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Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

DNA methylation changes in Tan sheep affect growth and fur traits.

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.

Genetic disorders can disrupt mineral and trace element metabolism, affecting health.

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Metabolism plays a key role in determining stem cell fate.

Mitotane changes steroid breakdown, affecting cortisol availability.

Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.

Monilethrix is not caused by a metabolic defect.

Ethylenthiourea is toxic to the liver and nervous system, especially with alcohol.

Phenylalanine may help with depression but can cause issues if not properly processed.

Low-dose methotrexate is generally safe but can cause mild to severe side effects, and folic acid can reduce these risks.

m6A methylation affects the thickness of Alpine Merino wool fibers.

EMT and metabolic pathways help cancer cells resist treatment and spread.

Loss of Dnmt3a and Dnmt3b leads to more aggressive skin tumors, but blocking PPAR-γ can reduce this effect.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Genetic variations greatly affect individual metabolism and can impact health and disease risk.

Inherited color dilution in rabbits is linked to DNA methylation changes.

Decomposed tritiated thymidine is less accurate for DNA tracing, and hair changes can indicate malnutrition.

MK-0773 is a moderate inhibitor of the SRD5A2 enzyme.

Human mitochondrial DNA polymerase makes very few errors, crucial for preventing degenerative diseases.

Selenium deficiency caused symptoms in a child, which improved with selenium supplements.

Mitochondrial dysfunction contributes to ageing by causing DNA mutations and reduced cell function.

Iodine deficiency in lambs causes poor growth, less wool, and delayed sexual maturity.

S-Methylmethionine sulfonium can protect skin from UVB damage.

Aging changes skin cells, leading to different DNA methylation and gene activity, affecting cell metabolism and aging signs.

Recognizing rare causes of MASLD is crucial for effective treatment and preventing complications.