Keratinization and Its Disorders

    September 2012 in “ Oman Medical Journal ”
    Shibani Shetty, S. Gokul
    The document reviewed the structure and function of keratins, which are structural proteins crucial for maintaining the integrity of keratinocytes. It highlighted that humans have around 30 keratin families, divided into acidic and basic groups, with 54 functional genes coding for them. These keratins are expressed in specific patterns depending on epithelial type and differentiation stage. Mutations in keratin genes were linked to tissue fragility disorders affecting skin and mucosa. Keratins serve as differentiation markers, with antibodies to keratin aiding in diagnostic pathology. The review also focused on keratinization disorders, particularly in the oral cavity, and noted the clinical significance of keratin.
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