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GlossaryKeratin 85

protein crucial for hair structure and strength

Keratin 85, also known as KRT85, is a type of protein found in hair follicles. It plays a crucial role in the structure and strength of hair, contributing to its resilience and elasticity. Mutations in the KRT85 gene can lead to hair disorders, such as monilethrix, which is characterized by beaded or fragile hair.

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Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity

research Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity

November 2023 in “Advanced Science”

A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.

research Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody

3 citations , August 2018 in “Journal of Structural Biology”

KAP8.1 protein is crucial for hair structure and interacts with keratin 85.

research Study on kerantin association protein 8.1 gene expression of Liaoning cashere goats in skin and hair follicle

January 2014 in “China Feed”

Higher expression of the keratin-associated protein 8.1 gene in Liaoning cashmere goats is linked to finer cashmere fibers.

research Study on Differential Expression of Keratin Associated Protein 8-1 Gene of Different Varieties of Ovis aries in Skin and Hair Follicle

January 2014 in “China Animal Husbandry & Veterinary Medicine”

The KAP8-1 gene affects skin, hair follicle development, and wool quality in different sheep varieties.

research Abstract 5022: Keratin15 (Krt15) + are radio resistant and tumor-initiating cells in the mouse small intestine

July 2017 in “Cancer Research”

Krt15+ cells in mice can resist radiation, regenerate tissue, and start tumors, suggesting new cancer treatment targets.

iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

research iTRAQ-based quantitative proteomics revealing the therapeutic mechanism of a medicinal and edible formula YH0618 in reducing doxorubicin-induced alopecia by targeting keratins and TGF-β/Smad3 pathway

June 2024 in “Heliyon”

YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

research Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology

33 citations , February 2012 in “British Journal of Dermatology”

Mutations in the p63 gene affect skin adhesion, barrier integrity, and hair growth.

research Corneal epithelial‐like transdifferentiation of hair follicle stem cells is mediated by pax6 and β‐catenin/Lef‐1

20 citations , April 2009 in “Cell Biology International”

Hair follicle stem cells can become corneal-like cells with the help of pax6.

research Lineage Tracing of Hair Follicle Stem Cells in Epidermal Whole Mounts

11 citations , January 2013 in “Methods in molecular biology”

The method allows for 3D tracking of hair follicle stem cells and shows they can regenerate hair for up to 180 days.

Dissecting the Role of the Common Neurotrophin Receptor CD271 in the Skin: Generation and Characterization of a Novel Mouse Model with Keratinocyte-Specific Conditional Deletion

research 186 Dissecting the role of the common neurotrophin receptor CD271 in the skin: generation and characterization of a novel mouse model with keratinocyte-specific conditional deletion

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Deleting the CD271 gene in mouse skin cells leads to disorganized skin and increased hair growth, suggesting CD271 is important for skin health.

research 1373 Specific in vivo ablation of Lrig1-positive follicular stem cells results in sebaceous gland loss in mice

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Removing Lrig1-positive stem cells in mice causes temporary loss of sebaceous glands.

Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

research Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)

May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.

research Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits

42 citations , January 2017 in “Genes”

The gene KAP22-1 affects wool yield and fiber shape in sheep.

Association of the KAP 8.1 Gene Polymorphisms with Fiber Traits in Inner Mongolian Cashmere Goats

research Association of the KAP 8.1 Gene Polymorphisms with Fibre Traits in Inner Mongolian Cashmere Goats

12 citations , August 2011 in “Asian-Australasian Journal of Animal Sciences”

KAP8.1 gene variations affect cashmere weight in Inner Mongolian goats.

research Psoriasiform skin reaction due to Brazilian keratin treatment

2 citations , May 2022 in “International Journal of Trichology”

Brazilian Keratin Treatment can cause skin reactions like redness and scaling, possibly due to formaldehyde.

research Comparative genomics analyses of alpha-keratins reveal insights into evolutionary adaptation of marine mammals

25 citations , August 2017 in “Frontiers in Zoology”

Marine mammals lost many α-keratin genes, aiding their adaptation to aquatic life by becoming hairless.

research Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2

22 citations , August 2015 in “PloS one”

Keratin from hair binds well to gold and BMP-2, useful for bone repair.

research Repair of damaged hair protein fiber by jointly using transglutaminase and keratin

3 citations , January 2021 in “ScienceAsia”

Using an enzyme and keratin treatment can significantly repair and strengthen damaged hair.

research Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch

8 citations , August 2014 in “Biochemical and Biophysical Research Communications”

ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.

Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes

research The Binding of Small Molecules and Polymers to Keratin and Their Effects on the Physicochemical and Surface Properties of Hair Fibers

7 citations , January 1981 in “Springer eBooks”

Certain small molecules and polymers can change hair's physical properties and how it feels by affecting the bonds within the hair.

research Ribonucleic Acids Coding for the Keratin Complex of Hair

5 citations , January 1981

Keratin proteins in hair are complex and come from multiple gene families.

research Delayed-onset pachyonychia congenita caused by a novel mutation in the V2 domain of keratin 6b

4 citations , December 2013 in “The Journal of Dermatology”

A new mutation in the K6b gene caused a girl's late-appearing nail condition.