Search

for
Search:

Sort by

Research

420-450 / 1000+ results

RPGRIP1L Facilitates Desmosomal Adhesion Through Suppressing PKCβII-Mediated Desmoglein Endocytosis: Implication in Pemphigus

research 441 RPGRIP1L facilitates desmosomal adhesion through suppressing PKCβII-mediated desmoglein endocytosis: Implication in pemphigus

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

RPGRIP1L helps skin cells stick together by blocking PKCβII, which can prevent skin blistering like in pemphigus.

research A Girl with a Novel Splice Site Mutation in <i>VDR</i> Supports the Role of a Ligand-Independent VDR Function on Hair Cycling

21 citations , January 2006 in “Hormone Research in Paediatrics”

A mutation in the VDR gene affects hair cycling without needing ligand binding.

research Isolation and Molecular Cloning of Epidermal- and Hair Follicle-Specific Peptidylarginine Deiminase (Type III) from Rat

42 citations , May 1997 in “The Journal of Biochemistry”

PAD type III enzyme is specific to rat skin and hair follicles.

research Abstract 151

April 2015 in “Plastic and Reconstructive Surgery”

Activating TLR3 helps improve skin and hair follicle regeneration after wounds.

research Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse

232 citations , January 2002 in “Mechanisms of development”

Different enzymes are active in different parts of developing mouse organs.

research LncRNA MSTRG.14227.1 regulates the morphogenesis of secondary hair follicles in Inner Mongolia cashmere goats via targeting ADAMTS3 by sponging chi-miR-433

3 citations , December 2024 in “Journal of Animal Science”

LncRNA MSTRG.14227.1 hinders hair follicle development in cashmere goats, affecting cashmere quality.

research Decision letter: Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

October 2016

Deleting the MAD2L1 gene in mice led to rapid tumor growth despite chromosomal instability.

research Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis

52 citations , September 2012 in “Oncogene”

research Regeneration of a bioengineered 3D integumentary organ system from iPS cells

12 citations , April 2019 in “Nature protocols”

Scientists created a functional 3D skin system from stem cells that can be transplanted into wounds.

research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

Using special RNA to target a mutant gene fixed hair problems in mice.

research Itpr3 Is Responsible for the Mouse Tufted (tf) Locus

6 citations , October 2012 in “Journal of Heredity”

The Itpr3 gene causes a specific hair pattern in mice.

research Read-Through for Nonsense Mutations in Type XVII Collagen‒Deficient Junctional Epidermolysis Bullosa

5 citations , April 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

A new therapy for a skin blistering condition has not been developed yet.

research 937 Disruption of the innate lymphoid cell network alters the hair cycle during induced anagen

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Removing certain immune cells in mice causes their hair to enter the growth phase earlier than usual.

research Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter

52 citations , October 2007 in “Molecular Therapy”

Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.

research 42004 Scalp, eyebrow, and eyelash hair regrowth with continued ritlecitinib treatment among patients with alopecia areata without target efficacy response at Week 24: post hoc analysis of the ALLEGRO phase 2b/3 study

1 citations , September 2023 in “Journal of the American Academy of Dermatology”

This post hoc analysis of the ALLEGRO phase 2b/3 study evaluated the efficacy of ritlecitinib, an oral JAK3/TEC inhibitor, in patients with alopecia areata (AA) who did not meet target efficacy response criteria at Week 24. The study included patients aged 2-12 years with at least 50% scalp hair loss. Results showed that among those who did not respond by Week 24, 8-14% achieved a response by Week 28, increasing to 22-34% by Week 48. Similar improvements were observed for eyebrow and eyelash assessments. Ritlecitinib was well tolerated, with common adverse events including upper respiratory tract infection, nasopharyngitis, and headache. The findings suggest that continued ritlecitinib treatment may lead to hair regrowth in patients who initially do not respond.

K15 Promoter-Driven Enforced Expression of NKIRAS Exhibits Tumor Suppressive Activity Against the Development of DMBA/TPA-Induced Skin Tumors

research K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors

4 citations , October 2021 in “Scientific Reports”

NKIRAS2 can suppress certain skin tumors but its effect on cancer varies with context and expression level.

research Role of ASLNC168501 in regulating hair follicle stem cell activity via the AR/miR-128-3p/IGF-1 pathway

January 2026 in “Stem Cell Research & Therapy”

ASLNC168501 can help treat hair loss by restoring hair follicle stem cell function.

research Lentiviral Vector-Mediated Gene Transfer to Human Hair Follicles

6 citations , February 2009 in “Journal of Investigative Dermatology”

WISP-1 Induced by Mechanical Stress Contributes to Fibrosis and Hypertrophy of the Ligamentum Flavum Through Hedgehog-Gli1 Signaling

research WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

36 citations , June 2021 in “Experimental & Molecular Medicine”

Targeting Hedgehog signaling may help treat ligamentum flavum fibrosis.

research Author response: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium

December 2020

The balance between cell renewal and differentiation controls the growth of cancerous cells in mouse skin.

research The mouse frizzy (fr) and rat ‘hairless’ (fr^CR) mutations are natural variants of protease serine S1 family member 8 (Prss8)

28 citations , February 2010 in “Experimental Dermatology”

The frizzy mouse and hairless rat mutations are due to changes in the Prss8 gene.

research A Multiaxial Bioreactor Integrated with an Environmental Monitoring System for Tissue‐Engineered Skin Grafts

January 2026 in “Advanced Healthcare Materials”

The new bioreactor improves skin grafts by evenly stretching cells and monitoring conditions for better growth.

research 565 Cutaneous delivery of LEKTI via an engineered strain of staphylococcus epidermidis for the treatment of netherton syndrome

July 2024 in “Journal of Investigative Dermatology”

ATR12-351 ointment safely delivers LEKTI protein to the skin, reducing enzyme activity in Netherton syndrome.

research Integrated Safety Analysis of Ritlecitinib in Adolescent Patients with Alopecia Areata from the Randomized, Placebo-Controlled ALLEGRO Phase 2b/3 and Ongoing Open-Label Phase 3 ALLEGRO-LT Studies

1 citations , November 2023 in “SKIN The Journal of Cutaneous Medicine”

research RBPJ Mutations Identified in Two Families Affected by Adams-Oliver Syndrome

112 citations , August 2012 in “The American Journal of Human Genetics”

Mutations in the RBPJ gene cause Adams-Oliver Syndrome.

research Long‐term safety and efficacy of ritlecitinib in adults and adolescents with alopecia areata and at least 25% scalp hair loss: Results from the ALLEGRO‐LT phase 3, open‐label study

15 citations , January 2025 in “Journal of the European Academy of Dermatology and Venereology”

Ritlecitinib is effective and safe for treating alopecia areata, promoting significant hair regrowth.

research Lgr6+ cells in the biological system during homeostasis and injury

September 2025 in “Genes & Diseases”

Lgr6+ cells are important for tissue repair and could be a target for treating cancer and other diseases.

research Transcriptional regulation analysis and the potential transcription regulator site in the extended KAP6.1 promoter in sheep

5 citations , July 2014 in “Molecular Biology Reports”

research The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis

19 citations , March 2022 in “Molecular therapy. Nucleic acids”

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

research Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

64 citations , February 2008 in “Cancer Research”

Inactivating both p53 and Rb genes in mice speeds up aggressive skin cancer development.

← Previous page Next page →