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Did you mean Microphthalmia-associated transcription factor?

GlossaryMicrophthalmia-associated transcription factor

regulates genes for pigment production in skin, hair, and eyes

Microphthalmia-associated transcription factor (MITF) is a protein that plays a crucial role in the development and function of various cell types, including melanocytes, which are responsible for producing the pigment melanin in the skin, hair, and eyes. It regulates the expression of genes involved in cell growth, differentiation, and survival, and mutations in the MITF gene can lead to conditions like Waardenburg syndrome and certain types of albinism.

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research The Suppression Effects of Fat Mass and Obesity Associated Gene on the Hair Follicle-Derived Neural Crest Stem Cells Differentiating into Melanocyte by N6-Methyladenosine Modifying Microphthalmia-Associated Transcription Factor

4 citations , February 2023 in “International Journal of Stem Cells”

The FTO gene hinders stem cells in hair follicles from becoming pigment cells.

research Microphthalmic-associated transcription factor integrates melanocyte biology and melanoma progression.

21 citations , February 2006 in “Clinical Cancer Research”

Mitf plays a key role in melanoma progression and is linked to disease stage.

research Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor

33 citations , January 2015 in “Journal of Ginseng Research”

Ginsenoside Rg3 from Panax ginseng can lighten skin by reducing melanin production.

research Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway

70 citations , December 2004 in “Proceedings of the National Academy of Sciences”

BMP signaling affects hair color by interacting with the MC-1R pathway.

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

July 2023

The human scalp has different types of pigment cells in hair follicles with varying abilities to produce pigment.

research Melanocytes and Vitiligo (and Hair Graying)

1 citations , January 2014 in “Elsevier eBooks”

Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.

research The Peripheral Clock Regulates Human Pigmentation

81 citations , October 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain genes control the color of human hair by affecting pigment production.

Optimization of the Method for Culturing Melanocyte Precursors from Hair Follicles and Their Activation by 1,25-Dihydroxyvitamin D3

research Optimization of the method for the culture of melanocyte precursors from hair follicles and their activation by 1,25-dihydroxyvitamin D3

7 citations , August 2013 in “Experimental and Therapeutic Medicine”

1,25-dihydroxyvitamin D3 helps melanocyte precursors from hair follicles grow and produce melanin, aiding vitiligo treatment understanding.

research Pigmentation Effect of Rice Bran Extract in Hair Follicle-Like Tissue and Organ Culture Models

6 citations , October 2019 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine”

Rice bran extract boosts melanin production in hair follicles.

research Lipid‐mediated signalling and melanocyte function

6 citations , March 2009 in “Pigment Cell & Melanoma Research”

A sphingolipid from human placenta may help treat vitiligo by activating melanocyte stem cells.

research Melanogenesis‐promoting effect of Cirsium japonicum flower extract in vitro and ex vivo

4 citations , October 2021 in “International Journal of Cosmetic Science”

Cirsium japonicum flower extract increases melanin production and could help treat depigmentation conditions.

research Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport

December 2023 in “Journal of ethnopharmacology”

Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.

research Sulfated hyaluronan‐containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles

8 citations , March 2019 in “Journal of Biomedical Materials Research Part A”

Sulfated hyaluronan in collagen helps hair follicle cells grow and develop better for skin grafts.

research Differentiation of CD34+ Human Hair Follicle Stem Cells into Functional Melanocytes

1 citations , December 2018 in “IOP conference series. Materials science and engineering”

CD34+ hair follicle stem cells can become melanin-producing cells for treating skin conditions.

research LB999 Role of transcription factor Ovol2 in skin epithelial regeneration and repair

September 2017 in “Journal of Investigative Dermatology”

Ovol2 is essential for normal skin and hair regeneration.

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22

52 citations , May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

research The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

344 citations , May 2018 in “EMBO journal”

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

research ATP-dependent chromatin remodeling during mammalian development

182 citations , August 2016 in “Development”

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

research Heterogeneity of neural crest-derived melanocytes

8 citations , February 2013 in “Central European Journal of Biology”

Melanocytes are diverse cells important for pigmentation and skin health, influenced by genetics and environment.

research Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles

344 citations , June 2006 in “American Journal Of Pathology”

Human hair follicles can provide stem cells for regenerative medicine.

research Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors

66 citations , December 2014 in “Nature Communications”

Fibroblasts can be turned into melanocytes for potential skin treatments.

SOX2 in the Skin: Roles in Biology and Pathology

research SOX2 in the Skin

1 citations , September 2015 in “Elsevier eBooks”

SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.

Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials

research Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials

41 citations , December 2018 in “Experimental Dermatology”

Understanding how melanocyte stem cells work could lead to new treatments for hair graying and skin pigmentation disorders.

research PAK4 signaling in health and disease: defining the PAK4–CREB axis

81 citations , February 2019 in “Experimental & Molecular Medicine”

PAK4 is crucial in cancer progression, brain development, and could be a therapeutic target, especially through the PAK4-CREB axis.

research Editor's evaluation: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

April 2022

Lhx2 is essential for effective Sonic Hedgehog signaling in early retinal development.

research Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses

73 citations , December 2015 in “Nature Genetics”

Mutations in TBX3 cause horses to have more even hair color instead of Dun camouflage.

research Physiological skin oxygen levels: An important criterion for skin cell functionality and therapeutic approaches

5 citations , June 2024 in “Free Radical Biology and Medicine”

Maintaining natural oxygen levels is crucial for healthy skin cells and effective treatments.

research 432 Patient and device generated variability in platelet-derived growth factors during platelet-rich plasma therapy for hair loss

April 2019 in “Journal of Investigative Dermatology”

Differences in growth factors in platelet-rich plasma therapy for hair loss can vary between patients and can be influenced by the devices used, possibly leading to inconsistent results.

research Association Between Premature Hair Greying and Metabolic Risk Factors: A Cross-sectional Study

5 citations , January 2018 in “Acta dermato-venereologica”

Premature hair greying may indicate a higher risk of metabolic problems.

Platelet-Derived Growth Factor Regulates the Proliferation and Differentiation of Human Melanocytes in a Differentiation-Stage-Specific Manner

research Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner

10 citations , May 2016 in “Journal of Dermatological Science”

PDGF-BB helps young melanocytes grow but stops mature ones from growing, and it makes melanocytes more specialized.