research Highlights from the Literature
Apoptosis, not oxidative stress, is linked to aging in mice with mtDNA mutations.
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240-270 / 1000+ resultsresearch Acoustic Fabrication of Collagen–Fibronectin Composite Gels Accelerates Microtissue Formation
Ultrasound helps create gels that speed up tissue formation.
research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation
UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.
research Cross‐linked features of mouse pelage hair resistant to detergent extraction
Two mouse mutants have defective hair cuticle cross-linking.
research Evaluation method of the degree of hair damage. (I). Measurement of tensile strength of human hair by "the multi-point tension test method".
The method accurately measures hair damage and strength, revealing effects of cosmetics and metal correlations.
research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
research Cuticle damage and the tensile properties of human hair
Cuticle damage doesn't affect hair's tensile strength; the cortex is responsible for it.
research Mapping the accessibility of the disulfide crosslink network in the wool fiber cortex
Cysteines in wool fibers are accessible and form important disulfide bonds.
research Effect of shampoo, conditioner and permanent waving on the molecular structure of human hair
Perming significantly changes hair's molecular structure, while shampoo and conditioner do not.
research β1 Integrins with Individually Disrupted Cytoplasmic NPxY Motifs Are Embryonic Lethal but Partially Active in the Epidermis
Mutations in β1 integrins cause embryonic death but have milder effects on skin.
research Dissimilar effects of the hydrophilic carbon dots on the amyloid aggregation of two model proteins and the mechanism discussion
Hydrophilic carbon dots cause one protein to clump more and prevent another from clumping.
research 0950 Exploring hair aging through ex vivo induction of DNA damage and senescence
BrdU speeds up hair follicle aging and reduces hair quality.
research Effect of equilibrium pH on the structure and properties of bleach‐damaged human hair fibers
Hair's structure and properties change with pH; acidic pH maintains strength and less swelling, while alkaline pH increases water content and swelling.
research Scanning Electron Microscopic Study on Collagen Fibrils in the Mink Dermis during the Hair Cycle and Growth
Collagen fibrils in mink skin change structure during hair growth, becoming looser and thicker in the active phase.
research Molecular modeling of hair keratin/peptide complex: Using MM‐PBSA calculations to describe experimental binding results
Electrostatic interactions mainly stabilize the binding of peptides to hair keratin.
research Characterisation of Myotonic Dystrophy type I cell models and drug evaluation by a cell- based quantification platform.
The study on Myotonic Dystrophy type I (DM1) focuses on characterizing cell models and evaluating potential therapies using a cell-based quantification platform. It highlights the roles of DMPK and MBNL1 proteins in DM1 pathology, where misregulation and sequestration lead to disrupted splicing and multisystemic symptoms. The research identifies antisense oligonucleotides (ASOs) as promising therapeutic agents, capable of increasing MBNL1 protein levels without affecting DMPK protein levels. The study underscores the importance of robust in vitro models and advanced techniques like digital droplet PCR and In-Cell Western for drug screening and understanding DM1's complex molecular mechanisms.
research Topographical and Tribological Characteristics of Asian Human Hair Cuticles
Hair damage increases significantly with higher temperatures and longer heating times.
research Impact of acid (”progressive brush”) and alkaline straightening on the hair fiber: Differential effects on the cuticle and cortex properties
Glyoxylic acid straighteners cause more protein loss but have similar hair strength effects as traditional alkaline straighteners.
research Trans glutaminase-mediated cross-linking in mammalian epidermis
research HAIR KERATINIZATION IN HEALTH AND DISEASE
Understanding intermediate filaments helps explain hair health and related diseases.
research Hydrogen Sulfide Disturbs Actin Polymerization via S-Sulfhydration Resulting in Stunted Root Hair Growth
Hydrogen sulfide disrupts protein function and root hair growth in plants by modifying proteins.
research Effects of EGF on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles
EGF makes hair follicles grow longer but stops hair production.
research Cytoskeletal Regulation of Dermal Regeneration
Targeting the actin cytoskeleton could improve skin healing and reduce scarring.
research Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
Chemotherapy causes permanent hair follicle damage by triggering stem cell loss.
research Demethylation of methionine and keratin damage in human hair
Copper and iron cause keratin damage in hair by converting methionine to homocysteine.
research A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity
Keratin is crucial for skin barrier formation and affects mitochondrial function.
research BMP4 and nuclear laminC orchestrate a expression of AHF/Trichohyalin molecule, a key modulator of keratin intermediate filaments in the hair follicle
research The effects of cosmetic treatment on the IEF pattern of human hair keratins.
research Investigation of aging effects in human hair using atomic force microscopy
Aging makes hair thinner and rougher, with less clear edges.
research Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice
Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.