New treatments for hair loss should target eight main causes and use specific plant compounds and peptides for better results.
4 citations
,
January 2025 in “Pharmaceutics” The gel is a safe and effective treatment for hyperpigmentation.
April 2026 in “IntechOpen eBooks” Burn injuries can cause long-term itching, skin color changes, and cancer risks, needing personalized treatment.
January 2026 in “Clinical Journal for Nurse Practitioners in Women s Health” Pregnancy can cause skin changes, some harmless and others risky, needing careful management.
October 2025 in “Nature Reviews Disease Primers”
October 2025 in “Pharmaceutics” Microneedles improve drug delivery for skin diseases, enhancing treatment effectiveness and patient compliance.
May 2023 in “Frontiers in Endocrinology” Thyroid disease can cause skin, hair, and nail problems, and treating the thyroid condition often improves these symptoms.
506 citations
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January 2012 in “Molecular and Cellular Endocrinology” Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.
252 citations
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January 2008 in “Trends in Endocrinology and Metabolism” Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.
222 citations
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January 2005 in “Endocrine journal” Melatonin is important for skin health and protection, and can be made by the skin or applied to it.
220 citations
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August 1988 in “Clinical endocrinology” Melatonin may help with sleep issues, depression, and cancer, but more research is needed.
185 citations
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February 2018 in “Journal of Investigative Dermatology” Melatonin may benefit skin health and could be a promising treatment in dermatology.
160 citations
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April 2014 in “Drug discovery today” Melatonin helps regulate sleep and may aid in treating various health issues.
160 citations
,
July 2008 in “Experimental dermatology” Melatonin protects the skin by scavenging free radicals and repairing DNA damage.
133 citations
,
August 1969 in “Science” Melatonin causes weasels to grow white fur and become reproductively inactive.
122 citations
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July 2005 in “The FASEB journal” Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.
109 citations
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October 2007 in “Journal of pineal research” Melatonin helps regulate hair growth and protects the hair follicle from stress.
81 citations
,
May 2019 in “Frontiers in Endocrinology” Melatonin may improve some hormonal and inflammatory issues in women with PCOS.
78 citations
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February 2004 in “British Journal of Dermatology” Melatonin helps hair growth in women with hair loss.
57 citations
,
February 1994 in “Experimental dermatology” Melatonin affects mouse skin and may regulate skin functions.
53 citations
,
July 1981 in “Journal of Endocrinology” α-MSH and cyclic AMP boost melanin production, while cyclic GMP and melatonin reduce it.
52 citations
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January 2005 in “International journal of experimental pathology” Melatonin may reduce skin damage caused by X-rays in rats.
52 citations
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October 2004 in “Veterinary dermatology” Melatonin and mitotane treatment led to hair re-growth in 62% of dogs with Alopecia X, but this was not always linked to normal hormone levels.
51 citations
,
January 2004 in “Domestic animal endocrinology” Melatonin implants and long daylight hours alter the timing of hormone release and hair growth in mouflon sheep.
48 citations
,
September 1993 in “The journal of experimental zoology/Journal of experimental zoology” Melatonin treatment started hair growth in goats and affected their hormone levels.
47 citations
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May 1999 in “Reproduction” Goat reproductive activity and coat growth are affected by light and temperature, with temperature altering prolactin levels and hair growth, but not melatonin or estrus onset.
46 citations
,
March 2019 in “Journal of Pineal Research” Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.
46 citations
,
September 2018 in “Expert Opinion on Drug Delivery” Melatonin in special carriers can help treat hair loss.
45 citations
,
February 2019 in “Journal of Affective Disorders” Melatonin improved mental health and metabolism in women with PCOS.
44 citations
,
October 2019 in “International Journal of Molecular Sciences” Melatonin, usually known for sleep regulation, also has antioxidant properties that can protect skin, stimulate hair growth, and improve skin conditions, with topical application being more effective than oral use.