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research Comprehensive RNA sequencing in primary murine keratinocytes and fibroblasts identifies novel biomarkers and provides potential therapeutic targets for skin-related diseases

17 citations , October 2021 in “Cellular & Molecular Biology Letters”

This study utilized RNA sequencing to analyze gene expression in primary murine keratinocytes and fibroblasts, identifying 4,309 differentially expressed genes (DEGs) between the two cell types, with 2,197 genes highly expressed in fibroblasts and 2,112 in keratinocytes. The research highlighted specific genes such as collagen, transcription factors, and growth factors, which play roles in skin elasticity, wound healing, cell differentiation, and immune response regulation. Novel biomarkers like Plac8 and Agtr2 for fibroblasts, and Ly6a and Col18a1 for keratinocytes, were identified, offering potential therapeutic targets for skin-related diseases such as burns, wounds, and aging. The study involved eight newborn male mice and provided a valuable resource for further research on treating skin disorders.

research Dissection of a Complex Enhancer Element: Maintenance of Keratinocyte Specificity but Loss of Differentiation Specificity

42 citations , June 2002 in “Molecular and Cellular Biology”

Keratinocyte gene expression is controlled by multiple modules with specific binding sites.

research Multimodal therapeutic approach for a severe case of kaposiform lymphangiomatosis from procedural interventions to targeted therapies

1 citations , May 2024 in “Pediatric Blood & Cancer”

Trametinib can effectively treat severe kaposiform lymphangiomatosis when other treatments fail.

research RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling

21 citations , February 2017 in “PLoS ONE”

RhoA helps skin stem cells grow, aiding wound healing.

research A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy

188 citations , June 1998 in “Molecular cell”

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

research Twist1 is required for the development of UVB‐induced squamous cell carcinoma

11 citations , March 2021 in “Molecular Carcinogenesis”

Twist1 is crucial for UVB-induced skin cancer development.

research PKC downregulation upon rapamycin treatment attenuates mitochondrial disease

26 citations , December 2020 in “Nature metabolism”

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

research ELL Facilitates RNA Polymerase II–Mediated Transcription of Human Epidermal Proliferation Genes

4 citations , May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

ELL is crucial for gene transcription related to skin cell growth.

research A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity

98 citations , December 2015 in “The Journal of Cell Biology”

Keratin is crucial for skin barrier formation and affects mitochondrial function.

research Expression patterns of TRα and CRABPII genes in Chinese cashmere goat skin during prenatal development

August 2015 in “Han'gug dongmul jawon gwahag hoeji/Han-guk dongmul jawon gwahak hoeji/Journal of animal science and technology”

TRα and CRABPII genes change their activity levels during goat fetal skin development.

research Autosomal-Dominant Woolly Hair Resulting from Disruption of Keratin 74 (KRT74), a Potential Determinant of Human Hair Texture

97 citations , March 2010 in “The American Journal of Human Genetics”

A mutation in the KRT74 gene causes tightly curled hair.

research Transcriptional regulation analysis and the potential transcription regulator site in the extended KAP6.1 promoter in sheep

5 citations , July 2014 in “Molecular Biology Reports”

research Differential Expression of Genes Encoding a Cysteine-Rich Keratin Family in the Hair Cuticle

35 citations , September 1994 in “Journal of Investigative Dermatology”

research Variation in the caprine keratin-associated protein 15-1 (KAP15-1) gene affects cashmere fibre diameter

30 citations , March 2019 in “Archives animal breeding/Archiv für Tierzucht”

The KRTAP15-1 gene affects cashmere fiber thickness in goats.

RPGRIP1L Facilitates Desmosomal Adhesion Through Suppressing PKCβII-Mediated Desmoglein Endocytosis: Implication in Pemphigus

research 441 RPGRIP1L facilitates desmosomal adhesion through suppressing PKCβII-mediated desmoglein endocytosis: Implication in pemphigus

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

RPGRIP1L helps skin cells stick together by blocking PKCβII, which can prevent skin blistering like in pemphigus.

research Keratin 17 Gene Expression during the Murine Hair Cycle

70 citations , March 1997 in “Journal of Investigative Dermatology”

research A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue

31 citations , April 2004 in “Journal of Investigative Dermatology”

A new mouse gene, Keratin 17n, is mainly found in nail tissue and may explain why mice without Keratin 17 don't have nail issues.

research Delayed-onset pachyonychia congenita caused by a novel mutation in the V2 domain of keratin 6b

4 citations , December 2013 in “The Journal of Dermatology”

A new mutation in the K6b gene caused a girl's late-appearing nail condition.

HPV8 E6 Induced STAT3 Activation Leads to Hair Follicle Junctional Zone Keratinocyte Stem Cell Proliferation and Expansion in Actinic Keratoses

research 277 HPV8 E6 induced STAT3 activation leads to hair follicle junctional zone keratinocyte stem cell proliferation and expansion in actinic keratoses

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

HPV8 causes hair follicle stem cells to grow, leading to skin lesions.

research Expression, characterization, and structural analysis of human liver delta4-3-ketosteroid 5beta-reductase (AKR1D1) and its disease-related mutant P133R

January 2009 in “ScholarlyCommons (University of Pennsylvania)”

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

research A Unique Expression of Keratin 14 in a Subset of Trophoblast Cells

14 citations , October 2015 in “PLoS ONE”

Keratin 14 is uniquely found in a specific group of placental cells.

research Overexpression of human keratin 16 produces a distinct skin phenotype in transgenic mouse skin

25 citations , September 1995 in “Biochemistry and Cell Biology”

High levels of human keratin 16 in mice cause skin lesions and abnormal skin development.

research Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

64 citations , February 2008 in “Cancer Research”

Inactivating both p53 and Rb genes in mice speeds up aggressive skin cancer development.

research Role of Annexin A2 isoform 2 on the aggregative growth of dermal papillae cells

1 citations , October 2018 in “Bioscience reports”

Annexin A2 isoform 2 helps dermal papillae cells grow, affecting hair growth.

research Role of BK channels and Kv4.2 channels in the electrophysiological properties of Merkel cells in rat whisker hair follicles

October 2025 in “Journal of Neurophysiology”

BK and Kv4.2 channels help Merkel cells in rat whiskers sense touch.

research Deleting keratins to find one

August 2001 in “The Journal of Cell Biology”

A new keratin gene was found in mice, explaining hair growth.

research AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

17 citations , February 2019 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

research The Auxin-Regulated CrRLK1L Kinase ERULUS Controls Cell Wall Composition during Root Hair Tip Growth

109 citations , February 2018 in “CB/Current biology”

ERULUS controls root hair growth by regulating cell wall composition and pectin activity.

research Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes

27 citations , February 2003 in “European Journal Of Oral Sciences”

SVpgC2a cells show abnormal growth and keratin changes, modeling early cancer development.

research Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration

8 citations , August 2023 in “Journal of Investigative Dermatology”

Corin speeds up wound healing by helping skin cells move and grow.

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