27 citations
,
October 1945 in “Endocrinology” Synthetic hormone treatment reduces melanin and hair growth in rats.
26 citations
,
July 2007 in “Biochemical Pharmacology” ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.
25 citations
,
June 2015 in “Clinical, Cosmetic and Investigational Dermatology” Microneedling helps increase the absorption of a melanin product into hair follicles, which may improve laser hair removal effectiveness.
18 citations
,
March 2015 in “Journal of Investigative Dermatology” Silencing certain circadian clock genes increases skin pigmentation.
14 citations
,
May 2022 in “Animals” Female goslings have darker feathers than males due to more melanin.
14 citations
,
September 2017 in “General and comparative endocrinology” Barn owls with smaller black spots have higher testosterone levels, which might be due to genetic effects on hormone regulation rather than hormone effects on coloration.
12 citations
,
November 2020 in “Molecules” Carvone helps treat skin issues by reducing melanin and stopping harmful cell growth.
10 citations
,
June 2009 in “Acta Biochimica Polonica” Old C57BL/6 mice with unsynchronized hair cycles show less melanin in their spleens.
7 citations
,
September 2021 in “Journal of Applied Polymer Science” Cuttlefish ink melanin protects hair from UV damage.
7 citations
,
November 2011 in “Skin Research and Technology” The study found a specific pattern of uneven melanin distribution on balding scalps that could help understand skin diseases caused by light exposure.
6 citations
,
September 2022 in “Frontiers in pharmacology” Epimedium extract helps increase skin pigmentation and could be a new treatment for conditions with reduced pigmentation.
4 citations
,
March 2013 in “The American Journal of Cosmetic Surgery” Melanin absorbing light is necessary but not enough for effective hair removal by light treatment.
1 citations
,
November 2024 in “Life” Desmodesmus pannonicus water extract may help reduce skin pigmentation, heal wounds, and promote hair growth.
1 citations
,
January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” Increased PHGDH expression causes early melanin buildup in hair follicles.
1 citations
,
May 2017 in “Journal of cosmetic and laser therapy” Lasers can help reduce skin side effects from cancer treatment.
December 2025 in “Journal of Advanced Biotechnology and Experimental Therapeutics” Mesenchymal stem cells may help reduce melanin in UV-exposed mice.
September 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” Non-invasive methods can effectively monitor hair growth cycles, aiding hair loss treatment development.
April 2024 in “International journal of molecular sciences” Dermal factors are crucial in regulating melanin production in skin.
January 2024 in “International Journal of Herbal Medicine” Melanin is important for hair color, health, and UV protection.
August 2023 in “International Journal of Molecular Sciences” The human scalp hair bulb contains different types of melanocytes with varying abilities to produce melanin.
January 2019 in “DSpace@MIT (Massachusetts Institute of Technology)” Higher PHGDH levels cause unusual melanin buildup in hair follicles.
January 2017 in “Archives of clinical and biomedical research” Enhancing melanin's energy generation may help treat alopecia areata.
Melanin-rich skin has unique challenges in diagnosing and treating skin diseases.
PMEE may help reverse greying hair by boosting melanin production.
35 citations
,
January 1981
19 citations
,
November 2023 in “npj Regenerative Medicine” Synthetic melanin applied to skin speeds up wound healing.
July 2024 in “Journal of Cosmetic Dermatology” Hydrophilic melanin may help hair grow by improving blood flow and regeneration.
January 2016 in “UNESP Institutional Repository (São Paulo State University)” Melasma results from changes in the skin's pigment and structure, not just pigment cell growth.
140 citations
,
August 2010 in “Pigment Cell & Melanoma Research” We know a lot about mouse hair color, but not much about human hair color differences.
6 citations
,
September 2010 in “Pigment Cell & Melanoma Research” We know less about human hair pigmentation than mouse coat color, but pH and cysteine levels are key factors.