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GlossarymiR-22

regulates gene expression by targeting specific mRNA molecules

miR-22 is a type of microRNA, which are small, non-coding RNA molecules that play a crucial role in regulating gene expression. Specifically, miR-22 has been implicated in various biological processes, including cell differentiation, proliferation, and apoptosis, and has been studied for its potential involvement in conditions like cancer and cardiovascular diseases.

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Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22

52 citations , May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

research miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma

30 citations , August 2021 in “Oncogene”

miR-22 helps skin cancer grow and spread by activating specific cell signals.

research The AR/miR-221/IGF-1 pathway mediates the pathogenesis of androgenetic alopecia

2 citations , January 2023 in “International Journal of Biological Sciences”

A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.

research Ar/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia

January 2022 in “Social Science Research Network”

The Ar/miR-221/IGF-1 pathway is involved in male pattern baldness, with miR-221 potentially being a new target for treatment.

research Exosomal miR-222-3p derived from dermal papilla cells inhibits melanogenesis in melanocytes by targeting SOX10 in rabbits

August 2024 in “Animal Bioscience”

Exosomal miR-222-3p reduces melanin production in rabbits by targeting the SOX10 gene.

research EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression

12 citations , July 2020 in “Aging”

The protein EZH2 blocks microRNA-22, increasing STK40 protein, which helps hair follicle stem cells change and grow hair.

research Hair shaft miRNA‐221 levels as a new tumor marker of malignant melanoma

7 citations , December 2014 in “Journal of dermatology”

Hair shaft miR-221 levels can help detect malignant melanoma.

research MicroRNA-22-3p suppresses hair regrowth in androgenetic alopecia by targeting chloride intracellular channel 4

July 2025 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”

MicroRNA-22-3p hinders hair regrowth in male pattern baldness by affecting a specific protein.

research MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development

4 citations , March 2024 in “Cells”

MiR-23b and miR-133 affect sheep hair growth by targeting specific genes.

research miR-129-5p Participates in Hair Follicle Growth by Targeting HOXC13 in Rabbit

5 citations , April 2022 in “Genes”

miR-129-5p affects hair growth by targeting the HOXC13 gene.

research Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method

research Differential expression analysis of balding and nonbalding dermal papilla microRNAs in male pattern baldness with a microRNA amplification profiling method

29 citations , October 2011 in “British Journal of Dermatology”

Certain microRNAs are more common in balding areas and might be involved in male pattern baldness.

research Current insight into the functions of microRNAs in common human hair loss disorders: a mini review

22 citations , April 2021 in “Human Cell”

MicroRNAs may help diagnose and treat hair loss disorders.

research Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles

21 citations , May 2022 in “Frontiers in Cell and Developmental Biology”

Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.

research Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

6 citations , February 2022 in “Journal of immunology research”

Exosomes from fat-derived stem cells can potentially improve hair growth and could be a new treatment for immune-related hair loss.

Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets

research Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets

3 citations , May 2022 in “Experimental Dermatology”

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.

research Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats

2 citations , July 2025 in “Frontiers in Veterinary Science”

MicroRNAs and AI can improve cashmere goat hair quality and aid in hair disorder diagnosis.

research PLOS Science Wednesday: Hi Reddit, I'm Zhengquan Yu, here to talk about my recent PLOS Genetics paper that has identified the key role of a microRNA in hair loss. I'm joined by Maksim Plikus, who studi

September 2015

MicroRNA miR-22 causes hair loss by making hair follicles regress early.

research Integrated miRNA and mRNA Analysis Provides New Insight into Mechanism of dermal papilla in Androgenetic Alopecia

June 2024 in “Research Square (Research Square)”

Increased cell death and reduced cell growth in hair follicles contribute to baldness.

research The Pathogenesis and Treatment Progress of Androgenic Alopecia

January 2024 in “Journal of Biosciences and Medicines”

Future treatments for androgenic alopecia may focus on reactivating hair follicle stem cells and improving drug delivery.

research Platelet-Rich Plasma Therapy for Telogen Effluvium: A Comprehensive Evaluation of Efficacy and Safety

April 2024

Combining PRP with Tressfix Serum is more effective for hair regrowth in telogen effluvium than using either alone.

research LncRNA-miRNA-mRNA regulatory networks in skin aging and therapeutic potentials

3 citations , October 2023 in “Frontiers in physiology”

ceRNA networks offer potential treatments for skin aging and wound healing.

research COVID-19 Infection Induce miR-371a-3p Upregulation Resulting in Influence on Male Fertility

6 citations , April 2022 in “Biomedicines”

COVID-19 may harm male fertility by affecting sperm production.

N6-Methyladenosine Modification of circRNA-ZNF638 Contributes to the Induced Activation of SHF Stem Cells Through miR-361-5p/Wnt5a Axis in Cashmere Goats

research N6-Methyladenosine modification (m6A) of circRNA-ZNF638 contributes to the induced activation of SHF stem cells through miR-361-5p/Wnt5a axis in cashmere goats

2 citations , November 2022 in “Animal Bioscience”

A specific RNA modification in cashmere goats helps activate hair growth-related stem cells.

research CircERCC6 Positively Regulates the Induced Activation of SHF Stem Cells in Cashmere Goats via the miR-412-3p/BNC2 Axis in an m6A-Dependent Manner

January 2024 in “Animals”

Circular RNA ERCC6 helps activate stem cells important for cashmere goat hair growth by interacting with specific molecules in an m6A modification-dependent way.

research Assessment of the Role of miR‐30a‐5p on the Proliferation and Apoptosis of Hair Follicle Stem Cells

October 2024 in “Journal of Cosmetic Dermatology”

Reducing miR-30a-5p helps hair follicle stem cells grow and survive.

research Hair Follicle-Related MicroRNA-34a Serum Expression and rs2666433A/G Variant in Patients with Alopecia: A Cross-Sectional Analysis

3 citations , April 2022 in “Biomolecules”

Higher miR-34a levels and the A variant of the MIR-34A gene are linked to increased risk and severity of alopecia areata.

research The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat

13 citations , September 2018 in “Scientific Reports”

The research found that a complex gene network, controlled by microRNAs, is important for hair growth in cashmere goats.

research Discovery and Functional Analysis of Secondary Hair Follicle miRNAs during Annual Cashmere Growth

3 citations , January 2023 in “International journal of molecular sciences”

Certain miRNAs play a key role in the growth of cashmere by affecting hair follicle development and regeneration.

research Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation

12 citations , January 2022 in “Cells”

Dermal papilla cell vesicles can boost hair growth genes in fat stem cells.