research Small molecules and small molecule drugs in regenerative medicine
Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.
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research Function of KLF4 in Stem Cell Biology
KLF4 is important for maintaining stem cells and has potential in cancer treatment and wound healing.
research MicroRNA profiles of four induced pluripotent stem cell lines derived from distinct tissues
iPSC lines from different tissues share a common miRNA profile, supporting their pluripotent nature.
research The remarkable legacy of the K6/ODC mouse: mechanisms of polyamine-promoted tumorigenesis revealed
Polyamines are crucial for skin tumor development, and inhibiting them can prevent tumors.
research EMT Factors and Metabolic Pathways in Cancer
EMT and metabolic pathways help cancer cells resist treatment and spread.
research Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development
Mitochondrial reactive oxygen species are essential for skin and hair development.
research Life Sciences Discovery and Technology Highlights
New technologies show promise in healing wounds, treating cancer, autoimmune diseases, and genetic disorders.
research Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis.
Corneal cells can transform into hair-producing skin cells when exposed to certain signals.
research Incorporation of hair follicles in 3D bioprinted models of human skin
3D bioprinting can now create skin with hair-like structures for medical use.
research Author response: Generation of inner ear hair cells by direct lineage conversion of primary somatic cells
Four transcription factors can convert mouse cells into hair cell-like cells, aiding hearing loss research and treatment.
research A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus
Oral mucosa heals with minimal scarring, offering insights for scarless wound healing.
research The Molecular Revolution in Cutaneous Biology: Noncoding RNAs: New Molecular Players in Dermatology and Cutaneous Biology
Non-coding RNAs are crucial for skin development and health.
research Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations
Bioactive glasses help heal skin wounds by promoting tissue repair and preventing infections.
research Skin-inspired phototherapeutic cryogel ameliorates infected wound healing by orchestrating mechanotransduction and immunomodulation
The cryogel effectively heals infected wounds and promotes tissue regeneration without scarring.
research Oxidative Stress and Skin Diseases: The Role of Lipid Peroxidation
Lipid peroxidation worsens skin diseases but may help treat cancer.
research Hidradenitis Suppurativa Tunnels: Unveiling a Unique Disease Entity
Hidradenitis suppurativa tunnels worsen the disease and often need surgery because current treatments are not very effective.
research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.
research Deciphering the Mesodermal Potency of Porcine Skin-Derived Progenitors (SKP) by Microarray Analysis
Pig skin cells can turn into mesodermal cells but lose their ability to become neural cells.
research 973 Dipeptidyl-peptidase 4 (DPP4)-positive fibroblasts are responsible for secretion of pro-fibrotic matrix proteins in the human skin
DPP4-positive fibroblasts play a major role in producing proteins that lead to skin fibrosis.
research 976 Knockout of mTOR/Akt inhibitor REDD1 results in hair cycle-independent dermal adipose expansion by promoting adipocyte differentiation
Removing REDD1 in mice increases skin fat by making fat cells larger and more numerous.
research 977 The wound healing of fractional photothermolysis mimicks scarless healing with minimal myofibroblast activation
Fractional photothermolysis helps wounds heal with minimal scarring.
research 975 Antifibrogenic activities of novel vitamin D3 analogs are dependent on VDR expression in human fibroblasts
New vitamin D3 forms need the vitamin D receptor to reduce fibrosis in human cells.
research Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche
Different types of stem cells and their environments are key to skin repair and maintenance.
research Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors
Fibroblasts can be turned into melanocytes for potential skin treatments.
research 606 Connecting signaling dynamics with cell fates in live mice
Stem cells control their future role by changing ERK signal timing, affecting tissue regeneration and cancer.
research 607 Cutaneous overexpression of cyclooxygenase-2 models androgenetic alopecia in adult mice
Cyclooxygenase-2 overexpression in mice skin causes hair loss like human androgenetic alopecia.
research Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells
Scientists created stem cells that can grow hair and skin.
research Stem cells in tissues, organoids, and cancers
Stem cells are crucial for tissue growth, cancer treatment, and disease modeling, but challenges remain in clinical use.
research Beyond Expectations
Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
research The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells
Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.