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Did you mean Lipid Accumulation?

GlossaryLipid Accumulation

excessive fat build-up within cells or tissues

Lipid accumulation, also known as fat accumulation, refers to the build-up of lipids (fats) within cells or tissues. This process can occur in various parts of the body, including the liver, muscles, and skin, and is often associated with metabolic disorders such as obesity, diabetes, and cardiovascular diseases. In the context of hair and alopecia, excessive lipid accumulation in the scalp can potentially disrupt normal hair follicle function, contributing to hair loss.

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Clinical Usefulness of Non-Invasive Metabolic-Associated Fatty Liver Disease Risk Assessment Methods in Patients with Polycystic Ovary Syndrome in Relation to MRI Examination with the Ideal IQ Sequence

research Clinical Usefulness of Non-Invasive Metabolic-Associated Fatty Liver Disease Risk Assessment Methods in Patients with Full-Blown Polycystic Ovary Syndrome in Relation to the MRI Examination with the Ideal IQ Sequence

September 2022 in “Biomedicines”

Lipid Accumulation Product and Free Androgens Index are effective for assessing fatty liver disease risk in women with Polycystic Ovary Syndrome.

Cedrol Mitigates Hepatic Lipid Accumulation and Adipocyte Hypertrophy Induced by Corticosteroids Through the Inhibition of Glucocorticoid Receptor Activity

research Cedrol mitigates hepatic lipid accumulation and adipocyte hypertrophy induced by corticosteroids through the inhibition of glucocorticoid receptor activity

December 2025 in “Scientific Reports”

Cedrol may help reduce liver fat and fat cell growth caused by corticosteroids.

research Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm

17 citations , January 2020 in “The World Journal of Men's Health”

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

research Rodent models in placental research. Implications for fetal origins of adult disease

7 citations , January 2022 in “Animal Reproduction”

Using rodents for research shows that health problems in the womb can cause diseases later in life.

research Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk

102 citations , July 2007 in “Genes & Development”

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

research Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5

18 citations , June 2017 in “Proceedings of the National Academy of Sciences of the United States of America”

A gene called Gk5 controls lipid production in the skin and affects hair growth.

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

September 2020 in “Research Square (Research Square)”

Enhanced stem cells from the placenta can reduce fat buildup in eye tissue for Graves' disease.

research Glucocorticoid Receptor Antagonism Improves Glucose Metabolism in a Mouse Model of Polycystic Ovary Syndrome

December 2023 in “Journal of the Endocrine Society”

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

research The Acute Toxicity of 2,3,4,7,8-Pentachlorodibenzofuran (4PeCDF) in the Male Fischer Rat

January 1988 in “Toxicological Sciences”

4PeCDF is highly toxic to male rats, causing weight loss, organ damage, and death.

Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated With Androgenetic Alopecia in Adults With Stronger Effects in Women and Unhealthy Lifestyles

research Metabolic dysfunction-associated steatotic liver disease is associated with androgenetic alopecia in adults with stronger effects in women and unhealthy lifestyles

November 2025 in “Scientific Reports”

Liver disease is linked to hair loss, especially in women and those with unhealthy lifestyles.

research Pure linoleate deficiency in the rat: influence on growth, accumulation of n-6 polyunsaturates, and [1-14C]linoleate oxidation

109 citations , April 1997 in “Journal of Lipid Research”

Linoleate deficiency in rats reduces growth and n-6 polyunsaturate accumulation, causing mild symptoms.

research Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver

59 citations , May 2017 in “Scientific reports”

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

Long-Term Dutasteride Therapy in Men with Benign Prostatic Hyperplasia Alters Glucose and Lipid Profiles and Increases Severity of Erectile Dysfunction

research Long-term dutasteride therapy in men with benign prostatic hyperplasia alters glucose and lipid profiles and increases severity of erectile dysfunction

20 citations , June 2017 in “Hormone Molecular Biology and Clinical Investigation”

