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research The Autoimmune Regulator (AIRE), Which Is Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17

24 citations , February 2011 in “The American journal of pathology”

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.

research EGFR: stopping stathmin to start the cycle

March 2016 in “Experimental Dermatology”

EGFR helps hair follicles transition properly by controlling Stathmin levels.

research Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes

52 citations , October 1995 in “Experimental Cell Research”

Human hair keratin genes hHa2 and hHb1 are located on chromosomes 17 and 12.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research Heterozygous KRT32 variant is responsible for autosomal dominant loose anagen hair syndrome

May 2025

A KRT32 gene variant causes loose anagen hair syndrome.

research The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle

165 citations , September 2001 in “Genes & development”

CDP is crucial for lung and hair follicle cell development.

research Coordinating Stem Cell Behavior in the Hair Follicle

September 2025 in “Digital Commons - RU (Rockefeller University)”

Nfib in hair follicle stem cells boosts melanocyte stem cell growth and differentiation.

research IKZF1 and Ikaros Overexpression Results in Alopecia Areata‐Like Phenotype in Mice

March 2025 in “Experimental Dermatology”

Overexpression of IKZF1 and Ikaros causes hair loss in mice similar to alopecia areata.

research Expression ofSfrp2Is Increased in Catagen of Hair Follicles and Inhibits Keratinocyte Proliferation

25 citations , January 2014 in “Annals of Dermatology”

Sfrp2 increases during hair follicle catagen phase and slows keratinocyte growth.

Differential Expression of Keratin and Keratin-Associated Proteins Linked with Hair Loss in Spontaneously Mutated Inbred Mice

research Differential expression of keratin and keratin associated proteins are linked with hair loss condition in spontaneously mutated inbred mice

July 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Hair loss in certain mice is linked to changes in keratin-related genes.

research The epidermal growth factor receptor decreases Stathmin 1 and triggers catagen entry in the mouse

10 citations , December 2015 in “Experimental dermatology”

EGFR helps mouse hair follicles stop growing by reducing certain growth regulators.

CRISPR/Cas9-Mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

research CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

13 citations , March 2020 in “Genes”

Disrupting the FGF5 gene in rabbits leads to longer hair by extending the hair growth phase.

research Tfap2b specifies an embryonic melanocyte stem cell that retains adult multi-fate potential

June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.

research Role of human type II hair keratins in intermediate filament bundling in vitro

October 2015

research 321 Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia

1 citations , October 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Removing HIF-P4H-2 from certain skin cells in mice causes hair loss on the body but not the head.

research Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models

5 citations , August 2019 in “iScience”

Deleting the Trf1 protein in mice is safe and may help prevent cancer without major side effects.

research Identification of the Novel Membrane-Associated Protein AgK114 on Hamster Keratinocytes Recognized by a Monoclonal Antibody K114

4 citations , January 2004 in “Biological and Pharmaceutical Bulletin”

AgK114 protein helps in hamster skin injury recovery.

research Localization and Regulation of Expression of the FAR-17A Gene in the Hamster Flank Organs

16 citations , July 1996 in “Journal of Investigative Dermatology”

research Effect of overexpression of KLF4 on the growth and development of hair follicles in mice

2 citations , August 2023 in “Development Genes and Evolution”

research Structure and hair follicle-specific expression of genes encoding the rat high sulfur protein B2 family

12 citations , February 1998 in “Gene”

The B2 genes are crucial for hair growth in rats.

research Expression of a truncated form of hHb1 hair keratin in human breast carcinomas

14 citations , December 1998 in “British Journal of Cancer”

Truncated hHb1 keratin may play a role in breast cancer cell transformation.

research Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression

14 citations , April 2016 in “PloS one”

The KRTAP11-1 gene promoter is crucial for specific expression in sheep wool cortex.

research ATP-dependent chromatin remodeling during mammalian development

182 citations , August 2016 in “Development”

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

research Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice

16 citations , October 2014 in “Cell death and disease”

FoxN1 overexpression in young mice harms immune cell and skin development.

research Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling

35 citations , June 2012 in “PloS one”

Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.

research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

53 citations , September 1999 in “The journal of cell biology/The Journal of cell biology”

K16 can partially replace K14 but causes hair loss and skin issues.

research Transcription Regulation and Protein Subcellular Localization of the Truncated Basic Hair Keratin hHb1-ΔN in Human Breast Cancer Cells

8 citations , June 2001 in “Journal of Biological Chemistry”

A truncated protein linked to breast cancer may change cell adhesion.

research Keratin expression by corneal and limbal stem cells during development

25 citations , August 2020 in “Experimental eye research/Experimental Eye Research”

Different types of cells in the eye express specific keratins at various stages of development.

research The Human Type II Keratin Gene Cluster on Chromosome 12q13.13: Final Count or Hidden Secrets?

9 citations , February 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

The document concludes that the human keratin gene cluster is complex, with a need for updated naming to reflect over 50 functional genes important for hair and skin biology.

research Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

324 citations , May 2002 in “Oncogene”

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