November 2015 in “European Journal of Inflammation” Cicatricial alopecia, a permanent hair loss condition, is mainly caused by damage to specific hair follicle stem cells and abnormal immune responses, with gene regulator PPAR-y and lipid metabolism disorders playing significant roles.
July 2003 in “Journal of Cutaneous Medicine and Surgery” Various skin conditions can be treated effectively with different methods, such as discontinuing certain drugs, using specific vaccines, applying creams, and changing lifestyle habits like smoking and drinking.
10 citations
,
September 2018 in “Regenerative Medicine” New hair can grow from large wounds in mice, but less so as they age, involving reprogramming of skin cells and specific molecular pathways.
35 citations
,
January 2006 in “Cancer Research” Mice with extra PKCδ resist chemical-induced skin cancer but not UV-induced.
18 citations
,
April 2013 in “Inflammatory Bowel Diseases” People with Inflammatory Bowel Disease often lose hair due to stress, medication side effects, or lack of nutrients, and treatment depends on the specific cause.
12 citations
,
January 2013 in “Acta Histochemica” Junctional proteins stabilize the inner root sheath and connect the companion layer in human hair.
July 2018 in “Elsevier eBooks” Up to half of people experience itchy scalp, often due to skin conditions like seborrheic dermatitis or psoriasis, and treatments vary based on the specific cause.
July 2003 in “Journal of Cutaneous Medicine and Surgery” Certain drugs can cause skin lupus, but stopping the drug usually helps. Vaccines work against smallpox, genital herpes, and a type of human papillomavirus. More frequent light therapy clears psoriasis faster. Certain treatments work for psoriasis and dermatitis. A specific cream effectively treats a type of skin cancer. Low iron levels aren't directly linked to chronic hair loss.
101 citations
,
June 2003 in “The EMBO Journal” Phospholipase Cδ1 is crucial for normal skin and hair development.
5 citations
,
February 2025 in “Frontiers in Immunology” Lactate is vital for skin health, influencing metabolism, the skin barrier, immune responses, and has therapeutic potential for skin disorders.
16 citations
,
February 2013 in “Molecular Medicine Reports” CD34+ cells from fat tissue help form hair follicles and blood vessels in skin.
2 citations
,
August 2024 in “JID Innovations” AD-derived keratinocytes effectively mimic inflammation in atopic dermatitis.
36 citations
,
April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.
152 citations
,
December 2003 in “Micron” As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.
4 citations
,
January 2019 in “Micron” Fetal hair follicles have melanocytes with melanosomes at different stages, which are broken down into pigment particles in keratinocytes.
48 citations
,
March 2010 in “PloS one” C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.
36 citations
,
October 2007 in “Journal of Investigative Dermatology” Betacellulin helps blood vessel growth in wounds but delays hair growth.
25 citations
,
January 2015 in “World journal of stem cells” Hair follicle stem cells can become different cell types and may help treat neurodegenerative disorders.
17 citations
,
May 2018 in “BMC genomics” Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.
14 citations
,
December 2018 in “The American journal of pathology” Activating Nrf2 in skin cells speeds up wound healing by increasing the growth of certain stem cells.
1 citations
,
May 2021 in “Cell Host & Microbe” Skin bacteria, specifically Streptococcus and Staphylococcus, help in hair regrowth after skin injury and speed up wound healing.
13 citations
,
September 2021 in “Current Issues in Molecular Biology” Dexpanthenol helps human hair follicle cells grow by preventing aging and death, and by supporting growth signals.
12 citations
,
July 2015 in “Experimental Dermatology” Gasdermin A3 overexpression in skin causes inflammation and hair loss.
December 2024 in “Frontiers in Genetics” EGFR and mTOR inhibitors may help manage Olmsted syndrome symptoms.
13 citations
,
August 1999 in “Journal of Investigative Dermatology” Bikunin is found on the cell boundaries of certain skin layers and may help regulate skin and hair functions.
5 citations
,
February 2022 in “Stem cell reports” Thymic stromal lymphopoietin (TSLP) promotes hair growth, especially after skin injury.
February 2025 in “Applied Sciences” Scenedesmus deserticola JD052 extracts may help hair growth and could be a natural treatment for hair loss.
February 2024 in “Veterinary sciences” Canine pemphigus foliaceus involves significant immune activity and shares similarities with human pemphigus.
December 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” MCPIP1 in myeloid cells is important for skin cancer development and healthy hair growth.
January 2022 in “Faculty of 1000 Research Ltd” Understanding molecular mediators can improve skin healing treatments.