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From Pathophysiology to Potential Interventions: Investigating the Intricate Dynamics of Polycystic Ovary Syndrome, Aging, and Fertility

research FROM PATHOPHYSIOLOGY TO POTENTIAL INTERVENTIONS: INVESTIGATING THE INTRICATE DYNAMICS OF POLYCYSTIC OVARY SYNDROME, AGING, AND FERTILITY

December 2023 in “Anti-Aging Eastern Europe”

PCOS, aging, and fertility are linked by hormonal and metabolic issues, with lifestyle changes and treatments offering potential help.

research Chitosan stimulates root hair callose deposition and inhibits root hair growth

July 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Chitosan slows root hair growth and causes a buildup of callose at low concentrations, but at high concentrations, it only inhibits growth without callose buildup.

research Effect of Testosterone, Dihydrotestosterone, Estradiol and Cortisol on the Quality of Fresh and Cryopreserved Stallion Sperm

June 2022 in “Journal of Experimental Biology and Agricultural Sciences”

Higher testosterone harms sperm motility, while higher estradiol improves sperm survival.

Differential Expression of Proteins in Tibetan Sheep Ovaries and Their Relationship with Sub-Dimensional Characteristics at Different Follicular Development Stages

research Tibet Koyun Ovaryumunda Proteinlerin Farklı Ekspresyonu ve Farklı Foliküler Gelişim Aşamalarında Alt Boyut Özellikleriyle İlişkisi

January 2022 in “Kafkas Universitesi Veteriner Fakultesi Dergisi”

The research improved understanding of twin births and fertility in Tibetan sheep, helping animal farming.

research Abstracts from the ASA 40thAnnual Meeting

April 2015 in “Andrology”

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

Higher Androgen and Estrogen Output and Less Follicular Atresia Can Be Induced in Healthy Ovaries by Culturing Them with Sera from PCOS Patients: Is PCOS Really of Intraovarian Origin?

research Higher androgen and estrogen output and less follicular atresia can be induced in healthy ovaries by culturing them with sera from PCOS patients: is PCOS really of intraovarian origin?

August 2013 in “Fertility and Sterility”

PCOS may be influenced by factors in the blood, not just the ovaries.

Modeling Androgen Synthesis and Action During Human Sexual Differentiation

research Modelling androgen synthesis and action during human sexual differentiation

February 2010 in “ePrints Soton (University of Southampton)”

Male sexual differentiation is regulated independently, while female differentiation occurs in an androgenic environment, affecting conditions like congenital adrenal hyperplasia.

research The Effect of Finasteride on the Secretion of Testosterone, DHT, LH, FSH and Tissue Factors in the Testis of NMRI Mice:

June 2021 in “Archives of Advances in Biosciences”

Finasteride reduces sperm count and quality and alters hormone levels in mice.

research Effects of anticonvulsant drugs on chromosomes.

19 citations , October 1971 in “The BMJ”

Anticonvulsant drugs may cause temporary chromosomal abnormalities.

research Abstract 3889: Cyclin-dependent kinase 4 levels affect the number of hair follicle stem cells in mouse epidermis

April 2010 in “Cancer Research”

CDK4 levels affect the number of hair follicle stem cells in mice.

research Analysis of genome DNA methylation at inherited coat-color dilutions of Rex Rabbits

1 citations , January 2020 in “Research Square (Research Square)”

Inherited color dilution in Rex rabbits is linked to DNA methylation changes in hair follicles.

research Nongenotoxicity of minoxidil in murine hair follicles as determined by the nuclear aberration assay

12 citations , January 1988 in “Toxicology and Applied Pharmacology”

Minoxidil promotes hair growth without causing DNA damage.

Aberrant Connective Tissue Sheath Contraction Drives Premature Hair Follicle Regression by Inducing Progenitor Cell Depletion in Androgenetic Alopecia

research Aberrant connective tissue sheath contraction drives premature hair follicle regression by inducing progenitor cell depletion in androgenetic alopecia

December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Abnormal contraction of connective tissue in hair follicles causes hair loss by killing off important cells, and treating this could improve hair growth.

research Atrichia with papular lesions in two Pakistani consanguineous families resulting from mutations in the human hairless gene

20 citations , October 2005 in “Archives of Dermatological Research”

research Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles.

35 citations , April 1998 in “PubMed”

Activated erbB-2 in mice skin causes severe skin and hair abnormalities.

research A Homozygous Frameshift Mutation in theHOXC13Gene Underlies Pure Hair and Nail Ectodermal Dysplasia in a Syrian Family

30 citations , January 2013 in “Human Mutation”

A mutation in the HOXC13 gene causes hair and nail problems in a Syrian family.

Maternal Androgen Excess Inhibits Fetal Cardiomyocyte Proliferation Through RB-Mediated Cell Cycle Arrest and Induces Cardiac Hypertrophy in Adulthood

research Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood

2 citations , August 2023 in “Journal of Endocrinological Investigation”

Excess maternal androgens can cause heart problems in offspring.

research [Association of eight single nucleotide polymorphisms of chromosomes 20 and X with androgenetic alopecia among ethnic Han Chinese from Yunnan].

June 2016 in “PubMed”

Certain genetic markers on chromosome 20 are linked to hair loss in the Han Chinese from Yunnan.

Cyclical Dermal Micro-Niche Switching Governs the Morphological Infradian Rhythm of Mouse Zigzag Hair

research Alterations in Corneal Sensitivity, Staining and Biomechanics of Alopecia Areata Patients: Novel Findings in a Case-Control Study

1 citations , April 2024 in “Journal of Clinical Medicine”

Alopecia areata patients have eye issues and need regular eye exams.

research RETRACTION: Causal Effects of Omega‐6 and LDL‐C on Androgenetic Alopecia: A Mendelian Randomization Study

June 2025 in “Skin Research and Technology”

research A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix

100 citations , November 1997 in “Human Genetics”

A new mutation in the hHb1 keratin gene is linked to the hair disorder monilethrix.

research Monilethrix: A Novel Mutation (Glu402Lys) in the Helix Termination Motif and the First Causative Mutation (Asn114Asp) in the Helix Initiation Motif of the Type II Hair Keratin hHb6

29 citations , August 1999 in “Journal of Investigative Dermatology”

New mutations in hair keratin genes cause the rare hair disorder monilethrix.