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GlossaryKeratin

protein forming hair, nails, and skin's outer layer

Keratin is a type of protein that forms the structural foundation of hair, nails, and the outer layer of skin. It provides strength and protection, making these tissues resilient and less prone to damage. In hair, keratins are essential for maintaining its integrity and elasticity, and they play a crucial role in the hair's overall health and appearance.

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research Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777]

1 citations , November 2012 in “European Journal of Cell Biology”

The authors clarified data overlap and corrected a figure error, apologizing for any confusion.

research Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons

419 citations , March 2005 in “Proceedings of the National Academy of Sciences”

Hair-follicle stem cells can become neurons.

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

387 citations , November 2003 in “Journal of Investigative Dermatology”

The K15 promoter effectively targets stem cells in the hair follicle bulge.

research Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes

198 citations , March 1999 in “Journal of Investigative Dermatology”

Keratin 15 helps maintain tissue integrity and is reduced in activated keratinocytes.

research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

192 citations , April 2019 in “ACS nano”

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

research Keratin K15 as a Biomarker of Epidermal Stem Cells

85 citations , September 2013 in “International Journal of Molecular Sciences”

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain

70 citations , December 2004 in “Differentiation”

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

research Structural change of keratin protein in human hair by permanent waving treatment

70 citations , June 1998 in “Polymer”

Permanent waving damages hair by disrupting its keratin structure.

research Prolactin—a novel neuroendocrine regulator of human keratin expressionin situ

64 citations , January 2010 in “The FASEB Journal”

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

research Expression of the hair stem cell-specific keratin 15 in pilar tumors of the skin.

54 citations , September 1999 in “PubMed”

K15 staining helps distinguish basal cell carcinoma from trichoepithelioma.

research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

53 citations , September 1999 in “The journal of cell biology/The Journal of cell biology”

K16 can partially replace K14 but causes hair loss and skin issues.

research Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle

46 citations , November 1998 in “Experimental Cell Research”

K15 gene is mainly active in the basal layers of hair follicles and epithelia, aiding early skin cell development.

research A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse

44 citations , March 2012 in “Molecular Carcinogenesis”

Keratin 15 cells from hair follicles help develop and maintain skin tumors in mice.

research Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro

42 citations , July 2010 in “European Journal of Cell Biology”

Thyroid hormones affect hair follicle stem cells by promoting differentiation and reducing growth.

research Keratin intermediate filaments in the colon: guardians of epithelial homeostasis

38 citations , November 2020 in “International journal of biochemistry & cell biology”

Keratin proteins are essential for keeping the cells in the human colon healthy and stable.

research Keratin Expression Provides Novel Insight into the Morphogenesis and Function of the Companion Layer in Hair Follicles

38 citations , December 2006 in “Journal of Investigative Dermatology”

Keratin patterns in hair follicles help understand hair growth and potential hair and nail disorders.

research Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling

35 citations , June 2012 in “PloS one”

Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.

research Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia

28 citations , June 2012 in “International Journal of Molecular Medicine”

Radiation damages hair stem cells and changes keratin expression, with Krt5 as a potential marker for radiation effects.

Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

research Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

18 citations , October 2018 in “Nutrients”

Annurca apple extract promotes hair growth by changing hair follicle metabolism to boost keratin production.

research Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage

441 citations , May 1996 in “Journal of Cell Science”

Keratin 19 helps identify skin stem cells, with its presence varying by body location, age, and culture stage.