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GlossaryLipopolysaccharide

molecule in Gram-negative bacteria triggering strong immune responses

Lipopolysaccharide (LPS), also known as endotoxin, is a large molecule found in the outer membrane of Gram-negative bacteria. It plays a crucial role in the structural integrity of the bacteria and can trigger strong immune responses in humans, often leading to inflammation and, in severe cases, septic shock.

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Early Plant Growth and Biochemical Responses Induced by Azospirillum Brasilense Sp245 Lipopolysaccharides in Wheat (Triticum Aestivum L.) Seedlings Are Attenuated by Procyanidin B2

research Early plant growth and biochemical responses induced by Azospirillum brasilense Sp245 lipopolysaccharides in wheat (Triticum aestivum L.) seedlings are attenuated by procyanidin B2

11 citations , March 2018 in “Protoplasma”

Lipopolysaccharides boost wheat seedling growth, but procyanidin B2 weakens this effect.

research Minoxidil Promotes Hair Growth in a Mouse Model of Telogen Effluvium Induced by Lipopolysaccharide

November 2025 in “The Journal of Dermatology”

Minoxidil helps hair regrow faster in stress-related hair loss.

research Dexpanthenol ameliorates lipopolysaccharide-induced cardiovascular toxicity by regulating the IL-6/HIF1α/VEGF pathway

10 citations , January 2024 in “Heliyon”

Dexpanthenol helps protect the heart from damage by reducing inflammation and stress.

research Celery ameliorating against neurobehavioral and neurochemical disorders of perinatal lipopolysaccharides exposure in mice offspring

7 citations , January 2020 in “Journal of King Saud University - Science”

Celery helps protect against developmental and brain issues in mice exposed to certain toxins.

research Over-expression of TSPO in the hippocampal CA1 area alleviates cognitive dysfunction caused by lipopolysaccharide in mice

18 citations , June 2016 in “Brain Research”

Increasing TSPO in the brain may help improve memory problems.

research Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study

87 citations , June 2010 in “Stem Cell Research & Therapy”

Stem cells can move to brain injury sites and be tracked, showing promise for treating brain diseases.

Analysis of Hidradenitis Suppurativa-Linked Mutations in Four Genes and the Effects of PSEN1-P242LfsX11 on Cytokine and Chemokine Expression in Macrophages

research Analysis of hidradenitis suppurativa–linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages

25 citations , December 2018 in “Human Molecular Genetics”

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

research Screening for Anti-inflammatory Activities in Extracts from Korean Herb Medicines

14 citations , March 2014 in “Journal of the Society of Cosmetic Scientists of Korea”

Some Korean herb extracts can reduce inflammation and are safe for skin use.

research Dihydrotestosterone, and Not Testosterone, Enhances the LPS-Induced Inflammatory Cytokine Gene Expression in Human Adipocytes

7 citations , April 2023 in “Biomedicines”

Dihydrotestosterone boosts inflammation in fat cells more than testosterone.

PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from Eclipta Prostrata L.

research PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from <i>Eclipta prostrata</i> L.

6 citations , December 2020 in “Biological & Pharmaceutical Bulletin”

Compounds from Eclipta prostrata L. plant have diabetes and obesity-fighting properties and reduce inflammation.

ROBO4 Deletion Ameliorates PAF-Mediated Skin Inflammation by Regulating the mRNA Translation Efficiency of LPCAT1/LPCAT2 and the Expression of PAF Receptor

research ROBO4 deletion ameliorates PAF-mediated skin inflammation via regulating the mRNA translation efficiency of LPCAT1/LPCAT2 and the expression of PAF receptor

6 citations , January 2020 in “International journal of biological sciences”

Removing the ROBO4 gene in mice reduces skin inflammation and hair loss by affecting certain inflammation pathways and gene expression.

research Androgenic modulation of arterial baroreceptor dysfunction and neuroinflammation in endotoxic male rats

2 citations , February 2021 in “Brain Research”

Testosterone affects blood pressure control and inflammation in male rats with endotoxic shock, and blocking certain hormones may help treat it.

The Anti-Muscle Atrophy Effects of Ishige Sinicola in LPS-Induced C2C12 Myotubes Through Antioxidant and Anti-Inflammatory Actions

research The Anti-Muscle Atrophy Effects of Ishige sinicola in LPS-Induced C2C12 Myotubes through Its Antioxidant and Anti-Inflammatory Actions

1 citations , September 2023 in “Applied sciences (Basel)”

Ishige sinicola extract may help prevent muscle atrophy through its antioxidant and anti-inflammatory effects.

