97 citations
,
September 2016 in “Reviews in Endocrine and Metabolic Disorders” The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.
68 citations
,
June 2005 in “Expert Opinion on Therapeutic Targets” Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.
36 citations
,
August 2011 in “Journal of Controlled Release” Genetically-altered adult stem cells can help in wound healing and are becoming crucial in regenerative medicine and drug design.
3 citations
,
November 2018 in “Curēus” The cause and importance of misplaced oil glands in the hair follicle are not well understood.
159 citations
,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
148 citations
,
December 2018 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
132 citations
,
January 2017 in “International Journal of Molecular Sciences” Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.
130 citations
,
August 2015 in “Experimental Dermatology” Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.
106 citations
,
June 2005 in “Journal of Investigative Dermatology” The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.
71 citations
,
February 2006 in “Clinics in Dermatology” Pregnancy causes skin changes like darkening, hair thickening, nail changes, and increased risk of skin growths, most of which usually resolve after birth.
67 citations
,
September 2003 in “Journal of cutaneous pathology” Skin problems are very common in people with end-stage kidney disease.
58 citations
,
October 2016 in “Journal of Investigative Dermatology” Activating Nrf2 protects human hair follicles from oxidative stress and helps prevent hair growth inhibition.
53 citations
,
January 2009 in “Journal of Investigative Dermatology” UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.
48 citations
,
May 2008 in “Drug Discovery Today: Disease Mechanisms” Hair follicles offer promising targets for delivering drugs to treat hair and skin conditions.
47 citations
,
January 2013 in “International Journal of Cosmetic Science” Hair diversity is influenced by complex genetics and environmental factors, requiring more research for practical solutions.
42 citations
,
April 2012 in “Seminars in Oncology” Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.
40 citations
,
May 2014 in “PLoS ONE” Chronic stress can reduce skin pigmentation.
26 citations
,
May 2014 in “BioEssays” Using neurohormones to control keratin can lead to new skin disease treatments.
24 citations
,
March 2015 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” Some skin conditions are common during pregnancy and can be safely treated without affecting the pregnancy outcome.
21 citations
,
October 2009 in “Biochemical Engineering Journal” Stem cell therapy is a promising approach for hair regrowth despite potential side effects.
11 citations
,
January 2012 in “Journal of cell science” Rac1 is essential for proper hair structure and color.
9 citations
,
December 2014 in “Neuropsychiatric Disease and Treatment” People with first-time vitiligo have lower levels of a certain brain protein compared to healthy individuals.
7 citations
,
May 2014 in “Clinical practice” Cooling the scalp may prevent hair loss from chemotherapy, hair often grows back after treatment, and nail issues usually improve after stopping the drug.
1 citations
,
January 2024 in “Annals of Dermatology” Examining hair shape can help predict Alopecia Areata's progression.
1 citations
,
April 2016 in “CRC Press eBooks” Skin aging reflects overall body aging and can indicate internal health conditions.
April 2026 in “Dermatology and Therapy” Experts agree on understanding hair aging to improve diagnosis and treatments.
March 2026 in “Plastic and Aesthetic Research” Adipose-derived stem cell exosomes can help reduce skin aging from UV exposure.
December 2025 in “Journal of Advanced Biotechnology and Experimental Therapeutics” Mesenchymal stem cells may help reduce melanin in UV-exposed mice.
November 2025 in “Nature Communications” Hair growth may involve a pulling force from the outer root sheath.
July 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences” Examining Survivin levels may help understand premature greying of hair.