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GlossaryLeucine-rich repeat

structural motif in proteins involved in various biological processes

Leucine-rich repeats (LRRs) are short sequences of amino acids found in proteins, characterized by the presence of the amino acid leucine at regular intervals. These repeats form a structural motif that creates a horseshoe-shaped domain, which is often involved in protein-protein interactions, playing crucial roles in various biological processes such as cell signaling, immune response, and the development of hair follicles.

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research Extracellular matrix sensing by FERONIA and Leucine‐Rich Repeat Extensins controls vacuolar expansion during cellular elongation in Arabidopsis thaliana

172 citations , March 2019 in “The EMBO Journal”

FERONIA and LRX proteins help control cell growth in plants by regulating vacuole expansion.

research Building a hair: tip growth inArabidopsis thalianaroot hairs

141 citations , June 2002 in “Philosophical Transactions of the Royal Society B Biological Sciences”

The study revealed how specific genes and proteins control root hair growth in plants.

research Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

291 citations , April 2010 in “Gastroenterology”

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

research Distinct tooth regeneration systems deploy a conserved battery of genes

September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Different fish use the same genes to regrow teeth.

research Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network

58 citations , February 2013 in “Journal of Biological Chemistry”

LGR5 mainly stays inside cells, moving to the trans-Golgi network, and this process is important for its role in cell signaling.

research Comparative Analysis of Chloroplast Genomes in Sansevieria Reveals Phylogenetic Relationships and High Variability Molecular Markers

December 2025 in “Agriculture”

Sansevieria and Dracaena are evolutionarily linked, and a specific gene marker can distinguish closely related species.

Cell Wall-Associated Root Hair Specific 10, a Proline-Rich Receptor-Like Kinase, Is a Negative Modulator of Arabidopsis Root Hair Growth

research Cell wall-associated ROOT HAIR SPECIFIC 10, a proline-rich receptor-like kinase, is a negative modulator of Arabidopsis root hair growth

33 citations , February 2016 in “Journal of Experimental Botany”

ROOT HAIR SPECIFIC 10 (RHS10) reduces the length of root hairs in Arabidopsis plants.

research Longer TA repeat but not V89L polymorphisms in the SRD5A2 gene may confer acne risk in the Chinese population

3 citations , January 2018 in “Postępy Dermatologii i Alergologii”

Longer TA repeats in the SRD5A2 gene may increase acne risk in Chinese people.

research Generation of human-induced pluripotent stem cell-derived adherent 3-dimensional skin hair-follicle organoids

2 citations , September 2022 in “Organoid”

A new method was developed to efficiently grow skin hair follicles from stem cells, potentially aiding alopecia treatment.

research Skin Stem Cells: At the Frontier Between the Laboratory and Clinical Practice. Part 1: Epidermal Stem Cells

2 citations , November 2015 in “Actas Dermo-Sifiliográficas”

Epidermal stem cells show promise for future dermatology treatments due to ongoing advancements.

Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms Behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin with Marilex in Pattern Hair Loss and Telogen Effluvium

research Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium

10 citations , May 2020 in “Dermatology Research and Practice”

Proteoglycans are important for hair growth, and a specific treatment can help reduce hair loss.

research Assessing the contribution of millets to the UN sustainable development goals: A systematic review

January 2025 in “The Pharma Innovation”

Millets support sustainable development by improving nutrition, aiding climate resilience, and boosting economic viability, especially for Indian farmers.

research Nanotechnology-based techniques for hair follicle regeneration

October 2023 in “Biomaterials”

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

research Resequencing Analyses Revealed Genetic Diversity and Selection Signatures during Rabbit Breeding and Improvement

March 2024 in “Genes”

Genetic analysis of rabbits identified key genes for traits like coat color, body size, and fertility.

research PolyQ length co-evolution in neural proteins

6 citations , April 2021 in “NAR Genomics and Bioinformatics”

PolyQ repeats in neural proteins evolve together, affecting brain function and disease.

research ENZYMES

1 citations , November 2011 in “British journal of pharmacology”

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

research Alpinetin promotes hair regeneration via activating hair follicle stem cells

11 citations , May 2022 in “Chinese medicine”

Alpinetin helps grow hair by turning on hair stem cells and is safe for use.

Fibroblast Lineage Switching as the Developmental Origin of Scarring and Target for Regenerative Healing

research Fibroblast Lineage Switching as the Developmental Origin of Scarring and Target for Regenerating Healing

January 2026 in “Preprints.org”

Mimicking fetal wound environments may enable scarless healing in adults.

research De novo filament formation by human hair keratins K85 and K35 follows a filament development pattern distinct from cytokeratin filament networks

2 citations , February 2021 in “FEBS open bio”

Human hair keratins K85 and K35 create unique filament patterns important for early hair formation.

research Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing

5 citations , April 2022 in “Frontiers in Medicine”

Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.