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

Metabolic Syndrome – A New Definition and Management Guidelines: A Joint Position Paper by Various Polish Medical Societies

research Metabolic syndrome – a new definition and management guidelines A joint position paper by the Polish Society of Hypertension, Polish Society for the Treatment of Obesity, Polish Lipid Association, Polish Association for Study of Liver, Polish Society of Family Medicine, Polish Society of Lifestyle Medicine, Division of Prevention and Epidemiology Polish Cardiac Society, “Club 30” Polish Cardiac Society, and Division of Metabolic and Bariatric Surgery Society of Polish Surgeons

20 citations , August 2022 in “Archives of Medical Science”

The Polish medical societies have redefined metabolic syndrome and recommend lifestyle changes, certain medications, and possibly bariatric surgery for treatment. They also discuss managing related health conditions.

research The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

October 2022 in “Biomedicines”

Finasteride in male rats causes liver and metabolic issues in their offspring.

research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

31 citations , January 2017 in “Advances in Experimental Medicine and Biology”

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

research Elevated fasting insulin is associated with cardiovascular and metabolic risk in women with polycystic ovary syndrome

17 citations , May 2019 in “Diabetes and Metabolic Syndrome: Clinical Research and Reviews”

High fasting insulin levels in women with PCOS are linked to a higher risk of heart and metabolic problems.

research Metabolic dysfunction in female mice with disruption of 5α-reductase 1

11 citations , January 2017 in “Journal of Endocrinology/Journal of endocrinology”

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

research Potential adverse effects of long-term testosterone therapy

72 citations , October 1998 in “Baillière's clinical endocrinology and metabolism”

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Effective Amelioration of Hepatic Inflammation and Insulin Response in High-Fat Diet-Fed Rats via Regulating AKT/mTOR Signaling: Role of Lepidium Sativum Seed Extracts

research Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts

14 citations , October 2020 in “Journal of ethnopharmacology”

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

Localization and Regulation of Cholesterol Transporters in the Human Hair Follicle: Mapping Changes Across the Hair Cycle

research Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle

13 citations , January 2021 in “Histochemistry and Cell Biology”

Cholesterol transport in hair follicles decreases from growth to regression phase.

research Safety Considerations and Monitoring in Patients Treated with Systemic Medications for Acne

10 citations , January 2016 in “Dermatologic Clinics”

Some acne medications have side effects; doctors should educate patients and may not need to do frequent lab tests for all.

Unraveling the Link Between Insulin Resistance and Androgen Excess

research Unravelling the link between insulin resistance and androgen excess

December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)”

AKR1C3 could be a treatment target for metabolic issues in PCOS.

research Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress

88 citations , August 2014 in “PLOS genetics”

Syndecan-1 is essential for maintaining skin fat and preventing cold stress.

research Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells

20 citations , October 2017 in “Stem Cell Reports”

Alkaline Ceramidase 1 prevents early hair loss in mice by keeping hair follicle stem cells balanced.

research Comparative characterization and osteogenic / adipogenic differentiation of mesenchymal stem cells derived from male rat hair follicles and bone marrow

6 citations , August 2020 in “Cell regeneration”

Hair follicle stem cells are similar to bone marrow stem cells but are better for fat cell research.

research Metabolic Aspects of Polycystic Ovary Syndrome

August 2015 in “Postgraduate obstetrics & gynecology”

Women with PCOS often have insulin resistance, abnormal lipid levels, and a higher risk of diabetes and heart disease; lifestyle changes and medication like metformin can help manage these risks.

research Metabolic Aspects of Polycystic Ovary Syndrome

August 2015 in “Postgraduate obstetrics & gynecology”

Women with PCOS often have metabolic issues like insulin resistance and a higher risk of diabetes and abnormal lipid levels.

Inhibition of Autophagy-Lysosomal Function Exacerbates Microglial and Monocyte Lipid Metabolism Reprogramming and Dysfunction After Brain Injury

research Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury

September 2025

Blocking autophagy worsens lipid buildup and dysfunction in brain cells after injury.

The Expression of the Gene Aseb in the Laboratory Mouse: Sebaceous Glands

research The expression of the gene asebia in the laboratory mouse: 3. Sebaceous glands

16 citations , April 1978 in “Genetics Research”

Mice with the ab gene have abnormal sebaceous gland development, affecting sebum production.