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GlossaryLabel-Retaining Cells

cells that divide infrequently and retain DNA labels

Label-Retaining Cells (LRCs) are a type of cell that retains a DNA label over an extended period, indicating they divide infrequently. This characteristic is often used to identify stem cells or progenitor cells in tissues, including hair follicles, as these cells typically divide less frequently than other cell types, allowing them to maintain tissue homeostasis and regeneration.

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research Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

421 citations , September 2003 in “Development”

Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.

Label Retaining Cells with Myoepithelial Characteristics from the Proximal Acinar Region Define Stem Cells in the Sweat Gland

research Label Retaining Cells (LRCs) with Myoepithelial Characteristic from the Proximal Acinar Region Define Stem Cells in the Sweat Gland

36 citations , September 2013 in “PLoS ONE”

Sweat gland stem cells help maintain glands, aid wound healing, and can regenerate skin structures.

research The Localization of Label-Retaining Cells in Eccrine Glands

28 citations , January 2009 in “Journal of Investigative Dermatology”

Stem cells in eccrine glands could be used for regenerative medicine.

research The Localization of Label-Retaining Cells in Mouse Nails

22 citations , October 2007 in “Journal of Investigative Dermatology”

Stem cells in mouse nails are found in the nail matrix and may control nail growth.

Defining the Localization and Molecular Characteristics of Minor Salivary Gland Label-Retaining Cells

research Defining the Localization and Molecular Characteristic of Minor Salivary Gland Label-Retaining Cells

18 citations , April 2014 in “Stem cells”

The study found stem cells in minor salivary glands that can differentiate and are involved in tumor formation when exposed to tobacco.

Targeted Elimination of Follicular Label-Retaining Cells by Photo-Induced Cell Killing Caused a Defect in Follicular Renewal in Mice

research Targeted elimination of the follicular label-retaining cells by photo-induced cell killing caused a defect on follicular renewal on mice

8 citations , September 2002 in “Genes to Cells”

Killing specific cells in hair follicles can lead to hair growth problems in mice.

research Epithelial Stem Cells: Turning over New Leaves

508 citations , February 2007 in “Cell”

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

387 citations , November 2003 in “Journal of Investigative Dermatology”

The K15 promoter effectively targets stem cells in the hair follicle bulge.

research Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell?

153 citations , October 2007 in “Cell Stem Cell”

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

research Epidermal Stem Cells do not Communicate Through Gap Junctions

73 citations , January 2002 in “Journal of Investigative Dermatology”

Epidermal stem cells don't use gap junctions to communicate.

Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

72 citations , July 2012 in “Journal of Investigative Dermatology”

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

research Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells

36 citations , April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.

research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but not for Maintenance of the Epidermal Stem Cell Compartment

25 citations , March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.

research The HPV16 oncogenes cause aberrant stem cell mobilization

23 citations , May 2013 in “Virology”

HPV16 oncogenes disrupt the normal activity of hair follicle stem cells.

research The Hair Follicle Bulge: A Niche for Adult Stem Cells

19 citations , July 2011 in “Microscopy and Microanalysis”

The hair follicle bulge is an important area for adult stem cells involved in hair growth and repair, with potential for medical use needing more research.

research Context-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancer

13 citations , September 2019 in “EBioMedicine”

sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

research Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice

October 2014 in “Cancer research”

Blocking mTORC1 reduces skin tumor growth in mice.

research Characterization of new stem/progenitor cells in skin appendages

July 2013 in “University of Southern California Digital Library”

New stem cells in nails and sweat glands can regenerate skin and hair.

research Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion

April 2012 in “Cancer research”

Blocking mTORC1 may help prevent skin cancer by stopping the growth of certain skin stem cells.

research Stem Cells and their Niches

1 citations , January 2013 in “Journal of Investigative Dermatology”

The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.

research Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt^WT mice

8 citations , September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

research Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia

7 citations , November 2014 in “Histochemistry and Cell Biology”

The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.

research Developmental Plasticity of Patterned and Regenerating Oral Organs

5 citations , January 2015 in “Current Topics in Developmental Biology”

Fish teeth and taste bud densities are linked and can change between types due to shared genetic and molecular factors.

research Molecular and Cellular Characterization of Avian Reticulate Scales Implies the Evo–Devo Novelty of Skin Appendages in Foot Sole

1 citations , July 2023 in “Journal of developmental biology”

Bird foot scales develop differently and can repair but not fully regenerate due to the lack of specialized stem cell areas.

research Paneth Cells in Intestinal Homeostasis and Tissue Injury

146 citations , June 2012 in “PLoS ONE”

Paneth cells help support stem cells and aid tissue regeneration after injury.

research Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage

441 citations , May 1996 in “Journal of Cell Science”

Keratin 19 helps identify skin stem cells, with its presence varying by body location, age, and culture stage.

research Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells

43 citations , December 2008 in “Molecular biology of the cell”

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.

research Lgr5 marks cycling, yet long-lived, hair follicle stem cells

835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Dissecting the bulge in hair regeneration

86 citations , February 2012 in “Journal of Clinical Investigation”

Stem cells in hair follicles are diverse and change throughout the hair cycle.

research Characterization of a new, inducible transgenic mouse model with GFP expression in melanocytes and their precursors

14 citations , October 2017 in “Gene Expression Patterns”

A new mouse model helps study melanocyte cells using GFP expression.