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GlossarymicroRNA

small RNA molecules that regulate gene expression by binding mRNA

MicroRNA (miRNA) are small, non-coding RNA molecules, typically about 22 nucleotides long, that play a crucial role in regulating gene expression. They function by binding to complementary sequences on messenger RNA (mRNA) molecules, leading to mRNA degradation or inhibition of translation, thereby controlling various biological processes, including development, differentiation, and disease.

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research EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression

12 citations , July 2020 in “Aging”

The protein EZH2 blocks microRNA-22, increasing STK40 protein, which helps hair follicle stem cells change and grow hair.

research MicroRNA-22-3p suppresses hair regrowth in androgenetic alopecia by targeting chloride intracellular channel 4

July 2025 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”

MicroRNA-22-3p hinders hair regrowth in male pattern baldness by affecting a specific protein.

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22

52 citations , May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method

research Differential expression analysis of balding and nonbalding dermal papilla microRNAs in male pattern baldness with a microRNA amplification profiling method

29 citations , October 2011 in “British Journal of Dermatology”

Certain microRNAs are more common in balding areas and might be involved in male pattern baldness.

research PLOS Science Wednesday: Hi Reddit, I'm Zhengquan Yu, here to talk about my recent PLOS Genetics paper that has identified the key role of a microRNA in hair loss. I'm joined by Maksim Plikus, who studi

September 2015

MicroRNA miR-22 causes hair loss by making hair follicles regress early.

research Current insight into the functions of microRNAs in common human hair loss disorders: a mini review

22 citations , April 2021 in “Human Cell”

MicroRNAs may help diagnose and treat hair loss disorders.

research Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

research Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles

21 citations , May 2022 in “Frontiers in Cell and Developmental Biology”

Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.

research Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

6 citations , February 2022 in “Journal of immunology research”

Exosomes from fat-derived stem cells can potentially improve hair growth and could be a new treatment for immune-related hair loss.

research Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats

2 citations , July 2025 in “Frontiers in Veterinary Science”

MicroRNAs and AI can improve cashmere goat hair quality and aid in hair disorder diagnosis.

Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets

research Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets

3 citations , May 2022 in “Experimental Dermatology”

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.

research MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development

4 citations , March 2024 in “Cells”

MiR-23b and miR-133 affect sheep hair growth by targeting specific genes.

research Platelet-Rich Plasma Therapy for Telogen Effluvium: A Comprehensive Evaluation of Efficacy and Safety

April 2024

Combining PRP with Tressfix Serum is more effective for hair regrowth in telogen effluvium than using either alone.

research LncRNA-miRNA-mRNA regulatory networks in skin aging and therapeutic potentials

3 citations , October 2023 in “Frontiers in physiology”

ceRNA networks offer potential treatments for skin aging and wound healing.

research MicroRNA-Enriched Exosomes from Different Sources of Mesenchymal Stem Cells Can Differentially Modulate Functions of Immune Cells and Neurogenesis

29 citations , December 2021 in “Biomedicines”

Exosomes from different stem cell sources affect immune cells and brain cell growth differently.

research Hair Follicle-Related MicroRNA-34a Serum Expression and rs2666433A/G Variant in Patients with Alopecia: A Cross-Sectional Analysis

3 citations , April 2022 in “Biomolecules”

Higher miR-34a levels and the A variant of the MIR-34A gene are linked to increased risk and severity of alopecia areata.

research Hair Follicles as Micro-Organs: MicroRNA-Mediated Control of Growth, Cycling, and Fiber Traits

March 2026 in “Biomolecules”

MicroRNAs play a key role in controlling hair growth and quality in sheep and goats.

research The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat

13 citations , September 2018 in “Scientific Reports”

The research found that a complex gene network, controlled by microRNAs, is important for hair growth in cashmere goats.

research MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells

11 citations , May 2023 in “Proceedings of the National Academy of Sciences”

MicroRNA-205 helps hair regrow by making hair follicle stem cells less stiff.

MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata

research MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata

January 2023 in “Annals of dermatology/Annals of Dermatology”

A substance called miR-1246 may help treat severe hair loss by reducing certain immune cell activities.

Detection of Hair MicroRNAs as Novel Potent Biomarkers: Evaluation of Usefulness for Scleroderma Diagnosis

research Detection of hair-microRNAs as the novel potent biomarker: Evaluation of the usefulness for the diagnosis of scleroderma

39 citations , July 2013 in “Journal of dermatological science”

Hair microRNAs could be effective biomarkers for diagnosing scleroderma.

research In-silico cardiac aging regulatory model including microRNA post-transcriptional regulation

3 citations , June 2017 in “Methods”

Researchers created a model to understand heart aging, highlighting the role of microRNAs and identifying key genes and pathways involved.

research The Identification and Characteristics of miRNAs Related to Cashmere Fiber Traits in Skin Tissue of Cashmere Goats

5 citations , February 2023 in “Genes”

Certain miRNAs may influence cashmere fiber traits in goats by affecting hair follicle activities.

research Discovery and Functional Analysis of Secondary Hair Follicle miRNAs during Annual Cashmere Growth

3 citations , January 2023 in “International journal of molecular sciences”

Certain miRNAs play a key role in the growth of cashmere by affecting hair follicle development and regeneration.

research CircERCC6 Positively Regulates the Induced Activation of SHF Stem Cells in Cashmere Goats via the miR-412-3p/BNC2 Axis in an m6A-Dependent Manner

January 2024 in “Animals”

Circular RNA ERCC6 helps activate stem cells important for cashmere goat hair growth by interacting with specific molecules in an m6A modification-dependent way.

research Highway Deconstruction

September 2013 in “Science”

The document concludes that human astrocytes aid stroke recovery, research confidence affects student career aspirations, collagen affects cancer spread, a microRNA suppresses brain cancer growth, calmodulin regulates water channels, and small magnesium pieces deform differently.

research Control by a hair’s breadth: the role of microRNAs in the skin

41 citations , September 2012 in “Cellular and Molecular Life Sciences”

MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.

research MicroRNA/mRNA regulatory networks in the control of skin development and regeneration

56 citations , February 2012 in “Cell Cycle”

MicroRNAs are crucial for controlling skin development and healing by regulating genes.

research Biochemistry of epidermal stem cells

26 citations , July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects”

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

research 202 MicroRNAs in the pathogenesis of male pattern baldness

August 2016 in “Journal of Investigative Dermatology”

Different levels of microRNAs in different parts of the scalp can cause male pattern baldness.