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Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1<i>H</i>-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

research iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice

15 citations , December 2014 in “PLoS ONE”

A mutation in the iRhom2 gene causes hairless mice due to abnormal hair follicle development.

research Cloning and Characterization of a Mouse Type I Hair Keratin cDNA

41 citations , December 1988 in “Journal of Investigative Dermatology”

research Expression of an Olfactomedin-Related Gene in Rat Hair Follicular Papilla Cells

10 citations , June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

FP-1 is a key protein in rat hair growth, active only during the growth phase.

research PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands

7 citations , January 2025 in “Journal of Experimental & Clinical Cancer Research”

PRMT5 inhibitors effectively fight adenoid cystic carcinoma in salivary glands.

research Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34

561 citations , April 2003 in “Journal of Investigative Dermatology”

CD34 is a marker for isolating stem-like cells in mouse hair follicles.

research Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10.

33 citations , March 1994 in “PubMed”

High ODC and low K1 and K10 may indicate early skin tumors in mice.

research Linkage of Monilethrix to the Trichocyte and Epithelial Keratin Gene Cluster on 12q11-q13

43 citations , April 1996 in “Journal of Investigative Dermatology”

research Author response: Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

February 2017

Deleting the MAD2L1 gene is tolerated in certain mouse cancer models.

research Functional mapping of the mouse hairless gene promoter region

January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

Researchers found key regions in the mouse hairless gene that control its activity in skin and brain cells, affecting hair follicle function.

research 260 Anti-OX40 monoclonal antibody IMG-007 exhibited clinical activity of hair regrowth, suppressed scalp inflammatory biomarkers in patients with severe alopecia areata in a Ph1b/2a study

November 2025 in “Journal of Investigative Dermatology”

research Cashmere growth control in Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 and decorin genes

7 citations , March 2018 in “Asian-Australasian journal of animal sciences”

OCIAD2 and DCN genes affect hair growth in goats by having opposite effects on a growth signaling pathway and inhibiting each other.

research Charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping

10 citations , November 2017 in “Letters in drug design & discovery”

Researchers identified promising inhibitors for the BRD4 protein, including finasteride and amentoflavone.

Adam10 Haploinsufficiency Causes Freckle-Like Macules in Hairless Mice

research LncRNA MTC enhances the proliferation of Liaoning cashmere goat skin fibroblasts by modulating GSTM1-ASK1 interaction

March 2024 in “Cytologia”

LncRNA MTC boosts growth of goat skin cells, improving cashmere quality.

research Deregulated expression of c-Myc depletes epidermal stem cells

315 citations , June 2001 in “Nature Genetics”

research Identification of Hair Growth Promoting Components in the Kernels of Prunus mira Koehne and Their Mechanism of Action

1 citations , August 2022 in “Molecules”

Prunus mira kernels contain components that can promote hair growth in mice.

research LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis

1 citations , July 2024 in “Journal of Investigative Dermatology”

Immune cells boost stem cell activity in hairy moles, causing more hair growth.

research Keratin 17 Gene Expression during the Murine Hair Cycle

70 citations , March 1997 in “Journal of Investigative Dermatology”

research The abnormal, mis-localizated HR bmh protein associates with members of the protein processing machinery in the cytoplasm

January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

The mutant HR bmh protein mis-localizes in cells, affecting skin and hair development.

research Expression and localization of Sox10 during hair follicle morphogenesis and induced hair cycle

9 citations , January 2021 in “International Journal of Medical Sciences”

Sox10 is important for hair follicle development and hair growth cycles.

research BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin

117 citations , August 1999 in “Nature Genetics”

research The Mask Mutation Identifies TMPRSS6 as an Essential Suppressor of Hepcidin Gene Expression, Required for Normal Uptake of Dietary Iron.

9 citations , November 2007 in “Blood”

TMPRSS6 is crucial for controlling hepcidin and normal iron absorption.

research Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion

April 2012 in “Cancer research”

Blocking mTORC1 may help prevent skin cancer by stopping the growth of certain skin stem cells.

research Skin tumors with matrical differentiation: lessons from hair keratins, beta‐catenin and PHLDA‐1 expression

47 citations , February 2014 in “Journal of Cutaneous Pathology”

Matrical tumors share a common growth mechanism involving the Wnt pathway and consistent PHLDA1 expression.

research Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice.

114 citations , July 2003 in “PubMed”

Lack of KSR1 stops certain skin tumors in mice.

research The fundamentals of WNT10A

6 citations , January 2025 in “Differentiation”

WNT10A is important for tissue development and linked to various human disorders.

research Mrp3, a Mitogen-Regulated Protein/Proliferin Gene Expressed in Wound Healing and in Hair Follicles

19 citations , May 2001 in “Endocrinology”

Mrp3 may aid in wound healing and hair growth.

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