research A multi-omic single-cell landscape of perinatal mouse skin maps lineage specification and reveals shared dynamics in human fetal skin
Mouse and human skin development share similar fibroblast timelines.
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research Isoproterenol directs hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tissue sheets
Isoproterenol helps hair follicle stem cells turn into beating heart muscle cells.
research Lineage Commitment of Dermal Fibroblast Progenitors is Mediated by Chromatin De-repression
Skin cell types develop when specific genes are turned on by removing certain chemical tags from DNA.
research Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.
research Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state
Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
research Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells
Marine-derived saccharides may help reduce aging effects on skin and hair by promoting cell growth and collagen production.
research Dermal fibroblast in cutaneous development and healing
Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.
research Fibroblasts: Origins, definitions, and functions in health and disease
Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
research Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype
Aging reduces dermal sheath cells, affecting youthful skin appearance.
research A Niche Above: A Novel Modality of Stem Cell Regulation in Mammalian Skin Epidermis
Skin cell behavior is influenced by the tightness of nearby cells, affecting their growth and development.
research From hair to heart: nestin-expressing hair-follicle-associated pluripotent (HAP) stem cells differentiate to beating cardiac muscle cells
Hair follicle stem cells can become heart muscle cells.
research Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery
New drugs for heart disease may be developed from molecules secreted by stem cells.
research ATP-dependent chromatin remodeling during mammalian development
ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.
research Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia
Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.
research The Pharmacology of Regenerative Medicine
Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.
research Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia
New genes found linked to balding, may help develop future treatments.
research Abstracts from the 55th European Society of Human Genetics (ESHG) Conference: Oral Presentations
NIPT can help detect potential maternal cancer, and GIPXplore can identify immune diseases in pregnancies.
research Tissue homeostasis
Humans have limited regenerative abilities, but new evidence shows the adult brain and heart can regenerate, and future treatments may improve this by mimicking stem cell environments.
research A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis
Immune cells are essential for early hair and skin development and healing.
research In vivoreprogramming of wound-resident cells generates skin with hair
Scientists can now create skin with hair by reprogramming cells in wounds.
research Calcium regulation of stem cells
Calcium is important for stem cell function and maintenance, especially in blood and skin cells.
research Experimental and early investigational drugs for androgenetic alopecia
New hair loss treatments may include topical medications, injections, and improved transplant methods.
research Characterisation of Myotonic Dystrophy type I cell models and drug evaluation by a cell- based quantification platform.
Antisense oligonucleotides show promise for treating Myotonic Dystrophy type I.
research Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model
IGF2BP3 gene is up-regulated in keloid patients, suggesting potential targets for treatment.
research Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity
The study concluded that specific proteins are necessary to maintain the structure that holds epithelial cells tightly together.
research Induction of cardiomyocyte‑like cells from hair follicle cells in mice
Mouse hair follicle cells can become heart-like cells without genetic changes.
research Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices
Different small areas within hair follicles send specific signals that control what type of cells stem cells become.
research Mesenchymal Stem Cells for Regenerative Medicine
Mesenchymal stem cells can help repair body tissues with low risk of rejection.
research Pleiotropic Role of Notch Signaling in Human Skin Diseases
Notch signaling disruptions can cause various skin diseases.
research Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth
Isoxazole 9 (ISX9) may help regrow hair by activating certain cell signals.