research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase
New compounds were made that block an enzyme linked to breast cancer better than existing treatments.
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research Post severe COVID-19 infection lung damages study. The experience of early three months multidisciplinary follow-up
After severe COVID-19, lung damage can improve, detected effectively by lung-ultrasound, and high pressure support during hospitalization can increase lung artery size. Also, about 22% of patients had lung blood clots, and when treated, they recovered faster.
research Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata
SCD-153 shows promise as an effective topical treatment for alopecia areata.
research Lichen planus – A refractory autoimmune disorder
Lichen planus is a chronic autoimmune disease that is hard to treat and more common in women.
research The Long-Term Effect Of Specific Type II 5α-Reductase Inhibition With Finasteride on Bone Mineral Density in Men: Results of a 4-Year Placebo Controlled Trial
Finasteride doesn't harm bone density in older men with BPH.
research Properties of Partially Extracted Hairs and their Degradability by Proteases
Mf-rich hair degrades more than Ma-rich hair, especially with Proteinase K.
research Effect of K+ channel openers on K+ channel in cultured human dermal papilla cells.
Increased K+ permeability alone may not promote hair growth.
research Immune-related alopecia (areata and universalis) in cancer patients receiving immune checkpoint inhibitors
Cancer patients treated with immune checkpoint inhibitors may develop alopecia, but some hair regrowth is possible with treatment.
research Differential inhibition by tedisamil (KC 8857) and glibenclamide of the responses to cromakalim and minoxidil sulphate in rat isolated aorta
Tedisamil and glibenclamide affect cromakalim and minoxidil sulphate differently in rat aorta.
research Renal Vitamins
Dialysis patients benefit from water-soluble vitamins but need careful management to avoid risks.
research The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim
Diazoxide, minoxidil sulphate, and cromakalim relax rat blood vessels by opening K+ channels, with some differences in their actions.
research Acute sensitivity of the oral mucosa to oncogenic K‐ras
Oncogenic K-ras causes rapid cancerous changes in the mouth's lining.
research Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases
Ginsenoside compound K shows promise for treating metabolic diseases like obesity and diabetes, but more research is needed on its safety and effectiveness.
research 15. Hair and Nails
Hair and nail conditions can stabilize or improve over time, and new treatments show promise.
research Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases
Ginsenoside compound K shows promise for treating metabolic diseases like diabetes and obesity.
research Oral Manifestations of Hematologic and Nutritional Diseases
Recognizing oral symptoms can help diagnose and treat blood and nutritional diseases early.
research Studying the genetic predisposing factors in the pathogenesis of acne vulgaris
Genetics play a role in acne, but how exactly they contribute is not fully understood.
research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action
Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.
research Reactivation of Alopecia Areata After Dupilumab Therapy for Atopic Dermatitis
Dupilumab for skin problems might reactivate hair loss in some patients.
research Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp
Minoxidil promotes hair growth but exact mechanism is unknown.
research A Potential Role for IL-4 and IL-13 in an Alopecia Areata–Like Phenotype: A Clinical Perspective
IL-4 and IL-13 might play a role in a type of hair loss similar to alopecia areata.
research 947 Accelerating wound healing mechanisms with cold atmospheric plasma
Cold atmospheric plasma may speed up wound healing and control infections.
research A partially automated method for DNA extraction from marmoset hair follicles to avoid blood chimerism
The method effectively extracts high-quality DNA from marmoset hair, avoiding blood chimerism.
research Research on Mental Stress Recognition of Depressive Disorders in Patients With Androgenic Alopecia Based on Machine Learning and Fuzzy K-Means Clustering
The FAW-FS algorithm improves depression recognition, and psychological interventions help AGA patients' mental health.
research KCNQ4 K+ channels tune mechanoreceptors for normal touch sensation in mouse and man
research Dupilumab: A Review of Present Indications and Off-Label Uses
Dupilumab is being tested for many new skin, respiratory, and gastrointestinal conditions.
research Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for their Modes of Action in Hair Follicles
Potassium channel openers like minoxidil help hair grow by acting on hair follicles.
research Novel inhibitors of 5α-reductase
New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.
research Basic mechanisms of SARS-CoV-2 infection. What endocrine systems could be implicated?
SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.
research Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes
A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.