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research 880 Triptolide (TRP), a diterpenoid, shows a strong efficacy and a safe profile in the topical treatment of actinic keratosis lesions in a UV-B-induced mouse model

April 2017 in “Journal of Investigative Dermatology”

Triptolide effectively and safely reduces actinic keratosis lesions in mice.

research Hair-Specific Keratins: Characterization and Expression of a Mouse Type I Keratin Gene

27 citations , November 1991 in “Journal of Investigative Dermatology”

research Characterization and expression analysis of the hair keratin associated protein KAP26.1

50 citations , July 2008 in “British Journal of Dermatology”

research Location and phenotype of human adult keratinocyte stem cells of the skin

233 citations , October 2004 in “Differentiation”

Stem cells are in deep skin layers, while differentiating cells are in shallow layers.

research Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid‐treated culture of a newborn rat keratinocyte cell line

39 citations , August 1998 in “FEBS Letters”

Two new enzymes, PAD-R11 and PAD-R4, were cloned and showed activity, with PAD-R11 resembling epidermal enzymes.

research Kartagener Syndrome With Ectodermal Anomalies in An Adolescent Female: A Case Report

February 2026 in “Journal of Chittagong Medical College Teachers Association”

A 17-year-old girl with Kartagener's syndrome also has unusual skin, hair, and nail issues.

research Stem and cancer cells Wnt long telomeres

August 2012 in “Nature Cell Biology”

A pathway helps maintain long telomeres in both stem and cancer cells.

research 167 Epidermal GRK2 knockout triggers a hair loss phenotype with features resembling immune-mediated alopecias

November 2023 in “Journal of Investigative Dermatology”

Removing GRK2 in skin cells causes hair loss similar to immune-related alopecia.

research Pediatric Clinical Trial Program in Progress: A Phase 3 Study and Long-term Extension Study to Evaluate the Efficacy and Safety of Ritlecitinib in Children 6 to <12 years of Age With Severe Alopecia Areata

March 2026 in “SKIN The Journal of Cutaneous Medicine”

Ritlecitinib is being tested for safety and effectiveness in young children with severe alopecia areata.

A New Heterozygous Variant of c.1225_1227delTTC (p.Phe409del) in Insulin Receptor Gene Associated with Severe Insulin Resistance and Hyperandrogenemia in an Adolescent Female with Type A Severe Insulin Resistance Syndrome

research A New Heterozygous Variant of c.1225_1227delTTC (p.Phe409del) in Insulin Receptor Gene Associated with Severe Insulin Resistance and Hyperandrogenemia in an Adolescent Female with Type A Severe Insulin Resistance Syndrome

1 citations , November 2024 in “Diabetes Metabolic Syndrome and Obesity”

A specific gene variant is linked to severe insulin resistance and hormone imbalance in a teenage girl.

research Loss‐of‐function of Endothelin receptor type A results in Oro‐Oto‐Cardiac syndrome

11 citations , March 2020 in “American Journal of Medical Genetics Part A”

A mutation in the EDNRA gene causes Oro-Oto-Cardiac syndrome, affecting face and heart development.

research Structure and site of expression of a murine type II hair keratin

18 citations , February 1992 in “Molecular Biology Reports”

A specific type II hair keratin was identified and found in hair cortex and tongue cells.

research Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency

42 citations , September 2003 in “Journal of Investigative Dermatology”

A missing mK6irs1 gene causes hair loss in mice.

research Identification of compound heterozygous mutations in AP1B1 leading to the newly described recessive keratitis–ichthyosis–deafness (KIDAR) syndrome

11 citations , January 2021 in “British Journal of Dermatology”

Mutations in the AP1B1 gene cause a new syndrome with skin, hearing, and developmental issues.

Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

research Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

40 citations , December 2012 in “PLoS ONE”

Removing Ctip2 in skin cells causes skin inflammation similar to atopic dermatitis.

research Ku80 as a Novel Receptor for Thymosin β4 That Mediates Its Intracellular Activity Different from G-actin Sequestering

37 citations , November 2007 in “Journal of Biological Chemistry”

Ku80 is a key receptor for Thymosin β4, affecting cell migration and wound healing.

research Keratins in health and cancer: more than mere epithelial cell markers

438 citations , October 2010 in “Oncogene”

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

HPV8 E6 Induced STAT3 Activation Leads to Hair Follicle Junctional Zone Keratinocyte Stem Cell Proliferation and Expansion in Actinic Keratoses

research 277 HPV8 E6 induced STAT3 activation leads to hair follicle junctional zone keratinocyte stem cell proliferation and expansion in actinic keratoses

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

HPV8 causes hair follicle stem cells to grow, leading to skin lesions.

research Human Hair Keratin‐Associated Proteins (KAPs)

226 citations , January 2006 in “International review of cytology”

Keratin-associated proteins are crucial for hair strength and structure.

A Study of the Expression of Small Conductance Calcium-Activated Potassium Channels (SK1-3) in Sensory Endings of Muscle Spindles and Lanceolate Endings of Hair Follicles in the Rat

research A Study of the Expression of Small Conductance Calcium-Activated Potassium Channels (SK1-3) in Sensory Endings of Muscle Spindles and Lanceolate Endings of Hair Follicles in the Rat

17 citations , September 2014 in “PLoS ONE”

SK2 channels help control sensory signals in rat muscle spindles and hair follicles.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

research Role of BK channels and Kv4.2 channels in the electrophysiological properties of Merkel cells in rat whisker hair follicles

October 2025 in “Journal of Neurophysiology”

BK and Kv4.2 channels help Merkel cells in rat whiskers sense touch.

research The Two Functional Keratin 6 Genes of Mouse Are Differentially Regulated and Evolved Independently from Their Human Orthologs

79 citations , October 1998 in “Genomics”

Mouse keratin 6 genes evolved independently from human ones and are regulated differently.

research The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle

165 citations , September 2001 in “Genes & development”

CDP is crucial for lung and hair follicle cell development.

research A comparative study of materials assembled from recombinant K31 and K81 and extracted human hair keratins

2 citations , September 2020 in “Biomedical materials”

Recombinant keratin materials may better promote skin cell differentiation than natural keratin.

research Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes

37 citations , January 2010 in “Human Molecular Genetics”

FTase and GGTase-I are essential for skin keratinocyte health.

research Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer

December 2024 in “European journal of medical research”

research KY19382 Accelerates Cutaneous Wound Healing via Activation of the Wnt/β-Catenin Signaling Pathway

18 citations , July 2023 in “International Journal of Molecular Sciences”

KY19382 speeds up wound healing by activating a specific cell signaling pathway.

research The innervation of the mystacial pad in the adult rat studied by anterograde transport of HRP conjugates

47 citations , May 1994 in “Experimental Brain Research”

The mystacial pad's innervation in adult rats is more complex than previously thought.

research A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population

21 citations , March 2015 in “Neurological Sciences”

A new genetic mutation linked to CARASIL syndrome and small artery disease was found in a Chinese family.

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