research Concise Review: Translating Regenerative Biology into Clinically Relevant Therapies: Are We on the Right Path?
We need to understand more about regeneration to improve human tissue healing.
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research Ficoll density gradient sedimentation isolation of pelage hair follicle mesenchymal stem cells from adult mouse back skin: a novel method for hair follicle mesenchymal stem cells isolation
A new method quickly and efficiently isolates hair follicle stem cells from adult mice, promoting hair growth.
research Biofabrication Technologies in Hair Neoformation
New biofabrication technologies could lead to treatments for hair loss.
research A family business: stem cell progeny join the niche to regulate homeostasis
Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.
research Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation
Gata6 is important for protecting hair growth cells from DNA damage and keeping normal hair growth.
research Stem cell factor/c-Kit signalling in normal and androgenetic alopecia hair follicles
SCF and c-Kit decrease in AGA hair follicles, possibly affecting hair pigmentation and growth.
research What does the concept of the stem cell niche really mean today?
Stem cell niches support, regulate, and coordinate stem cell functions.
research Epidermal stem cell fate: what can we learn from embryonic stem cells?
Embryonic and adult stem cells are valuable for improving skin grafts and cell therapy.
research Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia
Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.
research 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression
The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.
research Mapping cell dynamics in human ex vivo hair follicles suggests pulling mechanism of hair growth
Hair growth may involve a pulling force from the outer root sheath.
research Fibroblast heterogeneity and functions: insights from single-cell sequencing in wound healing, breast cancer, ovarian cancer and melanoma
Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.
research Signaling in the stem cell niche: regulating cell fate, function and plasticity
The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.
research Skin Cell Heterogeneity in Development, Wound Healing, and Cancer
Different types of skin cells play specific roles in development, healing, and cancer.
research 25 Years of Epidermal Stem Cell Research
Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.
research Diversity of Adult Stem Cell Niches in the Dermal Compartment of Skin
The skin's dermal layer contains true stem cells with diverse functions and interactions that need more research to fully understand.
research 606 Connecting signaling dynamics with cell fates in live mice
Stem cells control their future role by changing ERK signal timing, affecting tissue regeneration and cancer.
research Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies
New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
research Single-cell chromatin landscapes of mouse skin development
The study maps how genes are regulated during mouse hair growth.
research Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche
Different types of stem cells and their environments are key to skin repair and maintenance.
research The Harmonies Played by TGF-β in Stem Cell Biology
TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.
research Hair follicle stem cell cultures reveal self‐organizing plasticity of stem cells and their progeny
The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.
research Regulation of melanocyte stem cell behavior by the niche microenvironment
The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.
research Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons
Understanding hair follicle biology and stem cell control could lead to new hair loss treatments.
research Stem Cell Competition for Niche Occupancy: Emerging Themes and Mechanisms
Stem cells compete for space using cell adhesion, and mutations can affect their competitive success, with implications for tissue health and disease.
research Isolation and Characterization of a Fetal-Maternal Microchimeric Stem Cell Population in Maternal Hair Follicles Long after Parturition
Fetal-maternal stem cells in a mother's hair can help with tissue repair and regeneration long after childbirth.
research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche
The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.
research Understanding the molecular basis of mesenchymal stem cell stemness: implications for clinical applications
Understanding how mesenchymal stem cells stay undifferentiated can improve their use in treating diseases.
research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1
Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.
research T cell and bacterial microbiota interaction at intestinal and skin epithelial interfaces
T cells and bacteria in the gut and skin help maintain health and protect against disease.