The human scalp has different types of pigment cells in hair follicles with varying abilities to produce pigment.
June 2023 in “JAAD Case Reports” A man had a rare skin cancer that looked like a bald spot.
June 2025 in “Albus Scientia” MC1R gene variations affect skin, hair color, UV sensitivity, and melanoma risk.
25 citations
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March 2012 in “Journal of oncology pharmacy practice” An 81-year-old man's white hair began to regain its original color while he was treated with lenalidomide, suggesting that graying hair might be reversible.
4 citations
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May 2018 in “International Journal of Molecular Sciences” The research showed how melanocytes develop, move, and respond to UV light, and their stem cells' role in hair color and skin cancer risk.
12 citations
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November 2004 in “Photochemistry and Photobiology” Superoxide dismutase (SOD) can prevent hair graying in mice.
January 1990 in “대한피부과학회지” Peanut agglutinin staining helps differentiate malignant melanoma from nevocellular nevus.
The PI's development is closely linked to skin and hair pigmentation in macaques.
7 citations
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December 2013 in “The Journal of Dermatology” A woman's hair turned gray and fell out after starting a cancer drug called imatinib mesylate.
11 citations
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July 2008 in “International Journal of Dermatology” Greying hairs may be protected from alopecia areata.
September 2017 in “Journal of Investigative Dermatology Symposium Proceedings” Non-melanoma skin cancer in darker-skinned people can be misdiagnosed, so doctors need to be more aware to diagnose it correctly and early.
Acitretin treatment unexpectedly darkened a patient's gray hair.
14 citations
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October 2017 in “Gene Expression Patterns” A new mouse model helps study melanocyte cells using GFP expression.
66 citations
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December 2014 in “Nature Communications” Fibroblasts can be turned into melanocytes for potential skin treatments.
Human hair color is determined by melanin types and genetic factors.
April 2023 in “Australasian Journal of Dermatology” Lentiginous melanoma is most common on the face, especially the nose, cheek, and pre-auricular areas, with men more likely to have it on the scalp, ears, upper back, and trapezius, and women on the cheek and anterior arm. Sun damage is a key factor in its formation.
7 citations
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July 2020 in “Pigment cell & melanoma research” RT1640 treatment reverses gray hair and promotes hair growth in mice.
10 citations
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August 2023 in “Animals” SLC45A2 and GPNMB genes help control chicken feather color by promoting melanin.
60 citations
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August 2005 in “Endocrinology” αMSH may help regulate immune responses in hair follicles and its disruption could lead to hair loss.
36 citations
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June 2016 in “Journal of dermatological treatment” The combination therapy significantly improved Riehl’s melanosis in patients without serious side effects.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Researchers found three types of melanocytes in developing mouse skin, each with different genes and locations.
January 2023 in “Springer eBooks”
June 2017 in “Journal of The American Academy of Dermatology” The new treatment was safe and may effectively treat male pattern hair loss.
April 2015 in “한국생물공학회 학술대회” Finasteride reduces melanin production in skin cells.
August 2025 in “Annals of Medicine” Mycophenolate mofetil may safely help restore skin color in depigmentation conditions.
January 2025 in “Cellular and Molecular Life Sciences” BMP4 helps stem cells turn into pigment-producing cells, affecting hair color and growth.
1 citations
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December 2018 in “IOP conference series. Materials science and engineering” CD34+ hair follicle stem cells can become melanin-producing cells for treating skin conditions.
12 citations
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December 1981 in “Journal of Endocrinology” α-MSH increases melanin production in moulting hair follicles, while AVT inhibits it.
April 2024 in “The Indonesian Biomedical Journal” Melanocyte stem cells from non-affected skin in vitiligo patients can become functional melanocytes for potential therapy.
7 citations
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July 2013 in “Acta Biochimica Polonica” Chemotherapy reduces splenic melanin in mice.