research Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study
Both ruxolitinib and tofacitinib are effective and safe for treating severe alopecia areata, but relapses are common.
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research Emerging nonmetabolic functions of skin fat
Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
research Toll-Like Receptor Function in Acute Wounds
Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.
research Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine
Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.
research Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation
Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.
research Immune deficiency–related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency
A deficiency in the TTC7A gene causes immune problems, gut issues, and hair loss.
research Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor β2 Expression
Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.
research ‘Hirsutism’: A Psychological Analysis
Women with excess body hair feel psychological distress influenced by societal beauty standards, but distress isn't directly linked to the amount of hair.
research Tinea genitalis: a new entity of sexually transmitted infection? Case series and review of the literature
Sexual activity can spread T. interdigitale, needing quick antifungal treatment to avoid permanent scarring.
research Localisation of members of the notch system and the differentiation of vibrissa hair follicles: Receptors, ligands, and fringe modulators
Notch-related genes play a key role in the development and cycling of hair follicles.
research External light activates hair follicle stem cells through eyes via an ipRGC–SCN–sympathetic neural pathway
Light can turn on hair growth cells through a nerve path starting in the eyes.
research HRT for women with premature ovarian insufficiency: a comprehensive review
The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.
research Hair follicle stem cell cultures reveal self‐organizing plasticity of stem cells and their progeny
The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.
research Comparison of cutaneous manifestations in chronic kidney disease with or without dialysis
Most patients with chronic kidney disease have skin problems, which get worse as the disease progresses, and dialysis doesn't greatly reduce these issues.
research Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures
The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.
research Role of -catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer
Beta-catenin is crucial for skin cell growth, development, and cancer formation.
research Relationship of the metabolic syndrome and obesity to polycystic ovary syndrome: A controlled, population-based study
Metabolic syndrome and PCOS are related but separate conditions, with metabolic syndrome increasing the risk of heart disease and diabetes.
research Physiological Regeneration of Skin Appendages and Implications for Regenerative Medicine
The document concludes that understanding hair and feather regeneration can help develop new regenerative medicine strategies.
research Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation
Applying a specific inhibitor lightens skin and hair color.
research Potential targets in the discovery of new hair growth promoters for androgenic alopecia
The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
research Application of multiphoton microscopy in dermatological studies: A mini-review
Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.
research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate
The extracellular matrix is crucial for controlling skin stem cell behavior and health.
research Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering
Improving the environment and cell interactions is key for creating human hair in the lab.
research Established risk factors for coronary heart disease are unrelated to androgen-induced baldness in female-to-male transsexuals
Baldness caused by male hormones in female-to-male transsexuals doesn't increase the risk of heart disease.
research Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells
Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
research TGFβ and cancer metastasis: an inflammation link
TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.
research Male androgenetic alopecia
DHT, a testosterone byproduct, causes male pattern baldness.
research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16
K16 can partially replace K14 but causes hair loss and skin issues.
research Dermatologic Manifestations of Human Immunodeficiency Virus Infection
HIV can cause unusual and severe skin problems that are hard to treat.
research Androgen Profiling by Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) in Healthy Normal-Weight Ovulatory and Anovulatory Late Adolescent and Young Women
The research found that anovulatory young women have higher androgen and hormone levels than those who ovulate, suggesting immature hormonal regulation rather than a specific condition.