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Did you mean Matrix Metalloproteinase-1?

GlossaryMatrix Metalloproteinase-1

enzyme that breaks down collagen in connective tissues

Matrix Metalloproteinase-1 (MMP-1), also known as interstitial collagenase, is an enzyme that breaks down collagen, a key structural protein in the skin and other connective tissues. This process is crucial for normal tissue remodeling and repair, but excessive MMP-1 activity can contribute to conditions like skin aging and certain diseases by degrading too much collagen.

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research A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women

8 citations , May 2005 in “Fertility and Sterility”

A specific gene variation is linked to a higher risk of polycystic ovary syndrome in Caucasian women.

research In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition

7 citations , May 2022 in “Indonesian Journal of Science and Technology”

Compounds from Etlingera alba may help treat Triple Negative Breast Cancer.

research Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle

21 citations , May 2016 in “Experimental and Therapeutic Medicine”

MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

research Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

3 citations , July 2020 in “Frontiers in Cell and Developmental Biology”

Vitexin Compound 1 may help reduce skin aging caused by UVA light.

research Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice

December 2025 in “International Journal of Molecular Sciences”

Centella asiatica extract taken orally can reduce skin aging from UVB exposure.

research Expression Profiling and Cellular Localization of Genes Associated with the Hair Cycle Induced by Wax Depilation

27 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers found new genes involved in hair growth, which could help develop new hair treatments.

research Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation

40 citations , February 2020 in “Experimental and Therapeutic Medicine”

PRP injections improve facial skin by reducing wrinkles and pores.

research Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging

14 citations , December 2020 in “Journal of Investigative Dermatology”

Aging causes changes in the scalp that can affect hair growth and lead to older-looking hair in women.

research Anti-aging effect of Grateloupia elata extract in skin

September 2025 in “Journal of Applied Biological Chemistry”

Grateloupia elata extract may be effective for anti-aging skincare.

research Scarless wound healing: Transitioning from fetal research to regenerative healing

79 citations , January 2018 in “Wiley Interdisciplinary Reviews-Developmental Biology”

Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.

research Antioxidant Capacity and Protective Effect of Cow Placenta Extract on D-Galactose-Induced Skin Aging in Mice

4 citations , November 2022 in “Nutrients”

Cow placenta extract has strong antioxidant effects and can delay skin aging in mice.

research Radiofrequency Currents Modulate Inflammatory Processes in Keratinocytes

3 citations , October 2024 in “International Journal of Molecular Sciences”

CRET therapy affects inflammation in skin cells by changing cytokine levels and activating certain proteins.

research Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia

September 2023 in “Medicine”

The research suggests immune system changes and specific gene expression may contribute to male hair loss, proposing potential new treatments.

iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

research iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

19 citations , December 2016 in “PLOS ONE”

Early-stage skin cells help regenerate hair follicles, with proteins SDF1, MMP3, biglycan, and LTBP1 playing key roles.

research In Vivo Evaluation ofEclipta albaExtract as Anticancer and Multidrug Resistance Reversal Agent

9 citations , June 2014 in “Nutrition and Cancer”

Eclipta alba extract may work as an anticancer agent and help reverse drug resistance.

research Matrisomal components involved in regenerative wound healing in axolotl and Acomys: implications for biomaterial development

January 2023 in “Biomaterials Science”

Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.

research Desmodesmus pannonicus Water Extract Inhibits Melanin Synthesis and Promotes Wound Healing

1 citations , November 2024 in “Life”

Desmodesmus pannonicus water extract may help reduce skin pigmentation, heal wounds, and promote hair growth.

research Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2

22 citations , June 2018 in “Journal of Neuroinflammation”

Procyanidins from grape seeds reduce nerve pain by blocking specific proteins and inflammation.

research Wound Healing: A Cellular Perspective

1160 citations , November 2018 in “Physiological Reviews”

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

research Comparison of two ASC-derived therapeutics in an in vitro OA model: secretome versus extracellular vesicles

60 citations , December 2020 in “Stem Cell Research & Therapy”

ASC-CM is more effective than EV for treating osteoarthritis.

Identifying Key Components and Therapeutic Targets of the Immune System in Hidradenitis Suppurativa with an Emphasis on Neutrophils

research Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils

16 citations , September 2020 in “British journal of dermatology/British journal of dermatology, Supplement”

The article suggests that targeting specific immune pathways could help control and treat the skin disease hidradenitis suppurativa.

research Update in minimally invasive periorbital rejuvenation with a focus on platelet‐rich plasma: A narrative review

15 citations , March 2020 in “Journal of cosmetic dermatology”

PRP is effective for improving the appearance around the eyes.

Col4a2-eGFP Mouse Model Reveals the Molecular and Functional Dynamics of Basement Membrane Remodelling in Hair Follicle Morphogenesis

research Col4a2-eGFPmouse model reveals the molecular and functional dynamics of basement membrane remodelling in hair follicle morphogenesis

November 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Scientists made a mouse that shows how a specific protein in the skin changes and affects hair growth and shape.

research The effects of infrared radiation on the human skin

July 2023 in “Photodermatology, Photoimmunology and Photomedicine”

Infrared radiation can cause skin aging and cancer at high temperatures but may have therapeutic benefits at controlled levels.

research Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells

92 citations , August 2017 in “Proceedings of the National Academy of Sciences of the United States of America”

Newborn mouse skin cells can grow hair and this process can be recreated in adult cells to potentially help with hair loss.

research Investigation of the molecular alterations associated with the efficacy of microneedling therapy and its potential applications in medical and dental practices

1 citations , December 2024 in “Pomeranian Journal of Life Sciences”

Microneedling helps heal and rejuvenate skin and gums effectively.

research An in silico approach to the identification of potential proteomic and genomic diagnostic biomarkers for primary cicatricial alopecia

October 2021 in “Experimental Dermatology”

Certain genes and proteins may help diagnose and treat primary cicatricial alopecia.

research Effects of natural products on skin inflammation caused by abnormal hormones secreted by the adrenal gland

2 citations , May 2023 in “Frontiers in Pharmacology”

Natural products may help treat skin inflammation from abnormal adrenal hormones.

research Referee report. For: Molecular mediators involved in skin healing: a narrative review [version 1; peer review: 1 approved with reservations]

January 2022 in “Faculty of 1000 Research Ltd”

Understanding molecular mediators can improve skin healing treatments.

research Identification of clustered cells in human hair follicle responsible for MMP‐9 gelatinolytic activity: consequences for the regulation of hair growth

27 citations , June 2001 in “International Journal of Dermatology”

MMP-9 increase in hair follicles may lead to hair loss.