research N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting
Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.
Search
for
Sort by
Research
390-420 / 1000+ results 
research 1430 Modeling the onset of senescence associated secretory phenotype predicts therapeutic targets
The research found that blocking a gene called NEMO can potentially prevent harmful effects of aging at the cellular level.
research 559 Induction of tissue-specific premature stem cell aging promotes senescence-like phenotypes in remote multiple organs
Aging in one type of stem cell can cause aging-like changes in various organs.
research The therapeutic promise of apoptosis
Blocking cell death in certain stem cells can improve wound healing and tissue regeneration.
research Image 3_Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata.tif
Linoleic acid and magnesium are key in alopecia areata progression, and tofacitinib can help by affecting their pathway.
research Valproic acid boosts hair follicle stem cell resilience to oxygen-glucose deprivation through autophagy induction and AKT/mTOR suppression
Valproic acid helps hair follicle stem cells survive better in low oxygen and glucose conditions.
research Hair repigmentation in microcystic adnexal carcinoma
Hair repigmentation can indicate malignancy and should be investigated.
research Multi-omics empowered deep phenotyping of ulcerative colitis
Ulcerative colitis involves immune activation, chronic inflammation, and metabolic issues, some of which persist even during remission.
research Alopecia Areata, Primary Sclerosing Cholangitis, and Ulcerative Colitis: Autoimmunity and Apoptosis as Common Links?
The conditions alopecia areata, primary sclerosing cholangitis, and ulcerative colitis may be linked by shared autoimmune and cell death mechanisms.
research Alopecia and hair repigmentation associated with anti-programmed death-ligand 1 (PD-L1) immunotherapy
research Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk
Skin tumor regression is helped by retinoic acid signaling blocking Wnt signaling.
research 1393 Human TMEM2 is not a hyaluronidase but a regulator of hyaluronan metabolism
Human TMEM2 does not break down hyaluronan but helps control its metabolism.
research Mechanism of Apoptotic Regulation of Follicular Regression
The document concludes that understanding how hair follicles naturally die and regenerate is important for insights into organ development and could impact health and disease treatment.
research Study of alpha mangostin as a chemoprotective agent for breast cancer via activation of the p53 pathway
Alpha mangostin may protect certain breast cancer cells by activating the p53 pathway.
research Premature aging syndromes: From patients to mechanism
Studying premature aging syndromes helps understand human aging and suggests potential treatments.
research Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche
Hair graying is caused by the loss of pigment cells due to poor maintenance of stem cells in the hair follicle.
research The compatibility of Bacillus thuringiensis Cry protein-solubilizing buffers with the droplet feeding method in fall armyworm larvae
Thymosin beta 4 protects cells from damage by blocking a harmful microRNA and boosting a protective gene.
research Elevated Mammalian Target of Rapamycin (mTOR) Gene Expression in Acne Vulgaris patients
Acne patients have higher mTOR gene expression.
research Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata
Targeting gut microbiome and metabolome may help treat autoimmune skin diseases like alopecia areata.
research Degradation of human hair keratin scaffold material used to repair injured skeletal muscles of rabbits
Human hair keratin scaffold material degrades in muscles mainly through the ubiquitin system with lysosome help.
research Skin aging: are adipocytes the next target?
Targeting dermal adipocytes may help combat skin aging.
research Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis
Two distinct caspases in human skin help with cell death and skin formation.
research Apoptosis in follicles of individuals with female pattern hair loss is associated with perifollicular microinflammation
Hair loss in women links to inflammation around hair follicles.
research The potential impact of melanosomal pH and metabolism on melanoma
Melanin may help melanoma cells grow by aiding their metabolism.
research Macrophage ferroportin is essential for stromal cell proliferation in wound healing
Macrophage iron release is crucial for hair growth and wound healing.
research Is knowledge about the genetic and epigenetic alterations in melanoma a basis for targeted therapy?
Targeting multiple pathways and understanding genetic mutations are crucial for effective melanoma therapy.
research Oncogenic senescence: a multi-functional perspective
Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.
research Synthetically programmed antioxidant delivery by a domesticated skin commensal
Engineered bacteria can deliver antioxidants to protect skin.
research Peroxisome proliferator-activated receptor-γ signalling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial–mesenchymal transition
Activating PPAR-γ signalling can protect hair follicle stem cells from damage caused by chemotherapy.
research 1370 MTORC1 activity is increased in the skin of acne patients and is suppressed with isotretinoin treatment
Acne patients have higher skin mTORC1 activity, which is reduced by isotretinoin treatment.