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November 2014 in “Trends in Cell Biology” Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.
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May 2018 in “Journal of Dermatological Science” M2 macrophages, a type of immune cell, help in new hair growth on scars by producing growth factors.
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November 2024 in “eLife” Mesenchymal MEIS2 is essential for whisker development without needing sensory nerves.
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March 2008 in “Journal of biological chemistry/The Journal of biological chemistry” GLI2 increases follistatin production in human skin cells.
Meis2 is essential for whisker development, independent of nerve involvement.
EGF and FGF signaling stops hair follicle development in mice.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” M2 macrophages help hair regrowth in wounds by making growth factors.
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October 2004 in “Experimental Dermatology” α-MSH may help treat skin inflammation and fibrosis.
Mdm2 is crucial for controlling p53 to maintain healthy cells and prevent tumors.
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September 2004 in “Experimental Dermatology” MC-1R is present in skin cells and may help reduce inflammation.
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June 2004 in “Development” FGF signaling is crucial for starting feather development in chicken embryos.
November 2024 in “Journal of Investigative Dermatology” TGF-β signaling is essential for new hair growth after wounds.
March 2026 in “Wound Repair and Regeneration” MARCKSL1 is important for wound healing and could be a target to reduce scarring.
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November 2009 in “Pigment cell & melanoma research” The document concludes that MGRN1 affects mouse fur color by interfering with a receptor's signaling, but its full role in the body is still unknown.
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March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.
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January 2014 in “International Journal of Molecular Sciences” The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.
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December 2017 in “Journal of Investigative Dermatology” Disrupting Notch signaling in blood vessels increases scarring during wound healing in mice.
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March 1998 in “Developmental dynamics” FGFs-4, -8, and -9 have overlapping roles and are repeatedly used in tooth development.
Meis2 is essential for touch sensation and nerve function in mice.
September 2025 in “Digital Commons - RU (Rockefeller University)” Nfib in hair follicle stem cells boosts melanocyte stem cell growth and differentiation.
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March 2015 in “PLOS ONE” Fibroblast Growth Factor-9 (FGF-9) can help improve heart function in diabetic mice after a heart attack by reducing inflammation and harmful changes to the heart's structure.
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September 2003 in “Journal of Investigative Dermatology” Targeting MIG and MCP-1 may help treat inflammation in alopecia areata.
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June 2010 in “The FASEB journal” miR-31 regulates hair growth by controlling gene expression in hair follicles.
August 2023 in “Research Square (Research Square)” Two microRNAs affect hair follicle development in sheep by targeting specific genes.
December 2023 in “Animals” The research found genes and miRNAs that may control hair growth in Forest Musk Deer.