research A regulatory perspective on pharmacokinetic/pharmacodynamic modelling
The document concludes that PK/PD modeling is important for determining the safe and effective dosages of drugs.
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research The probable destructive mechanisms behind COVID-19 on male reproduction system and fertility
COVID-19 may harm male fertility and damage the reproductive system.
research Teriflunomide: a novel oral treatment for relapsing multiple sclerosis
Teriflunomide is an effective and safe first-line oral treatment for relapsing multiple sclerosis.
research Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins
Fibroblasts can be mistaken for neural cells, so functional validation is needed.
research Symmetrical acrokeratoderma: A peculiar entity in China? Clinicopathologic and immunopathologic study of 34 new cases
Symmetrical Acrokeratoderma (SAK) may be a unique skin condition in China, lacking specific treatment and needing long-term monitoring.
research Polycystic Ovary Syndrome
Women with PCOS-related infertility can often conceive with treatments like clomiphene and metformin, but managing pregnancy complications is important.
research Immunomodulators in the treatment of cutaneous lymphoma
Immunomodulatory therapies are effective for treating cutaneous lymphoma, particularly in early stages.
research Repurposing steroidogenesis inhibitors for the therapy of neuropsychiatric disorders: Promises and caveats
Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.
research The rise of transcutaneous drug delivery for the management of alopecia: a review of existing literature and an eye towards the future
Using methods like lasers and microneedling with drugs can improve hair regrowth for alopecia, but more research is needed on safety and best practices.
research Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus
Topical calcineurin inhibitors, especially 0.1% tacrolimus ointment, are effective and well-tolerated for treating cutaneous lupus erythematosus but require more research for standard treatment guidelines.
research Methodology and Challenges to Recruitment to a Randomized, Double-Blind, Placebo-Controlled Trial of Oral DHEA in Postmenopausal Women
Researchers had trouble finding enough participants for a trial on DHEA's effects on postmenopausal women's sexual desire.
research Functional ectodermal organ regeneration as the next generation of organ replacement therapy
The document concludes that regenerating functional ectodermal organs like teeth and hair is promising for future therapies.
research Testosterone Treatment in Women – An Overview
Testosterone treatment can improve sexual function and bone density in women but may have adverse effects and requires more research on safety and guidelines.
research Medical consequences of long-term anabolic-androgenic Steroids (AASs) abuses in athletes
Long-term steroid abuse in athletes causes serious health risks, outweighing any benefits.
research Immunosuppressive therapy in autoimmune disease — A review
Immunosuppressive therapy helps manage autoimmune diseases but carries risks like infection and potential for malignancy.
research Finasteride for hair loss: a review
Finasteride helps hair growth but may cause sexual side effects and depression.
research Renal Vitamins
Dialysis patients benefit from water-soluble vitamins but need careful management to avoid risks.
research Management of hidradenitis suppurativa
Effective treatment for hidradenitis suppurativa varies, with antibiotics commonly used and surgery as an option, but no single method is universally successful.
research Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite
Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.
research Dermatology and Pregnancy
Pregnancy can cause skin changes and affect existing skin conditions, with limited treatment options due to the need for fetal safety.
research Advances in nanomaterial-mediated CRISPR/Cas delivery: from lipid nanoparticles to vesicle-derived systems
Ionizable lipid nanoparticles are the best for delivering gene-editing therapies.
research Comprehensive Overview - Outcomes and Challenges of Bariatric Surgery - Physical, Psychological and Nutritional Considerations
Bariatric surgery helps with weight loss but can cause physical and mental health challenges.
research The Coexistence of Trachyonychia and Mucocutaneous Lichen Planus: A Case Report
Early diagnosis and treatment of nail and skin conditions can improve health and appearance.
research Mechanisms of impairment in hair and scalp induced by hair dyeing and perming and potential interventions
Hair dyes and perms can damage hair and scalp, but using interventions can reduce harm.
research Hypertension and Cicatricial Hair Loss: Defining High Value Symptom Clusters within Reproductive Aging
Women with cicatricial hair loss may have a higher risk of hypertension.
research Female Antiandrogens
Antiandrogens can treat female hormonal conditions, but environmental ones may harm reproductive health.
research Why Do Promising Therapies Stall in Development and How Can We Move Them Forward?
Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.
research Clinical Evaluation of Women Presenting with Low Libido and Determination of Whether Androgen Therapy Might Be Appropriate
Androgen therapy might help some women with low libido, but it has risks and should be used carefully.
research SARS-CoV-2 infection reduces the number of spermatogonial stem cells and dysregulates the transcriptional landscape of the human testis
COVID-19 can harm male fertility by reducing sperm stem cells and damaging testicular function.
research DUTASTERIDE AS AN EFFECTIVE TREATMENT IN ANDROGENETIC ALOPECIA – A LITERATURE REVIEW
Dutasteride is more effective than finasteride for hair loss, but more research is needed on safety and dosing.