November 2022 in “Journal of Investigative Dermatology” Blocking mTORC1 activity could increase hair pigmentation and potentially reverse greying.
July 2025 in “Pigment International” Follicular vitiligo causes hair to gray without skin color loss.
Acitretin treatment unexpectedly darkened a patient's gray hair.
63 citations
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February 2017 in “ACS biomaterials science & engineering” Polydopamine is a safe, effective, and permanent hair dye that turns gray hair black in one hour.
14 citations
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January 1984 in “Nutrition reports international”
April 2023 in “Journal of Investigative Dermatology” Blocking casein kinase 1 in skin cells can help melanocyte precursors move better, potentially helping with conditions like vitiligo or gray hair.
62 citations
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December 1941 in “Experimental biology and medicine” Eating phenylthiocarbamide made all the rats' hair go gray, but some returned to their original color after stopping.
June 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” A new hair dye method uses polyphenols and oxidation to create a long-lasting brown color on gray hair.
2 citations
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November 2024 in “JAAD reviews.” Certain drugs can change hair color, either lightening or darkening it.
14 citations
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January 2018 in “Skin Appendage Disorders” Upper eyelid hyperpigmentation can help diagnose facial lichen planus pigmentosus in patients with frontal fibrosing alopecia.
5 citations
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January 2018 in “Indian Dermatology Online Journal” A brown shadow seen in dermoscopy is a marker for lichen nitidus.
January 2010 in “Pharmacy Today” Collagen reduces skin melanin, boosts antioxidants, and improves skin moisture.
2 citations
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June 2009 in “Journal of the American Academy of Dermatology” The treatment didn't work for the woman's hair loss and skin darkening.
1 citations
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January 2013 in “Nasza Dermatologia Online” Vitamin B12 deficiency can cause reversible hair color loss in children.
January 2016 in “Xumu Shouyi Xuebao”
18 citations
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September 2016 in “International Journal of Molecular Sciences” Polydeoxyribonucleotide (PDRN) may help lighten skin and treat hyperpigmentation.
21 citations
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November 2011 in “Veterinary Pathology” Mouse skin color ranges from pink to black, depending on their hair growth cycle.
9 citations
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July 2010 in “British Journal of Dermatology” The document suggests a rare skin condition might be caused by a genetic phenomenon.
31 citations
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February 1999 in “Dermatologic surgery” Sun exposure after laser hair removal can cause skin darkening, which is hard to treat and requires avoiding UV light.
1 citations
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January 2012 in “Human health handbooks” Hair color is determined by melanin types and gene activity.
8 citations
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June 2009 in “British Journal of Dermatology” Human melanocytes in skin and hair follicles don't express keratin 16 or 6 naturally.
16 citations
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September 1999 in “Journal of Investigative Dermatology Symposium Proceedings”
January 2025 in “International Journal of Dermatology” Consider TFI in facial hypopigmentation diagnoses and confirm with a biopsy.
144 citations
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December 2017 in “Pigment cell & melanoma research” Melasma is now considered a skin aging disorder caused by sun exposure in people with a genetic tendency, which impacts treatment and prevention approaches.
6 citations
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February 2014 in “Human & experimental toxicology” Testosterone injections can cause skin darkening and thickening.
82 citations
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November 1985 in “Archives of Dermatology” The newborn's skin condition improved over time, leaving only lighter skin patches.
July 2021 in “PARIPEX INDIAN JOURNAL OF RESEARCH” Knuckle darkening can be an early sign of vitamin B12 deficiency.
15 citations
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January 2013 in “Dermatologic Surgery” Epithelial grafting can effectively repigment white hair in vitiligo patients.
March 2024 in “Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān/Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān./Zahedan journal of researches in medical sciences” Microneedling with PRP effectively reduces facial pigmentation with minimal side effects.
1 citations
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August 1998 in “Pediatrics in review” Understanding cultural practices and skin reactions is crucial for diagnosing and treating skin conditions in children with dark skin.