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GlossaryLentivirus

virus that integrates into host DNA, used in gene therapy

A lentivirus is a type of virus that belongs to the retrovirus family and is known for its ability to infect and integrate into the DNA of host cells. These viruses can cause long-term, chronic infections and are used in gene therapy due to their ability to deliver genetic material into cells. HIV (Human Immunodeficiency Virus) is a well-known example of a lentivirus.

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research Lentivirus‐mediated subcutaneous JAM‐A modification promotes skin wound healing in a mouse model by strengthening the secretory function and proliferation of fibroblasts

5 citations , April 2022 in “Cell Biology International”

JAM-A modification speeds up skin wound healing by boosting fibroblast growth.

research Lentivirus-Mediated Expression of VEGF165 in Rat Hair Follicle Stem Cells

April 2015 in “MOJ Cell Science & Report”

Rat hair follicle stem cells can be used to improve blood vessel growth in engineered skin.

research Effect of lentivirus-mediated miR-182 targeting FGF9 on hallux valgus

4 citations , January 2021 in “International Journal of Medical Sciences”

miR-182 may help treat hallux valgus by targeting FGF9.

research A matter of life and death: self‐renewal in stem cells

150 citations , December 2012 in “EMBO Reports”

Stem cell self-renewal is complex and needs more research for full understanding.

research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

Using special RNA to target a mutant gene fixed hair problems in mice.

research Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

6 citations , February 2013 in “Journal of Visualized Experiments”

The method quickly analyzes hair growth genes and shows that blocking Smo in skin cells stops hair growth.

research Transduction‐induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma‐like phenotype

5 citations , August 2021 in “Experimental dermatology”

Overexpressing Merkel cell virus proteins in human hair follicles can create clusters of cells that resemble Merkel cell cancer.

research Expression of lipid-protein gene PLP2 in Liaoning cashmere goat

3 citations , February 2019 in “Animal biotechnology”

The PLP2 gene affects cashmere fiber quality in goats and is linked to hair growth and loss.

research Th22 is the effector cell of thymosin β15-induced hair regeneration in mice

January 2024 in “Inflammation and regeneration”

Th22 cells are essential for Tβ15-induced hair growth in mice.

research [Effect study of Sonic hedgehog overexpressed hair follicle stem cells in hair follicle regeneration].

July 2023 in “PubMed”

Sonic hedgehog helps hair follicle stem cells grow and can effectively regenerate hair follicles.

research [Experimental study on vascular endothelial growth factor 165 gene-modified rat hair follicle stem cells mediated by lentiviral vector].

February 2014 in “PubMed”

Modified rat hair follicle stem cells can help create artificial hair follicles, blood vessels, and skin.

research Ectopic expression of FGF5s induces wool growth in Chinese merino sheep

7 citations , June 2017 in “Gene”

Overexpression of FGF5s makes Chinese Merino sheep grow longer and heavier wool.

research Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship

October 2025 in “Influenza and Other Respiratory Viruses”

Certain alkaloids could help create new coronavirus drugs.

research The long road traveled in hematopoietic stem cell gene therapy

1 citations , October 2022 in “Molecular therapy”

The FDA approved the first gene therapy for a blood disorder after overcoming early challenges and demonstrating patient benefits.

research Detection of lentiviral constructs for release testing of CAR- T cells using digital droplet PCR

1 citations , May 2019 in “Cytotherapy”

The new ddPCR method reliably detects unwanted viruses in CAR-T cell products, ensuring their safety for patients.

research LncRNA MTC enhances the proliferation of Liaoning cashmere goat skin fibroblasts by modulating GSTM1-ASK1 interaction

March 2024 in “Cytologia”

LncRNA MTC boosts growth of goat skin cells, improving cashmere quality.

research LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells

12 citations , August 2020 in “Frontiers in Genetics”

H19 boosts hair growth potential by activating Wnt signaling, possibly helping treat hair loss.

research The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability

28 citations , January 2013 in “Stem cells”

Certain human skin cells marked by CD44 and ALDH are rich in stem cells capable of long-term skin renewal.

research Keratinocytes maintain compartmentalization between dermal papilla and fibroblasts in 3D heterotypic tri‐cultures

16 citations , August 2019 in “Cell Proliferation”

Keratinocytes help keep hair follicle cells and skin cells separate in 3D cultures, which is important for hair growth research.

Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells In Vitro by Forming a Complex With Tcf4 and β-Catenin

research Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin

13 citations , August 2020 in “Frontiers in Cell and Developmental Biology”

Twist1 helps maintain important features of cells crucial for hair growth by working with Tcf4 and β-catenin.

Follistatin and Secreted Frizzled-Related Protein 1, OVOL1-Regulated Genes, Are Important for Hair Follicle Neogenesis

research Follistatin and secreted frizzled-related protein 1, OVO homolog-like 1-regulated genes, are important for hair follicle neogenesis

4 citations , April 2015 in “Experimental Dermatology”

Certain genes controlled by OVOL1 are crucial for creating new hair follicles.

research Selling stem cells in Australia: assessing the impact of new advertising standards on business practices

1 citations , May 2019 in “Cytotherapy”

New Australian advertising rules improved stem cell marketing practices but further regulation is needed for consumer safety.

Impeding Glial Scarring Hyperplasia and Activating Axon Neogenesis via Immunomodulatory Microneedle Patch for Spinal Cord Repair

research Impeding Glial Scarring Hyperplasia and Activating Axon Neogenesis via Immunomodulatory Microneedle Patch for Spinal Cord Repair

November 2025

A new microneedle patch helps repair spinal cord injuries by reducing scarring and promoting nerve growth.

research Autologous stem cell-based interventions in Australia: exploring patient experience in light of regulatory exceptionalism

May 2019 in “Cytotherapy”

Patients in Australia underwent costly, unproven stem cell treatments due to weak regulations and aggressive marketing.

research Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

248 citations , November 2011 in “The EMBO Journal”

Wnt1/βcatenin signaling is crucial for heart repair after injury.

Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

174 citations , November 2016 in “Cell stem cell”

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

research MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2

123 citations , November 2012 in “Stem cells”

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

research Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

117 citations , March 2017 in “Nature Communications”

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

research Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation

112 citations , May 2020 in “Nature Communications”

Adult fibroblasts help heart cells mature and improve heart function.

Comparison of Viral RNA–Host Protein Interactomes Across Pathogenic RNA Viruses Informs Rapid Antiviral Drug Discovery for SARS-CoV-2

research Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2

100 citations , November 2021 in “Cell Research”

Cepharanthine and Trifluoperazine are effective against SARS-CoV-2.