Search

for
Search:

GlossaryMacrophage Polarization

process where immune cells change roles based on signals

Macrophage polarization refers to the process by which macrophages, a type of immune cell, change their functional state in response to different signals in their environment. They can adopt a pro-inflammatory state (M1) to fight infections or a healing state (M2) to repair tissues. This ability to switch roles is crucial for maintaining balance in the immune system and is important in conditions like infections, cancer, and autoimmune diseases.

Related Terms

Sort by

Research

30 / 1000+ results

Bioactive Anti-Inflammatory Antibacterial Hemostatic Citrate-Based Dressing With Macrophage Polarization Regulation for Accelerating Wound Healing and Hair Follicle Neogenesis

research Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis

61 citations , September 2020 in “Bioactive Materials”

A special dressing called FEA-PCEI can speed up wound healing, reduce scars, and help grow new hair follicles, but only at the right dosage.

research Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

20 citations , January 2022 in “Oxidative Medicine and Cellular Longevity”

Reactive oxygen species (ROS) influence hair growth by causing DNA damage, cell death, and changes in immune cells.

research Macrophage Polarization: A Novel Target and Strategy for Pathological Scarring

4 citations , October 2024 in “Tissue Engineering and Regenerative Medicine”

research CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation

3 citations , June 2025 in “Journal of Cellular and Molecular Medicine”

CuATSM speeds up wound healing and reduces scarring.

Human Adipose Tissue-Derived Small Extracellular Vesicles Promote Soft Tissue Repair Through Modulating M1-To-M2 Polarization Of Macrophages

research Human adipose tissue-derived small extracellular vesicles promote soft tissue repair through modulating M1-to-M2 polarization of macrophages

2 citations , April 2023 in “Stem Cell Research & Therapy”

Tiny fat-derived particles can help repair soft tissues by changing immune cell types.

research Cedrol from Platycladus orientalis (L.) Franco regulates M1/M2 polarization of macrophages and promotes hair regeneration

January 2026 in “Journal of Ethnopharmacology”

Cedrol promotes hair growth better than baricitinib by regulating immune cells.

research Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa

22 citations , August 2021 in “Frontiers in medicine”

Immune cells in Hidradenitis suppurativa become more inflammatory and may be important for treatment targets.

ADM Scaffolds Generate a Pro-Regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

research ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

17 citations , June 2018 in “Frontiers in Physiology”

ADM scaffolds help skin heal by promoting a healing-type immune response.

Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and miRNAs, and Sustained Release Formulation

research Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation

40 citations , March 2022 in “Small”

Hydrogel with M2-derived exosomes improves wound healing by slowly releasing exosomes that help reduce inflammation and promote tissue repair.

research Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds

18 citations , December 2021 in “Journal of Nanobiotechnology”

The nanofibers effectively treated infected diabetic wounds by killing bacteria and aiding wound healing without toxicity.

research Dual-Action Icariin-Containing Thermosensitive Hydrogel for Wound Macrophage Polarization and Hair-Follicle Neogenesis

6 citations , June 2022 in “Frontiers in Bioengineering and Biotechnology”

The gel with icariin speeds up wound healing, reduces scarring, and helps hair growth by controlling BMP4 signaling. It also reduces inflammation and improves wound quality in mice, adapts to different wound shapes, and gradually releases icariin to aid healing. It also prevents too much collagen and myofibroblast formation during skin healing.

research Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

222 citations , August 2014 in “Cell Metabolism”

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.

research Cepharanthine attenuates pulmonary fibrosis via modulating macrophage M2 polarization

6 citations , September 2024 in “BMC Pulmonary Medicine”

Cepharanthine may help treat lung fibrosis by affecting certain immune cells.

research Effect of injectable calcium alginate-amelogenin hydrogel on macrophage polarization and promotion of jaw bone osteogenesis

July 2023

The hydrogel helps bone growth and healing in jaw and facial defects.

research Xinyang tablet ameliorates sepsis-induced myocardial dysfunction by regulating Beclin-1 to mediate macrophage autophagy and M2 polarization through LncSICRNT1 targeting E3 ubiquitin ligase TRAF6

6 citations , November 2023 in “Chinese Medicine”

Xinyang Tablet improves heart function in sepsis by reducing inflammation.

research Activation of Astrocytes <i>in Vitro</i> by Macrophages Polarized with Keratin Biomaterial Treatment

6 citations , January 2016 in “Open journal of regenerative medicine”

Keratin treatment reduces astrocyte reactivity and inflammation.

research 26SCS-Loaded SilMA/Col Composite Sponge with Well-Arranged Layers Promotes Angiogenesis-Based Diabetic Wound Repair by Mediating Macrophage Inflammatory Response

April 2024 in “Molecules/Molecules online/Molecules annual”

The composite sponge helps heal diabetic wounds by reducing inflammation and promoting new blood vessel growth.

research The role of skin macrophages under conditions of stress and injury: ultraviolet irradiation and wound healing

December 2018

Inhibiting IL-17 and IL-23 improves wound healing in obese, diabetic mice by promoting healing macrophages.

research Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair

January 2026 in “Burns & Trauma”

NLRP3 helps control inflammation and repair in wound healing, making it a potential target for treatment.

research 3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis

22 citations , November 2024 in “Bioactive Materials”

3D bioprinting with special hydrogels helps heal wounds and grow new blood vessels.

research M2 Macrophage and Extracellular Matrix Genes Are Enriched in High‐Activity Lichen Planopilaris

January 2025 in “Dermatology Research and Practice”

Higher activity in lichen planopilaris is linked to certain immune and tissue genes.

research Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing

81 citations , March 2022 in “Frontiers in Bioengineering and Biotechnology”

Bioengineered scaffolds help heal skin wounds, but perfect treatments are still needed.

research An injectable bioactive dressing based on platelet-rich plasma and nanoclay: Sustained release of deferoxamine to accelerate chronic wound healing

62 citations , November 2022 in “Acta Pharmaceutica Sinica B”

The injectable hydrogel effectively speeds up chronic wound healing.

research Multifunctional and immunoregulatory microenvironment-responsive hydrogel for whole course management of infected diabetic wounds

10 citations , August 2024 in “Chemical Engineering Journal”

The ATAN-Met hydrogel helps heal infected diabetic wounds by promoting tissue regeneration and fighting bacteria.

Epigenetic Orchestration of RNA m6A Methylation in Wound Healing and Post-Wound Events

research Epigenetic orchestration of RNA m⁶A methylation in wound healing and post-wound events

3 citations , July 2025 in “International Journal of Biological Sciences”

m⁶A methylation is crucial for proper wound healing and tissue repair.

research Innervated Biomaterials for Improved Cutaneous Wound Healing: A Review of Recent Advancements and Future Prospects

2 citations , June 2025 in “International Journal of Nanomedicine”

New biomaterials can improve wound healing by promoting nerve and tissue regeneration.

research Cx43 hemichannel-mediated paracrine involves in the promotion of MSCs on skin wound healing

1 citations , December 2025 in “Stem Cell Research & Therapy”

Mesenchymal stem cells help heal wounds by using Cx43 hemichannels to improve tissue repair.