August 2022 in “Journal of the American Academy of Dermatology” The authors agree they didn't discuss the risks of too much micronutrients and value the focus on biotin deficiency signs and treatment effectiveness.
Early biotin treatment can reverse symptoms of congenital biotinidase deficiency.
September 2018 in “PubMed” New strategies like vitamin A and dextromethorphan can help reduce methotrexate side effects and improve patient adherence.
20 citations
,
July 1990 in “Clinical and experimental dermatology” Taking cyproterone acetate and ethinyl oestradiol for hair loss can lower vitamin B12 levels in women.
49 citations
,
April 2007 in “Pediatric Dermatology” Biotin improved hair appearance in uncombable hair syndrome but didn't change hair structure.
14 citations
,
July 2015 in “International Journal of Molecular Sciences” S-Methylmethionine sulfonium can protect skin from UVB damage.
6 citations
,
January 2016 in “Pediatrics international” Japanese infants fed hydrolysate formula may have low biotin levels.
March 2023 in “Mağallaẗ wāsit li-l-ʿulūm wa-al-ṭibb” A rare biotin deficiency in an Iraqi family caused severe symptoms but was successfully treated with lifelong biotin.
16 citations
,
January 2008 in “Acta dermato-venereologica” Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.
August 2018 in “Journal of The American Academy of Dermatology” People with telogen effluvium and scalp discomfort might have low vitamin B12 and could benefit from B12 supplements.
July 2021 in “PARIPEX INDIAN JOURNAL OF RESEARCH” Knuckle darkening can be an early sign of vitamin B12 deficiency.
53 citations
,
March 2003 in “Journal of Investigative Dermatology” Human skin cells have a high-affinity system for biotin transport, crucial for skin health.
8 citations
,
October 2013 in “Chemistry Central Journal” Metabolite 7 is a strong inhibitor for Alzheimer's disease management.
15 citations
,
January 1992 in “Sen'i Gakkaishi” The Cell Membrane Complex in hair has both water-attracting and water-repelling layers.
155 citations
,
August 1991 in “Journal of The American Academy of Dermatology” Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.
21 citations
,
August 1987 in “Archives of Dermatology” High-dose methotrexate can cause severe skin and nail issues.
6 citations
,
May 2014 in “Biomarkers and Genomic Medicine” Charnoly bodies could be a marker for cell damage, and certain nutrients and proteins might prevent them, potentially helping with brain diseases and cancer.
5 citations
,
September 2018 in “International journal of genomics” Genetic mutations that disrupt homocysteine breakdown lead to increased damage in mouse hair keratin.
7 citations
,
July 2021 in “Molecules/Molecules online/Molecules annual” The method can measure vitamin B3 levels in human hair accurately.
6 citations
,
July 2009 in “Biomolecules & therapeutics” Combining MSM with MAP significantly promotes hair growth.
7 citations
,
March 2022 in “The FASEB journal” Adult mice with CBS deficiency show minimal health issues and normal lifespan despite high homocysteine levels.
1 citations
,
February 2025 in “International Journal of Molecular Sciences” HMBi supplementation boosts cashmere growth by affecting specific metabolic and signaling pathways in goats.
February 2026 in “International Journal of Cosmetic Science” The Mito-Activator Complex boosts hair growth by activating mitochondria.
18 citations
,
June 2016 in “Clinical and Experimental Dermatology” Increasing isoleucine intake improved skin and health issues in an infant with maple syrup urine disease.
5 citations
,
August 2015 in “Sultan Qaboos University medical journal” Vitamin B12 deficiency can cause skin darkening and other symptoms, which improve with B12 supplements.
184 citations
,
August 1983 in “The journal of pediatrics/The Journal of pediatrics” Biotinidase deficiency has various symptoms and can be treated with biotin supplements.
1 citations
,
September 2007 in “Neuromuscular disorders” The treatment with valproate, acetylcarnitine, folic acid, and vitamin B12 may improve muscle strength in children with SMA without significant side effects.
1 citations
,
July 2024 in “Cureus” Early recognition of methotrexate toxicity symptoms is crucial.
29 citations
,
July 1996 in “Acta Paediatrica” Biotin should be added to Japanese amino acid formula to prevent deficiency.
January 2024 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” Carbon Quantum Dots can effectively detect cobalt ions and methylcobalamin in water.