research The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region
Proteolytic enzymes damaged hair follicle stem cells in transgenic mice.
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870-900 / 1000+ resultsresearch Retinoic acid and dimethyl sulfoxide promote efficient delivery of transgenes to mouse skin by topically transdermal penetration
Retinoic acid and DMSO improve gene delivery to mouse skin for potential hair and skin disease treatment.
research Immunohistochemical expressions of mGluR5, P2Y2 receptor, PLC-?1, and IP3R-I and -II in Merkel cells in rat sinus hair follicles
research 3D cell culture stimulates the secretion of in vivo like extracellular vesicles
3D cell cultures produce extracellular vesicles similar to those in the body.
research Lactate dehydrogenase activity drives hair follicle stem cell activation
Lactate production is important for activating hair growth stem cells.
research Treatment of Cystathionine β-Synthase Deficiency in Mice Using a Minicircle-Based Naked DNA Vector
MC-DNA vector-based gene therapy can temporarily treat CBS deficiency in mice.
research A high-performance liquid chromatography–tandem mass spectrometry assay of the androgenic neurosteroid 3α-androstanediol (5α-androstane-3α,17β-diol) in plasma
Testosterone increases 3α-androstanediol levels, which can be blocked by finasteride.
research Determining hair shine from laser-light reflection of human hair fibers
Hair shine can be measured by how it reflects laser light.
research Determination of finasteride in human plasma by LC-MS and its pharmacokinetics
The method accurately measures finasteride in plasma, and the test tablets are as effective as the reference ones.
research Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles
The study found a specific peptide that helps detect TGase 3 activity in skin and hair follicles.
research Novel enzymatic assay predicts minoxidil response in the treatment of androgenetic alopecia
New test predicts if hair loss treatment will work.
research All Subcomponents of the Cutaneous Lupus Erythematosus Disease Area and Severity Index–Activity (CLASI-A) are Relevant to Identify and Detect Changes in Skin Activity
All parts of the CLASI-A score are important for assessing skin activity in cutaneous lupus erythematosus.
research Author response: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium
The balance between cell renewal and differentiation controls the growth of cancerous cells in mouse skin.
research Confocal Laser Scanning Microscopy: An Excellent Tool for Tracking Compounds in the Skin
Confocal Laser Scanning Microscopy is effective for tracking compounds in the skin.
research Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
research Intravital longitudinal wide-area imaging of dynamic bone marrow engraftment and multilineage differentiation through nuclear-cytoplasmic labeling
Transplanted bone marrow cells actively move, form clusters, and grow after transplantation.
research Colorimetry provides a rapid objective measurement of de novo hair growth rate in mice
Colorimetry can accurately measure hair growth rates in mice.
research P140 Light-emitting diode light regulates the proliferation of human outer root sheath cells via Wnt/β -catenin and ERK pathway
LED light promotes hair growth by stimulating cell proliferation and reducing cell death.
research Chaperones as thermodynamic sensors
New cancer treatments show promise in reducing tumor growth and improving skin regeneration in mice.
research Dual Wavelength LEDs Induce Reactive Oxygen Species and Nitric Oxide That Inhibit the Production of Dihydrotestosterone by 5‐α Reductase
Dual wavelength LEDs may help reduce hair loss by lowering DHT levels.
research FOXE1, A New Transcriptional Target of GLI2 Is Expressed in Human Epidermis and Basal Cell Carcinoma
research Novel Application of Layered Expression Scanning for Proteomic Profiling of Plucked Hair Follicles
A new method for studying hair follicles is easier and more precise, useful for hair loss and cancer treatment research.
research 1465 Optimization/characterization of a Focal Dermal Hypoplasia mouse model to test potential treatments
Li2CO3 improved skin disease in a mouse model of Focal Dermal Hypoplasia without toxicity.
research Fluorine-Induced Apoptosis and Lipid Peroxidation in Human Hair Follicles In Vitro
research A rapid screening LC‐MS/MS method based on conventional HPLC pumps for the analysis of low molecular weight xenobiotics: application to doping control analysis
A quick method was developed to detect banned substances in urine for doping control.
research The patch assay reconstitutes mature hair follicles by culture-expanded human cells
The patch assay can create mature hair follicles from human cells and may help in hair loss treatments.
research Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
Activated LEF/TCF complexes are crucial for hair development and cycling.
research Low‐level laser activates Wnt/β‐catenin signaling pathway‐promoting hair follicle stem cell regeneration and wound healing: Upregulate the expression of key downstream gene Lef 1
Low-level laser therapy can boost hair growth and speed up wound healing.
research Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
The method quickly analyzes hair growth genes and shows that blocking Smo in skin cells stops hair growth.
research Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis
Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.