheath Cells Into Stem Cell-Like Progenitors for Hair Follicle Regeneration

research 881 Ionizing radiation triggers dedifferentiation of outer root sheath cells into stem cell-like progenitors for hair follicle regeneration

April 2017 in “Journal of Investigative Dermatology”

research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

48 citations , March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Retinoic acid production and signaling in hair follicles are regulated by location and timing, affecting hair growth and cycling.

research Author response: ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas

November 2015

ETS2 is crucial in squamous cell carcinoma development and could be a therapeutic target.

research Immunohistochemical expressions of mGluR5, P2Y2 receptor, PLC-?1, and IP3R-I and -II in Merkel cells in rat sinus hair follicles

32 citations , July 2003 in “Histochemistry and Cell Biology”

research Solubilization and Solid‐State Characterization of a Poorly Soluble 5‐α Reductase Inhibitor

January 2004 in “Drug Development and Industrial Pharmacy”

GI197111X is best dissolved in Capmul MCM for trials.

research Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest it Evolved from Keratinocyte Keratins.

238 citations , May 1989 in “Journal of Investigative Dermatology”

research The KRAB domain zinc finger protein, Zfp157, is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin

8 citations , January 2013 in “genesis”

Zfp157 is active in many mouse tissues during development and in specific adult cells.

research Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis

70 citations , December 2008 in “Cancer Research”

CXCR2 in skin cells promotes tumor growth.

research MITF E318K naevus phenotype: the modifying role of MC1R Red Hair Variants

March 2026 in “Journal of Investigative Dermatology”

research Progressive alopecia areata during TNF-α inhibition with intralesional corticosteroid failure and subsequent improvement following JAK1 inhibition

1 citations , May 2026 in “Journal of Dermatological Treatment”

JAK1 inhibitor may effectively treat alopecia areata when TNF-α inhibitors and corticosteroids fail.

research ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability

8 citations , July 2023 in “Inflammation and Regeneration”

ALKBH5 helps wounds heal faster by stabilizing PELI2 mRNA.

PSS20 Mediation Modeling and Measurement Characteristics of the Itch Severity Score from a Phase 2B Trial of Oral CP-690-550 in Patients with Moderate-to-Severe Plaque Psoriasis

research PSS20 MEDIATION MODELING AND MEASUREMENT CHARACTERISTICS OF THE ITCH SEVERITY SCORE FROM A PHASE 2B TRIAL OF ORAL CP-690-550 IN PATIENTS WITH MODERATE TO-SEVERE PLAQUE PSORIASIS

May 2011 in “Value in Health”

CP-690,550 significantly reduced itching in patients with moderate-to-severe plaque psoriasis.

research ROOT HAIR DEFECTIVE SIX‐LIKE4 (RSL4) promotes root hair elongation by transcriptionally regulating the expression of genes required for cell growth

75 citations , July 2016 in “New phytologist”

The protein RSL4 is crucial for making root hairs longer by controlling genes related to cell growth.

research Human Epidermal Transglutaminase

53 citations , June 1983 in “Journal of Investigative Dermatology”

The enzyme is crucial for skin cell development and can be activated without proteolytic activation.

research Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands

April 2026 in “Figshare”

As people age, certain enzymes in scalp glands decrease, affecting hair health.

research Isolation and Molecular Cloning of Epidermal- and Hair Follicle-Specific Peptidylarginine Deiminase (Type III) from Rat

42 citations , May 1997 in “The Journal of Biochemistry”

PAD type III enzyme is specific to rat skin and hair follicles.

research Alterations in transcriptome and antioxidant activity of naturally aged mice exposed to selenium-rich rice

10 citations , April 2019 in “Environmental Science and Pollution Research”

Eating selenium-rich rice improved antioxidant activity and signs of aging in mice.

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