research Modulation of glucocorticoid action and the treatment of type-2 diabetes
Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.
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30-60 / 1000+ results research Collective heterogeneity of mitochondrial potential in contact inhibition of proliferation
Mitochondrial activity varies in cells before they stop growing, affecting their growth potential.
research An integrative view of mammalian seasonal neuroendocrinology
The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.
research Expression of steroidogenic enzymes in human sebaceous glands
Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.
research Idiopathic Hirsutism*
The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.
research Epidermal Stem Cells in Wound Healing and Regeneration
Epidermal stem cells help heal skin, but how they work is still unclear.
research Endocrine systems of the skin
The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.
research Unraveling the Molecular Mechanism of Bider Marking Formation in Dun Mongolian Horses Through Transcriptome Sequencing
"Bider" markings in Dun Mongolian horses are caused by a complex network of genes and pathways.
research In vivo evidence for an increase in 5alpha‐reductase activity in the rat central nervous system following morphine exposure
Morphine increases testosterone breakdown in the rat brain and spinal cord.
research 11β-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes
Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.
research Topical Antiandrogens
Topical antiandrogens might treat skin issues like hair growth, balding, and acne, but finding effective treatments without side effects is challenging.
research [Hirsutism and hypertrichosis in adults: investigations and treatment].
The document concludes that treatment for excessive hair growth depends on the cause, with options including hair removal methods and medications like anti-androgens or insulin-sensitizing drugs.
research Highlights
Melanoma patients can learn to check their skin, early balding in men may indicate similar risks as PCOS in women, certain criteria can help predict skin cancer behavior, small skin cancer may not need extra therapy after surgery, and sterile gloves don't reduce infection in minor surgeries.
research Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease
Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.
research Alopecia: Association with Resistance to Thyroid Hormones
A specific thyroid hormone resistance mutation may be linked to different types of hair loss.
research Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine
Dyclonine can effectively reduce skin issues by inhibiting the TRPV3 channel.
research Prostaglandin metabolism in human hair follicle
Human hair follicles can make and process prostaglandins, which may affect hair growth.
research Altered brain and pituitary androgen metabolism by prenatal, perinatal or pre- and postnatal finasteride, flutamide or dihydrotestosterone treatment in juvenile male rats
Treatment during development affects hormone balance and sexual behavior in male rats.
research Skin and glucocorticoids: effects of local skin glucocorticoid impairment on skin homeostasis
Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.
research Metabolism and skin diseases
Skin health and diseases are closely linked to metabolic processes.
research To study hypoactive sexual desire disorder in a fragile X carrier female successfully treated with local testosterone application
Local testosterone treatment improved sexual desire in a female with fragile X syndrome.
research ANDROGEN METABOLISM AS IT AFFECTS HAIR GROWTH IN ANDROGENETIC ALOPECIA
Androgens, like DHT, affect hair growth and treatments like finasteride may help.
research Cutaneous Androgen Metabolism: Basic Research and Clinical Perspectives
Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
research Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes
Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.
research Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle
Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.
research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity
Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.
research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men
Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.
research Mesotherapy for local fat reduction
Mesotherapy might help reduce fat in specific areas for those close to their ideal weight, but more research and care are needed to ensure safety.
research The Metabolism and Control Mechanism of Human Hair Follicles
Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.
research The Role of Non-Aromatizable Testosterone Metabolite in Metabolic Pathways
Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.