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GlossaryMineralocorticoids

hormones that regulate electrolyte and fluid balance in kidneys

Mineralocorticoids are a type of hormone produced by the adrenal glands, which are located on top of the kidneys. These hormones, such as aldosterone, help regulate the balance of minerals like sodium and potassium in the body, which in turn controls blood pressure and fluid balance. For professionals, it's important to note that mineralocorticoids act primarily on the distal tubules and collecting ducts of the nephron in the kidneys, influencing electrolyte and water reabsorption.

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research Management Approaches to Congenital Adrenal Hyperplasia in Adolescents and Adults; Latest Therapeutic Developments

7 citations , December 2011 in “InTech eBooks”

Glucocorticoid and mineralocorticoid therapy effectively manage Congenital Adrenal Hyperplasia symptoms but have limitations.

research Current Therapeutic Approaches to Chronic Central Serous Chorioretinopathy

13 citations , February 2019 in “Türk oftalmoloji dergisi”

New treatments for chronic central serous chorioretinopathy show promise in preventing permanent vision loss.

research Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance

4 citations , October 2007 in “Dermatologic Clinics”

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

research Chrousos syndrome: from molecular pathogenesis to therapeutic management

47 citations , February 2015 in “European Journal of Clinical Investigation”

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

Management of Congenital Adrenal Hyperplasia During Pregnancy

research Management of CAH during pregnancy

29 citations , December 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity”

With careful management, people with congenital adrenal hyperplasia can have successful pregnancies and become parents.

research Pharmacology of different progestogens: the special case of drospirenone

104 citations , January 2005 in “Climacteric”

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

research Roles of steroid receptors in the lung and COVID-19

9 citations , July 2021 in “Essays in Biochemistry”

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

research Association between Mineralocorticoid Receptor Antagonist and Mortality in SARS-CoV-2 Patients: A Systematic Review and Meta-Analysis

10 citations , March 2022 in “Healthcare”

Mineralocorticoid receptor antagonist therapy does not significantly reduce mortality in COVID-19 patients.

research Mineralocorticoid Receptor Antagonists—A New Sprinkle of Salt and Youth

8 citations , October 2016 in “Journal of Investigative Dermatology”

MR antagonists may improve skin health and wound healing, especially in aging.

research SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism

50 citations , November 2021 in “Viruses”

Spironolactone may help reduce COVID-19 severity in men by blocking harmful effects of certain hormones.

research The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?

40 citations , November 2009 in “Experimental Dermatology”

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

research The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid‐induced impaired wound healing

9 citations , July 2022 in “British Journal of Pharmacology”

Blocking the mineralocorticoid receptor improves wound healing by reducing inflammation and promoting blood vessel growth.

research Profile of the progesterone derivative chlormadinone acetate — Pharmocodynamic properties and therapeutic applications

33 citations , January 2009 in “Contraception”

Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.

research Iatrogenic Cushing's Syndrome in a Patient With Salt-Wasting Congenital Adrenal Hyperplasia (SWCAH)

May 2011 in “Journal of pediatric nursing”

A patient with congenital adrenal hyperplasia improved after adjusting her medication to prevent Cushing's syndrome symptoms.

research Oral medications for central serous chorioretinopathy: a literature review

14 citations , September 2019 in “Eye”

Some oral medications may help treat central serous chorioretinopathy, especially eplerenone, but more research is needed.

Steroid Hormones: Overview and Medical Applications

research Steroid Hormones

3 citations , January 2016 in “Elsevier eBooks”

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

research Effects of natural products on skin inflammation caused by abnormal hormones secreted by the adrenal gland

2 citations , May 2023 in “Frontiers in Pharmacology”

Natural products may help treat skin inflammation from abnormal adrenal hormones.

Muscle Pain in a Woman with Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Resolved with Testosterone Therapy: A Case Report with 10 Years of Follow-Up

research Muscle pain in a woman with congenital adrenal hyperplasia due to 21-hydroxylase deficiency resolved with testosterone therapy. A case report with 10 years of follow-up

February 2026 in “Frontiers in Endocrinology”

Testosterone therapy improved symptoms in a woman with congenital adrenal hyperplasia.

research Progestogens in menopausal hormone therapy

10 citations , January 2015 in “Przeglad Menopauzalny”

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

research Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing

9 citations , June 2021 in “International Journal of Pharmaceutics”

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

research Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo

1 citations , January 2019 in “Skin Pharmacology and Physiology”

Eplerenone, a mineralocorticoid receptor antagonist, was found to promote hair growth in human hair follicles.

research Hormone therapy in acne

24 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

research HORMONAL THERAPY IN DERMATOLOGY

24 citations , January 2001 in “Dermatologic clinics”

Hormonal therapy is a treatment option for acne, the only medical treatment for hirsutism, and the most promising for androgenetic alopecia.

research The role of androgens in hormone replacement therapy

6 citations , September 2005 in “Expert Opinion on Pharmacotherapy”

Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.

research Endocrine disorders and hormonal therapy for adolescent acne

5 citations , May 2017 in “Current Opinion in Pediatrics”

Hormonal therapies are safe and effective for treating acne in female adolescents, with specific treatments for those with endocrine disorders.

research Antiandrogen therapy in hidradenitis suppurativa: finasteride for females

1 citations , July 2021 in “Clinical and Experimental Dermatology”

Finasteride helps reduce hidradenitis suppurativa symptoms in females.

research Androgen replacement therapy in women

1 citations , September 2012 in “Expert Review of Endocrinology & Metabolism”

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

research Navigating the Intersection of Hormonal Therapy and Acne Management in Trans Youth

January 2025 in “ARC Journal of Dermatology”

Transgender youth on hormone therapy need personalized acne treatments and supportive care.

Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

67 citations , August 2007 in “American Journal of Pathology”

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

research Testosterone therapy in men: Clinical and pharmacological perspectives

25 citations , March 2000 in “Journal of Endocrinological Investigation”

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.