research Keratins and skin disease
Keratin mutations cause skin diseases and could lead to new treatments.
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420-450 / 1000+ resultsresearch Autophagy-Mediated Cellular Remodeling during Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages
Autophagy is essential for proper skin cell development and function.
research Nuclear Topology, Epigenetics, and Keratinocyte Differentiation
Nuclear shape and chromatin changes affect gene expression in skin cell differentiation.
research Histochemical studies on cutaneous stem cells in human fetal skin
Basal layer skin cells help form the epidermis and hair follicles.
research Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins
research In this Issue
New findings on hair keratin, wound healing, and skin blistering were presented.
research Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin
Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.
research Keratin Biomaterials Activate Schwann Cells via Integrin‐Mediated Signaling and Promote Regeneration of Large Peripheral Nerve Defects in a Rabbit Model
Keratin biomaterials from human hair help nerve regeneration by activating Schwann cells.
research Two- and Three-Dimensional Culture of Keratinocyte Stem and Precursor Cells Derived from Primary Murine Epidermal Cultures
research A single type of progenitor cell maintains normal epidermis
One type of progenitor cell can maintain normal skin in mice.
research Trichilemmoma.Cell biology of the normal human outer root sheath.
The outer root sheath in hair follicles changes during growth, with different keratinization processes in its layers.
research Regular expression of hair follicle keratins as crucial factors in tissue engineering of hair follicles
Keratins are key to developing and regenerating hair follicles for treating hair loss.
research Structure and functions of human hair keratin
research Establishment of a new three‐dimensional human epidermal model reconstructed from plucked hair follicle‐derived keratinocytes
A new skin model from hair follicles is a safer, simpler alternative for skin tests.
research BMP4 and nuclear laminC orchestrate a expression of AHF/Trichohyalin molecule, a key modulator of keratin intermediate filaments in the hair follicle
research Keratin expression in basal cell carcinomas
Basal cell carcinomas likely originate from hair follicle cells or stem cells.
research Immunohistochemical demonstration of keratins in the epidermal layers of the Malayan pangolin (Manis javanica), with remarks on the evolution of the integumental scale armour
Keratins in Malayan pangolins vary by region, suggesting scales evolved from the tail towards the head.
research Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis
Keratin 15 helps maintain skin cell growth and repair.
research Distribution of keratin and associated proteins in the epidermis of monotreme, marsupial, and placental mammals
Monotreme and marsupial skin proteins show primitive features and species-specific differences compared to placental mammals.
research Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy
Keratin-associated proteins are part of the developing hair fiber cuticle.
research Deriving Keratinocyte Progenitor Cells and Keratinocytes from Human‐Induced Pluripotent Stem Cells
Scientists developed a way to create skin and hair cells from human stem cells, which could help treat burns and restore hair.
research Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development
Ezh2 controls skin development by balancing signals for dermal and epidermal growth.
research The Immune Functions of Keratinocytes in Skin Wound Healing
Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
research LB1081 Three-dimensional imaging of tight junction-network across multiple layers of human epidermis by array tomography using backscattered electron-mode scanning electron microscopy
The study found that tight junctions reach the top layer of the skin's stratum granulosum, not just the second top layer as previously thought.
research Desmosomes in Developing Human Epidermis
Desmosomes are crucial for human skin development, increasing in density as the skin matures.
research Epidermal and hair follicle trans glutaminases and crosslinking in skin
research Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex
Mutant keratins cause inflammation in Epidermolysis Bullosa Simplex, suggesting targeting them could help treat the disorder.
research The expanding significance of keratin intermediate filaments in normal and diseased epithelia
Keratin proteins are increasingly recognized as important for cell health and are linked to many diseases.
research Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis
Trichohyalin is also found in the outer layers of normal human skin.
research In vitro Keratin Expression of Hair Cells
Hair cells grown in a lab showed specific hair proteins.