July 2025 in “Advanced Science” Collagen VI and Semaphorin 3C are important for hair pigmentation and could help treat pigmentation disorders.
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April 1979 in “Journal of Ultrastructure Research” 62 citations
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December 1966 in “Endocrinology” Injecting α-MSH made mice's hair turn black.
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June 2025 in “Journal of Cellular and Molecular Medicine” Plant-derived compounds may help reverse grey hair by boosting melanin production.
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November 2015 in “PloS one” Reducing Tyrosinase prevents mature color pigment cells from forming in mouse hair.
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February 2022 in “Journal of pineal research” Melatonin affects skin and hair color and protects skin cells, with potential benefits for hair growth and skin health.
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January 2023 in “Cancer Research” AMPK activation may reduce melanoma risk in red-haired individuals.
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January 2002 Melanin and melanocytes contribute to the brown pigmentation in stasis dermatitis.
January 2019 in “DSpace@MIT (Massachusetts Institute of Technology)” Higher PHGDH levels cause unusual melanin buildup in hair follicles.
August 2023 in “Journal of Investigative Dermatology” 50 citations
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February 2004 in “Journal of Investigative Dermatology”
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July 2007 in “Biochemical Pharmacology” ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.
November 2021 in “CRC Press eBooks” Hair color is determined by melanin and can be affected by genetic conditions like albinism.
Hair turning darker can be a sign of skin cancer.
February 2026 in “Case Reports in Dermatology” Finasteride can cause melasma, especially in people with darker skin.
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June 2005 in “Acta Biochimica Polonica” Splenic eumelanin in C57BL/6 mice is different from hair eumelanin.
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October 1945 in “Endocrinology” Synthetic hormone treatment reduces melanin and hair growth in rats.
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November 2020 in “Molecules” Carvone helps treat skin issues by reducing melanin and stopping harmful cell growth.
January 2026 in “Figshare” Finasteride can cause melasma, especially in people with darker skin.
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January 1992 in “Experientia” 29 citations
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January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.
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September 2024 in “Animals” Key genes influence melanin in chicken muscles, affecting their value.
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February 1994 in “Experimental dermatology” Melatonin affects mouse skin and may regulate skin functions.
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January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Applying a specific inhibitor lightens skin and hair color.
January 2026 in “Figshare” Finasteride can cause melasma, especially in people with darker skin.
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November 2022 in “Frontiers in Oncology” Melanin may help melanoma cells grow by aiding their metabolism.
May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” Nicastrin deficiency may cause skin cell damage and pigmentation disorders in humans, similar to effects seen in fish.
January 2004 in “Linchuang pifuke zazhi” All-trans retinoic acid helps amelanotic melanocytes in hair follicles develop and produce pigment while reducing their growth.
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April 2013 in “SpringerPlus” Human skin's melanocytes respond to light by changing shape, producing pigments and hormones, which may affect sleep patterns.
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January 2014 in “Elsevier eBooks” Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.