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PRAME helps distinguish between benign and malignant skin cells in most cases.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

Hair-follicle stem cells can become neurons.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Human hair follicles can provide stem cells for regenerative medicine.

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.

We need more research on human hair follicle pigmentation, not just mouse models.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

3D skin models better mimic human skin and melanoma progression than older methods.

Alopecia areata is caused by immune system attacks on hair follicles, often triggered by viral infections.

Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.

PSENEN gene mutations can cause both Dowling-Degos disease and acne inversa.

Stem cells in hair follicles are diverse and change throughout the hair cycle.

Certain genes control the color of human hair by affecting pigment production.

Minoxidil and Finasteride are effective for male baldness; more research is needed for hair aging treatments.

New vitiligo treatments focus on controlling immune damage and restoring skin color.

Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.

Hair grays due to oxidative stress and fewer functioning melanocytes.

Mutations in TBX3 cause horses to have more even hair color instead of Dun camouflage.

Hair color loss can indicate the effectiveness of a drug targeting the KIT protein in mice and humans.

Vitiligo and alopecia areata may have similar causes despite their differences.

Notch/RBP-J signaling is crucial for proper placement and timing of melanocyte development in hair follicles.

Advanced human skin models improve drug development and could replace animal testing.

The pituitary gland controls seasonal fur color changes in weasels.

Hair greying is caused by oxidative stress damaging hair follicles and melanocytes.

The Skin POMC System affects hair growth and skin responses to stress.