research Activation of the integrated stress response in human hair follicles
Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.
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600-630 / 1000+ results research The influence of biotin on viability, pyruvate carboxylase activity and the response to malate concentration in vitro by isolated secondary hair follicles of the Angora goat
Biotin deficiency may harm hair follicle health and growth in Angora goats.
research Feeding the skin: The emerging role of nutritional intervention in dermatological disorders
Nutrition plays a key role in managing skin disorders, with specific dietary changes helping improve conditions like acne, dermatitis, psoriasis, alopecia, and skin cancer.
research Author response: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression
MFN2 mutations cause mitochondrial problems, leading to more upper body fat and lower leptin levels.
research (798) Finasteride 1 mg: Silent Impacts on Male Fertility Despite Preserved Hormonal Balance
Finasteride 1 mg reduces semen quality without affecting hormones.
research GG01-19 FINASTERIDE 1 MG: SILENT IMPACTS ON MALE FERTILITY DESPITE PRESERVED HORMONAL BALANCE
Finasteride 1 mg/day reduces semen quality without affecting hormones or sexual function.
research Decision letter: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression
MFN2 mutations cause mitochondrial problems, unusual fat distribution, and low leptin despite high body fat.
research Association of common medication with prostate-specific antigen level in 45-year-old German men: Results of the PROBASE trial
Some common medications like metformin, insulin, and ACE inhibitors can lower PSA levels, while statins don't, and low dose finasteride significantly reduces PSA.
research Inhibition of 3‐methylcrotonyl‐CoA carboxylase explains the increased excretion of 3‐hydroxyisovaleric acid in valproate‐treated patients
Valproic acid treatment increases a specific acid in urine by blocking an enzyme, possibly causing skin rash and hair loss.
research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase
Overexpressing a specific enzyme in mice causes hair loss and female infertility.
research Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1 -/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation
Deleting the scd1 gene in mice prevents obesity by disrupting skin lipids and improving heat regulation.
research Mechanism of progesterone neuroprotection of rat cerebellar Purkinje cells following oxygen–glucose deprivation
Progesterone protects rat brain cells by enhancing GABA A receptor activity.
research Biological observations from feeding heated corn oil and heated peanut oil to rats
Rats fed heated oils had less weight gain, more organ damage, and showed signs of toxicity compared to those fed fresh oils.
research Semaglutide Treatment of Excessive Body Weight in Obese PCOS Patients Unresponsive to Lifestyle Programs
Semaglutide helps obese PCOS patients lose weight and improve health.
research In vivo evidence for an increase in 5alpha‐reductase activity in the rat central nervous system following morphine exposure
Morphine increases testosterone breakdown in the rat brain and spinal cord.
research Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice
EGFR hyperactivation increases sebaceous gland size and sebum production in mice.
research Zinc and the Skin
Zinc is vital for skin health and overall body functions, and deficiency can cause serious health issues.
research Long-term dutasteride therapy in men with benign prostatic hyperplasia alters glucose and lipid profiles and increases severity of erectile dysfunction
Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.
research Investigation of the mechanisms of progesterone protection following oxygen–glucose deprivation in organotypic hippocampal slice cultures
Progesterone protects brain cells by converting to allopregnanolone and involving GABAA receptors.
research Dehydroepiandrosterone (DHEA) and Testosterone Concentrations in Human Hair after Chronic DHEA Supplementation
Chronic DHEA supplementation slightly increases testosterone in hair but stays within safe limits.
research Small Molecule Treatments Improve Differentiation Potential of Human Amniotic Fluid Stem Cells
Small molecule treatments improve the ability of human amniotic fluid stem cells to become different cell types.
research Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes
Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, and antioxidants may help treat hair loss.
research Expression profile analysis of dermal papilla cells mRNA in response to WNT10B treatment
WNT10B affects hair growth by altering gene activity in hair cells.
research Vitamin D Resistance and Alopecia
Vitamin D is important for more than just bone health.
research Long-Term Preservation of Rat Skin Tissue by Epigallocatechin-3-O-Gallate
Green tea component EGCG helps keep rat skin grafts viable longer.
research Genetically determined metabolites in allergic conjunctivitis: A Mendelian randomization study
Eight blood metabolites are linked to causing allergic conjunctivitis, offering new ways to predict and treat it.
research TMT-Based Proteomic Explores the Influence of DHEA on the Osteogenic Differentiation of hBMSCs
DHEA boosts bone cell growth and differentiation in elderly stem cells.
research Impact of Testosterone on Hair and Skin
Testosterone can cause acne and male-pattern baldness, affects hair growth in men and women, and makes male skin more sensitive.
research Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women
Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.
research Pu‐erh tea reduces the transmission of CRD‐mediated alopecia risk to offspring
Pu-erh tea reduces hair loss risk in offspring.