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GlossaryMesenchymal Stem Cells

cells that can become bone, cartilage, or fat cells

Mesenchymal Stem Cells (MSCs) are a type of multipotent stem cell found in various tissues, including bone marrow, fat, and umbilical cord tissue. They have the ability to differentiate into a variety of cell types, such as bone, cartilage, and fat cells, making them valuable for regenerative medicine and tissue engineering.

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research Fully functional hair follicle organ regeneration using organ-inductive potential stem cells with an accessory mesenchymal cell population in an in vitro culture system

February 2026 in “Biochemical and Biophysical Research Communications”

Scientists successfully regenerated functional hair follicles using specific stem cells and mesenchymal cells.

research Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine

88 citations , January 2019 in “Journal of Tissue Engineering and Regenerative Medicine”

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

research Single-cell RNA-seq highlights heterogeneity in human primary Wharton’s jelly mesenchymal stem/stromal cells cultured in vitro

116 citations , April 2020 in “Stem Cell Research & Therapy”

Wharton's jelly stem cells show diverse traits and functions.

Mesenchymal Stem Cells Paracrine Proteins From Three-Dimensional Dynamic Culture System Promoted Wound Healing in Third-Degree Burn Models

research Mesenchymal stem cells paracrine proteins from three‐dimensional dynamic culture system promoted wound healing in third‐degree burn models

July 2023 in “Bioengineering & translational medicine”

Mesenchymal stem cell proteins in a special gel improved healing of severe burns.

Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells

research Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells

42 citations , February 2017 in “Scientific Reports”

Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.

research Modulating Mesenchymal Stem Cell Behavior Using Human Hair Keratin-Coated Surfaces

23 citations , January 2015 in “Stem cells international”

Coating surfaces with human hair keratin improves the growth and consistency of important stem cells for medical use.

research Hair follicular cell/organ culture in tissue engineering and regenerative medicine

21 citations , October 2009 in “Biochemical Engineering Journal”

Stem cell therapy is a promising approach for hair regrowth despite potential side effects.

research From Primary MSC Culture of Adipose Tissue to Immortalized Cell Line Producing Cytokines for Potential Use in Regenerative Medicine Therapy or Immunotherapy

13 citations , October 2021 in “International Journal of Molecular Sciences”

The HATMSC1 cell line from fat tissue can produce helpful factors for regenerative and immune therapies.

research Activating the healing process: three-dimensional culture of stem cells in Matrigel for tissue repair

5 citations , May 2024 in “BMC Biotechnology”

Using Matrigel with stem cells improves tissue healing.

research Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures

58 citations , November 2012 in “PLoS ONE”

Human skin cells can be turned into versatile stem cells, but their ability to do so decreases with repeated use.

research Advances in Stem Cell Therapy: Specific Applications in the Treatment of Cutaneous Radiation Syndrome

8 citations , January 2014 in “Journal of Stem Cell Research & Therapy”

Stem cell therapy improves healing and reduces pain in cutaneous radiation syndrome.

Demethylation of ITGAV Accelerates Osteogenic Differentiation in a Blast-Induced Heterotopic Ossification In Vitro Cell Culture Model

research Demethylation of ITGAV accelerates osteogenic differentiation in a blast-induced heterotopic ossification in vitro cell culture model

11 citations , December 2018 in “Bone”

Removing a methyl group from the ITGAV gene speeds up bone formation in a specific type of bone disease model.

research Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or sub-cultured placental tissue promoted HUVEC angiogenesis in vitro

28 citations , February 2021 in “Stem Cell Research & Therapy”

Placental cell medium boosts blood vessel growth in lab tests.

Conditioned Medium From Primary Cytotrophoblasts, Primary Placenta-Derived Mesenchymal Stem Cells, or Sub-Cultured Placental Tissue Promoted HUVECs Angiogenesis In Vitro

research Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or sub-cultured placental tissue promoted HUVECs angiogenesis in vitro

January 2021

Placental cell medium boosts blood vessel growth in lab tests.

Programmable Viscoelastic Hydrogels Exhibit Antimicrobial and Regenerative Properties to Promote Cell Migration, Wound Healing, and Tissue Remodeling

research Programmable viscoelastic hydrogels exhibit antimicrobial and regenerative properties to promote cell migration, wound healing, and tissue remodeling

April 2026 in “Microsystems & Nanoengineering”

HA-gel-dex hydrogels help heal wounds and regenerate tissue effectively.

In Vitro Cultured Human-Derived HFMSCs Show Potential to Promote Wound Healing

research In vitro cultured human-derived HFMSCs have shown the potential to promote wound

January 2026 in “China National GeneBank DataBase”

Human hair follicle stem cells can help heal wounds faster.

research Epidermal stem cells and skin tissue engineering in hair follicle regeneration

83 citations , January 2015 in “World Journal of Stem Cells”

Hair follicle regeneration needs special conditions and young cells.

research Effects of Hydrogels on Mesenchymal Stem/Stromal Cells Paracrine Activity and Extracellular Vesicles Production

21 citations , March 2025 in “Journal of Extracellular Vesicles”

Hydrogels can enhance stem cell activity, but more research is needed to optimize their use.

research Development of a simple selection protocol for optimizing the harvest of mesenchymal stem cells from explanted human umbilical cord Wharton’s jelly

3 citations , June 2019 in “Asian Journal of Medical Sciences”

A new method improves stem cell harvest from umbilical cords, reducing time and cost.

research Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway

April 2026 in “Frontiers in Cell and Developmental Biology”

Exosomes from stem cells can rejuvenate the scalp and improve hair growth.

research Use of human induced pluripotent stem cell-derived CD271+CD90+ mesenchymal stem cells for the generation of hair inductive dermal cells

September 2016 in “Journal of dermatological science”

Human induced pluripotent stem cells can be used to create cells that help grow hair.

research Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: A new dimension in cell-material interaction

182 citations , June 2017 in “Biomaterials”

Special fiber materials boost the healing properties of certain stem cells.

Platelet Lysate: A Promising Candidate in Regenerative Medicine

research Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system

23 citations , June 2015 in “Journal of Tissue Engineering and Regenerative Medicine”

Wnt1a helps keep cells that can grow hair effective for potential hair loss treatments.

research Hair follicle-derived mesenchymal cells support undifferentiated growth of embryonic stem cells

7 citations , March 2017 in “Experimental and Therapeutic Medicine”

Hair follicle cells can help keep embryonic stem cells undifferentiated.

research 687 BMP signaling in the hair follicle stem cell niche regulates hair growth and skin pigmentation

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

BMP signaling controls hair growth and skin color.