Cardiac and Brainstem Neuroinflammatory Pathways Account for Androgenic Incitement of Cardiovascular and Autonomic Manifestations in Endotoxic Male Rats

research Cardiac and brainstem neuroinflammatory pathways account for androgenic incitement of cardiovascular and autonomic manifestations in endotoxic male rats

1 citations , April 2021 in “Journal of Cardiovascular Pharmacology”

Testosterone plays a big role in heart and nervous system damage caused by inflammation in male rats, suggesting that blocking testosterone production could help manage this condition.

research 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis

April 2023 in “Journal of Investigative Dermatology”

PX-12 may help treat psoriasis by blocking inflammation and cell death.

Cardiac and Medullary Neuroinflammatory Pathways Trigger Androgenic Incitement of Cardiovascular Sequels of Endotoxemia in Rats

research Cardiac and Medullary Neuroinflammatory Pathways Trigger Androgenic Incitement of Cardiovascular Sequels of Endotoxemia in Rats

April 2020 in “The FASEB Journal”

Testosterone increases heart and blood pressure issues in rats with endotoxemia, and stopping testosterone production can reduce these problems.

research 196 The endocannabinoid tone regulates human sebocyte biology

August 2016 in “Journal of Investigative Dermatology”

The endocannabinoid system affects oil production and inflammation in skin cells.

research Inhibition of 5α-reductase of de novo Generation of Short Anti-oxidant Peptides

September 2018 in “Journal of Experimental & Biomedical Sciences”

DK peptides can reduce hair loss by inhibiting the 5α-reductase enzyme and have antioxidant effects.

research Anti-inflammatory effects on murine macrophages of ethanol extracts of Lygodium japonicum spores via inhibition of NF-κB and p38

5 citations , July 2017 in “Molecular Medicine Reports”

Lygodium japonicum spores can reduce inflammation by blocking certain cell signals.

Targeting Evasion of Immune Pathways in Glioblastoma

research TLRgeting Evasion of Immune Pathways in Glioblastoma

15 citations , April 2017 in “Cell Stem Cell”

Some brain cancer cells avoid immune system detection, and certain treatments could target this to slow their growth; also, certain fat cell precursors help regenerate hair and skin after injury.

research Remote photobiomodulation ameliorates behavioral and neuropathological outcomes in a rat model of repeated closed head injury

4 citations , January 2025 in “Translational Psychiatry”

Remote photobiomodulation improves brain injury outcomes and behavior in rats.

research Effects of Bioactive Composition in Oryza sativa L. cv. KDML105 Bran Extract on Gene Expression Related to Hair Cycle in Human Hair Follicle Dermal Papilla Cells

3 citations , January 2023 in “Agronomy”

KDML105 bran extract may help with hair growth and prevent hair loss.

research Unraveling the web of defense: the crucial role of polysaccharides in immunity

49 citations , October 2024 in “Frontiers in Immunology”

Polysaccharides boost immunity and could help prevent and treat diseases.

research Application of exopolysaccharides in cosmetics

January 2024 in “CRC Press eBooks”

Exopolysaccharides are safer and beneficial alternatives to harmful chemicals in cosmetics.

research Therapeutic potential of Sertoli cells in vivo: alleviation of acute inflammation and improvement of sperm quality

5 citations , September 2024 in “Stem Cell Research & Therapy”

Sertoli cell transplants can reduce inflammation and improve sperm quality.

research Spherical Nucleic Acids as Emerging Topical Therapeutics: A Focus on Psoriasis

6 citations , January 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

New topical treatment using spherical nucleic acids shows promise in reducing psoriasis inflammation.

research Purification and characterization of an immuno-stimulatory compound from the water extract of royoporus badius (Pers.) A.B. De.

January 2018

A new compound from Royoporus badius activates immune cells and induces inflammatory responses.

research Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19

70 citations , July 2020 in “Pharmacological Reports”

Cepharanthine, a Japanese hair loss drug, shows promise as a COVID-19 treatment but needs more testing.

Inhibition of 5α-Reductase, IL-6 Secretion, and Oxidation Process of Equisetum Debile Extract as Functional Food and Nutraceutical Ingredients

research Inhibition of 5α-Reductase, IL-6 Secretion, and Oxidation Process of Equisetum debile Roxb. ex Vaucher Extract as Functional Food and Nutraceuticals Ingredients

49 citations , October 2017 in “Nutrients”

Equisetum debile extract, especially the ethyl acetate type, may be a promising natural ingredient for anti-hair loss products.

research The Role of Vitamin D in Non-Scarring Alopecia

32 citations , December 2017 in “International Journal of Molecular Sciences”

Low vitamin D might be linked to certain types of hair loss, and supplements could help, but more research is needed.