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GlossaryKeratin 35

protein crucial for hair and nail structure and strength

Keratin 35 (KRT35) is a type of protein found in the hair and nails, playing a crucial role in their structure and strength. It is part of the keratin family, which are fibrous structural proteins essential for the mechanical integrity and protective functions of epithelial cells.

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iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

research iTRAQ-based quantitative proteomics revealing the therapeutic mechanism of a medicinal and edible formula YH0618 in reducing doxorubicin-induced alopecia by targeting keratins and TGF-β/Smad3 pathway

June 2024 in “Heliyon”

YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

research Dyeing behaviours of amino heterocyclic compounds as blue oxidative hair dye precursors applied to keratin fibres

5 citations , January 2011 in “International Journal of Cosmetic Science”

1,2,3,4-tetrahydroquinoline compounds are great for stable, pure blue hair dye.

research Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy

10 citations , January 2010 in “International journal of trichology”

Keratin-associated proteins are part of the developing hair fiber cuticle.

DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

research DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

3 citations , January 2023 in “Science advances”

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

research Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology

33 citations , February 2012 in “British Journal of Dermatology”

Mutations in the p63 gene affect skin adhesion, barrier integrity, and hair growth.

research Expression of truncated latent TGF-β-binding protein modulates TGF-β signaling

40 citations , May 2005 in “Journal of Cell Science”

Truncated LTBP-1 disrupts TGF-β signaling, affecting hair growth.

Towards Developing an Organotypic Model for the Preclinical Study and Manipulation of Human Hair Matrix-Dermal Papilla Interactions

research Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactions

4 citations , January 2021 in “Archives of dermatological research”

The study created a new model to better understand human hair growth and health.

Dissecting the Role of the Common Neurotrophin Receptor CD271 in the Skin: Generation and Characterization of a Novel Mouse Model with Keratinocyte-Specific Conditional Deletion

research 186 Dissecting the role of the common neurotrophin receptor CD271 in the skin: generation and characterization of a novel mouse model with keratinocyte-specific conditional deletion

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Deleting the CD271 gene in mouse skin cells leads to disorganized skin and increased hair growth, suggesting CD271 is important for skin health.

research Differentiation of the basal cell epithelioma-like changes overlying dermatofibroma.

12 citations , January 1991 in “Acta Dermato Venereologica”

Basal cell epithelioma-like changes are most similar to normal basal cells.

research The Gross Morphology and Scanning Electron Microscopic Evaluation of the Skin Surface in Congenic Strains of Hairless Mice

January 2005 in “Chinese Journal of Veterinary”

Hairless mice lose hair by 3-4 weeks, develop thicker, folded skin, and show pigmentation differences.

research A Dermoscopic Clue for the Diagnosis of Traction Alopecia: Peripilar Keratin Casts: Case Report

January 2015 in “Turkiye Klinikleri Journal of Dermatology”

Peripilar keratin casts are a helpful sign for diagnosing traction alopecia.

Cachexia and Graft-Versus-Host Disease-Type Skin Changes in Keratin Promoter-Driven TNF Alpha Transgenic Mice

research Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.

150 citations , August 1992 in “Genes & Development”

TNF alpha in skin cells causes weight loss, hair and fat issues, and skin inflammation in mice.

research Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits

42 citations , January 2017 in “Genes”

The gene KAP22-1 affects wool yield and fiber shape in sheep.

research Reactive keratin derivatives: A promising strategy for covalent binding to hair

20 citations , September 2018 in “Journal of colloid and interface science”

Modified keratin binds better to hair, especially bleached hair.

research Crosslinking structure of keratin. V. Number and type of crosslinks in microstructures of untreated and potassium cyanide treated human hair

11 citations , September 1996 in “Journal of applied polymer science”

Potassium cyanide treatment changes hair's disulfide bonds, making it more elastic.

Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth in a Randomized Clinical Trial

research Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial

27 citations , September 2017 in “Journal of Medicinal Food”

Annurca apple supplement safely increases hair growth and keratin in humans.

research Repair of damaged hair protein fiber by jointly using transglutaminase and keratin

3 citations , January 2021 in “ScienceAsia”

Using an enzyme and keratin treatment can significantly repair and strengthen damaged hair.

research Crosslinking structure of keratin. V. Number and type of crosslinks in microstructures of untreated and potassium cyanide treated human hair

2 citations , September 1996 in “Journal of Applied Polymer Science”

Potassium cyanide changes hair's disulfide bonds to monosulfide, affecting high-sulfur proteins more.

research Production of Anti-Hair Keratin Antibody and Its Characteristics: Utilization of Cow Colostrum and Milk

2 citations , January 1994 in “Nihon Chikusan Gakkaiho”

Cow colostrum and milk can effectively produce anti-hair keratin antibodies.

research CosmeticPotential of a Structural Protein CopolymerBased on Silk, Elastin, and Keratin

September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

SELP::KP improves hair strength, elasticity, and health, making it a promising hair cosmetic.

research Preparation and Characterization of Soluble Wool Keratin for Human Hair Care

January 2013 in “Transactions of the Materials Research Society of Japan”

CMADK reduces hair damage from bleaching and permanent waving.

research ALOPECIA AREATA PROFILING SHOWS LNCRNAS REGULATE THE SUPPRESSED EXPRESSION OF KERATIN.

September 2024 in “PubMed”

Certain RNAs may help diagnose alopecia areata by affecting keratin genes.

Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

research 1322 Molecular profiling of frontal fibrosing alopecia (FFA) reveals TH1 and JAK-STAT up-regulation with no suppression of hair keratins

2 citations , April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

research Mapping of monilethrix to the type II keratin gene cluster at chromosome 12q13 in three new families, including one with variable expressivity

21 citations , September 1997 in “British Journal of Dermatology”

Monilethrix is linked to the type II keratin gene on chromosome 12q13.

research Molecular elements of the regulatory control of keratin filament modulator AHF/trichohyalin in the hair follicle

7 citations , July 2008 in “Experimental Dermatology”

The study concluded that a protein important for hair strength is regulated by certain molecular processes and is affected by growth phases.

research Polymorphism of keratin-associated protein (KAP) 7 gene and its association with wool traits in Rambouillet sheep

3 citations , May 2018 in “The Indian Journal of Animal Sciences”

The KAP 7 gene affects wool traits in Rambouillet sheep, with the BB genotype showing the best wool characteristics.

Efficacy and Safety of L-Cystine Associated or Not to a Natural Keratin (Kera-Diet) Hydrolysate on Hair and Nails: Randomized, Placebo-Controlled, Clinical Trial on Healthy Females

research Efficacy and Safety of L-Cystine Associated or not to a Natural Keratin (Kera-Dietandreg;) Hydrolysate on Hair and Nails: Randomised, Placebo-Controlled, Clinical Trial on Healthy Females

January 2019 in “Journal of cosmetology & trichology”

L-Cystine and L-Cystine with Kera-Diet® safely improved hair and nail quality in healthy women.

Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

research Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)

May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.

research Immunological characteristics and histological distribution of human hair fibrous proteins studied with anti-hair keratin monoclonal antibodies HKN-2, HKN-4, and HKN-6.

52 citations , February 1986 in “Journal of Histochemistry & Cytochemistry”

Some hair proteins are specific to hair, while others are also found in skin cells.

research UNCONVENTIONAL PROTEIN SECRETION OF KERATIN 75 BY AMELOBLASTS IN VIVO

April 2018 in “D-Scholarship@Pitt (University of Pittsburgh)”

Keratin-75 is secreted by ameloblasts in a unique way without a signal peptide.