research Microemulsions as a Surrogate Carrier for Dermal Drug Delivery
Microemulsions can effectively deliver drugs through the skin but require careful ingredient selection to avoid irritation.
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research HPLC characterization, molecular docking, QSAR and molecular dynamics simulation of Alstonia boonei phytochemical analogs as potent 5-alpha reductase inhibitors
Alstonia boonei phytochemicals show promise as alternative treatments for BPH with fewer side effects than current drugs.
research 138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles
The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.
research Rational design of keratin-based injectable hydrogels for biomedical applications
Keratin-based hydrogels can be improved for medical use by adding PEG, making them more soluble and adjustable.
research Chitosan-decorated polystyrene-b-poly(acrylic acid) polymersomes as novel carriers for topical delivery of finasteride
Chitosan-decorated polymersomes improve finasteride delivery for hair loss treatment.
research Benzothiazepines, diltiazem and JTV-519, exert an anxiolytic-like effect via neurosteroid biosynthesis in mice
Benzothiazepines like diltiazem reduce anxiety in mice by making neurosteroids.
research Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABAAMiniature IPSCs in Lamina II of the Spinal Cord
Neurosteroids regulate synaptic inhibition in the spinal cord and may help manage spinal pain.
research Determination of cantharidin,nitrogen mustard and minoxidil in nurturing hair products by liquid chromatography-tandem mass spectrometry
research Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry
Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.
research Mesococktails and mesoproducts in aesthetic dermatology
The document concludes that mesotherapy can be effective for skin and hair treatments, but more research is needed to confirm its safety and effectiveness.
research Mitochondrial dysfunction in diabetic neuropathy may be involved in the development of neuropathic pain via a reduction in neurosteroid synthesis
Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.
research Production of biologically active oxidized derivatives of finasteride through metabolism byAspergillus nigerculture
Aspergillus niger culture creates two finasteride derivatives with enzyme-inhibiting effects.
research Enhancement of Dermal Delivery of Finasteride Using MicroemulsionSystems
Microemulsions can improve skin delivery of finasteride.
research Biomimetics through bioconjugation of 16-methylheptadecanoic acid to damaged hair for hair barrier recovery
16-MHA can restore damaged hair's protective barrier and moisture balance.
research 5 alpha-reductase inhibition by a new synthetic steroid (PM-9) in cultures of Penicillium crustosum.
PM-9, like finasteride, may help treat certain diseases by blocking a key enzyme.
research Limits of Visual Detection for Finasteride Polymorphs in Prepared Binary Mixtures: Analysis by X‐ray Powder Diffraction
research Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype
Mirex seems to promote a unique group of skin cells different from those affected by another tumor promoter, TPA.
research Chitosan microparticles for sustaining the topical delivery of minoxidil sulphate
Chitosan microparticles improve minoxidil sulphate delivery, potentially reducing daily applications.
research Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.
research Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach
Mushroom compounds may help treat hair loss better than Finasteride.
research MK-386, an Inhibitor of 5α-Reductase Type 1, Reduces Dihydrotestosterone Concentrations in Serum and Sebum without Affecting Dihydrotestosterone Concentrations in Semen1
MK-386 lowers DHT in blood and skin but not in semen.
research Non-competitive androgen receptor inhibition in vitro and in vivo
Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.
research Development of Novel Cosmetic Base Using Sterol Surfactant. II. Solubilizing of Sparingly Soluble Ultraviolet Ray Absorbers<sup>†</sup>
Sterol surfactants can effectively dissolve UV ray absorbers.
research Stereocontrolled synthesis of all eight stereoisomers of the putative anti-androgen cyoctol
Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.
research De novo designed bifunctional proteins for targeted protein degradation
Newly designed proteins can effectively degrade specific proteins in cells, offering a potential new therapy method.
research Methimazole, Carbimazole, and Congenital Skin Defects
Methimazole may cause skin defects in babies if taken during pregnancy.
research Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice
Genetic mutations that disrupt homocysteine breakdown lead to increased damage in mouse hair keratin.
research Simultaneous LC-MS/MS quantification of glucocorticoids, melatonin and its metabolites in hair
The new method can measure sleep-related hormones in hair effectively and could help track long-term sleep patterns.
research Characterization of spironolactone and metabolites derivatized using Girard's reagent P using mass spectrometry and ion mobility spectrometry
Girard's reagent P improves detection of spironolactone and its metabolites.
research Molecular docking studies and ADME-Tox prediction of phytocompounds from Merremia peltata as a potential anti-alopecia treatment
The compound 16 from the Merremia peltata plant could potentially be a good treatment for hair loss (alopecia) due to its strong activity and favorable skin absorption.