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Short-Term Rho-Associated Kinase Inhibitor Treatment Accelerates Primary Keratinocyte Growth Without Affecting the Stem Cell Population

research 557 Short-term Rho-associated kinase inhibitor treatment accelerates primary keratinocyte growth without affecting the characteristics of the stem cell population

November 2022 in “Journal of Investigative Dermatology”

Short-term treatment with ROCKi increases skin cell growth without changing stem cell features.

research Histopathological Analysis on keratin2-6 g Expression in Hair Mutant Mouse Hague

January 2002 in “Proceedings of The Japanese Society of Animal Models for Human Diseases”

Keratin2-6g is crucial for hair follicle development, with mutations causing cell degeneration and vacuolation.

research First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

505 citations , October 2011 in “Journal of clinical oncology”

MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.

research Unilateral keratosis pilaris atrophicans faciei mimicking follicular mucinosis

3 citations , April 2011 in “Journal of the American Academy of Dermatology”

A 19-year-old man had a rare skin condition on one side of his face that looked like another skin disease.

research Trichorhinophalangeal Syndrome

10 citations , January 1995 in “Dermatology”

Dermatologists should consider congenital syndromes like TRPS in young adults with early hair loss.

research Cornification in reptilian epidermis occurs through the deposition of keratin‐associated beta‐proteins (beta‐keratins) onto a scaffold of intermediate filament keratins

33 citations , October 2012 in “Journal of Morphology”

Reptile skin hardens by layering beta-proteins on keratin.

research Transcriptome-based selection and validation of optimal house-keeping genes for skin research in goats (Capra hircus)

23 citations , July 2020 in “BMC Genomics”

NCBP3, SDHA, and PTPRA are the best genes for accurate goat skin research.

research Tralokinumab as a therapeutic option for patients with concurrent atopic dermatitis and alopecia areata

9 citations , January 2024 in “International Journal of Dermatology”

research Spiny keratoderma ‐ a demonstration of hair keratin and hair type keratinization

30 citations , January 1999 in “Journal of Cutaneous Pathology”

Spiny keratoderma may be ectopic hair formation on palms and soles.

research Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid‐treated culture of a newborn rat keratinocyte cell line

39 citations , August 1998 in “FEBS Letters”

Two new enzymes, PAD-R11 and PAD-R4, were cloned and showed activity, with PAD-R11 resembling epidermal enzymes.

research AUTOSOMAL DOMINANT INHERITANCE OF ALOPECIA CONGENITA WITH KERATOSIS PALMO-PLANTARIS

April 1977 in “Pediatric Research”

research 23 Studies of the Biochemical Basis of Kinky Hair Disease

1 citations , May 1967 in “Pediatric Research”

research Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia

28 citations , June 2012 in “International Journal of Molecular Medicine”

Radiation damages hair stem cells and changes keratin expression, with Krt5 as a potential marker for radiation effects.

research Acne Keloidalis Nuchae

40 citations , May 2010 in “American Journal of Clinical Dermatology”

AKN might be a skin marker for metabolic syndrome.

research Transcriptome-based Selection and Validation of Optimal House-keeping Genes for Skin Research in Goats (Capra hircus)

July 2020

NCBP3, SDHA, and PTPRA are the best genes for normalizing goat skin experiments.

Unraveling the Link Between Insulin Resistance and Androgen Excess

research Unravelling the link between insulin resistance and androgen excess

December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)”

AKR1C3 could be a treatment target for metabolic issues in PCOS.

research Acne Keloidalis Nuchae Successfully Treated with Halobetasol 0.01% and Tazarotene 0.045% Lotion

July 2022 in “SKIN The Journal of Cutaneous Medicine”

A new lotion with halobetasol and tazarotene successfully treats acne keloidalis nuchae.

research CRISPR/Cas9-mediated Generation ofCOL7A1-deficient Keratinocyte Model of Recessive Dystrophic Epidermolysis Bullosa

June 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Scientists created cell lines to study a genetic skin disorder using CRISPR technology.

research The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1

119 citations , September 2000 in “Journal of Biological Chemistry”

GKLF/KLF4 and Sp1 control Keratin 19 gene activity, influencing cancer-related changes.

research Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis

1 citations , October 2017 in “Frontiers in Physiology”

Hair follicle keratin may have been used in tooth enamel evolution.

research The in vitro Assembly of Hair Follicle Keratins: Comparison of Cortex and Companion Layer Keratins

13 citations , January 2002 in “Biological chemistry”

Different conditions affect how hair proteins assemble, and certain mutations can change their structure.

Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Safety and Clinical Efficacy of Kūlaris, an Herbal Supplement for Mild to Severe Acne Vulgaris: A 12-Week Randomized, Double-Blind, Placebo-Controlled Study

research Safety and Clinical Efficacy of KūlarisTM, an Herbal Supplement for Mild to Severe Acne Vulgaris – A 12-Week Randomized, Double Blind, Placebo-Controlled Study

September 2025 in “Clinical Cosmetic and Investigational Dermatology”

Kūlaris improved quality of life for acne sufferers without side effects.

research SnapshotDx Quiz: January 2021

December 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Papulopustular rosacea is an inflammatory skin condition treatable with lifestyle changes and medications.

research Acquired Progressive Kinking of the Hair: A Narrative Review of the Androgen‐Dependent Phenotype

January 2026 in “International Journal of Dermatology”

APKH in young males may signal early hair loss and needs early attention.

Oncogenic Ras Mutation Induces Spatiotemporally Specific Tissue Deformation Through Converting Fluctuated Into Sustained ERK Activation

research LB1011 Oncogenic ras mutation induces spatiotemporally specific tissue deformation through converting fluctuated into sustained ERK activation

July 2022 in “Journal of Investigative Dermatology”

A specific mutation in Kras causes abnormal tissue changes by making a cell signal continuously active, which disrupts normal cell coordination.

research Non-Albicans Yeast Scalp Infection in a 6-Year-Old Boy: A Case Report of Candida Parapsilosis and Antifungal Susceptibility Testing

July 2023 in “Zenodo (CERN European Organization for Nuclear Research)”

Ketoconazole effectively treated a scalp infection in a 6-year-old boy, leading to full recovery.