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GlossaryMixed Cellularity Hodgkin Lymphoma

subtype of cancer with diverse cell types in lymph nodes

Mixed Cellularity Hodgkin Lymphoma (MCHL) is a subtype of Hodgkin lymphoma, a type of cancer that originates in the lymphatic system. It is characterized by the presence of a diverse mix of cell types, including Reed-Sternberg cells, which are a hallmark of Hodgkin lymphoma. This subtype is more common in older adults and often presents with symptoms such as swollen lymph nodes, fever, night sweats, and weight loss.

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$Mitoxantrone, Etoposide, and Prednisolone: A Novel Combination in the Treatment of Relapsed and Refractory Lymphoma$

research Mitoxantrone, Etoposide and Prednisolone—a Novel Combination in The Treatment of Relapsed and Refractory Lymphoma

2 citations , January 1990 in “Leukemia & Lymphoma”

The combination of mitoxantrone, etoposide, and prednisolone is effective for treating relapsed lymphoma with manageable side effects.

Single Best Answers for Hematology Specialist Trainees

research Single Best Answers

January 2016

The document provides 70 multiple choice questions to improve haematology skills.

Section 2: Single Best Answer Questions 51–120

research Section 2: Single Best Answers Questions 51–120

January 2016

The document tests knowledge and decision-making in hematology through multiple-choice questions.

research Research Relevant Conditions and Pathology in Nonhuman Primates

15 citations , January 2020 in “ILAR Journal”

Nonhuman primates are valuable in research but their natural health variations can complicate study results.

research MINOXIDIL FOR MALE-PATTERN BALDNESS

20 citations , September 1987 in “The Lancet”

Physiological Functions of PP2A: Lessons from Genetically Modified Mice

research Physiologic functions of PP2A: Lessons from genetically modified mice

87 citations , July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

research Hemorrhagic cystitis in allogeneic stem cell transplantation: a role for age and prostatic hyperplasia

5 citations , February 2022 in “Supportive Care in Cancer”

Older age is the main risk factor for hemorrhagic cystitis after stem cell transplants.

research Hemorrhagic Cystitis in Allogeneic Stem Cell Transplantation: A Role for Age and Prostatic Hyperplasia

2 citations , October 2021 in “Research Square (Research Square)”

Older age and prostatic hyperplasia in males increase the risk of hemorrhagic cystitis after stem cell transplantation.

research Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90

47 citations , August 2016 in “American Journal Of Pathology”

Fibroblast changes in systemic sclerosis may help understand disease severity and treatment.

research Pohl-Pinkus constrictions of hair following chemotherapy for Hodgkin's disease

8 citations , February 2005 in “British Journal of Haematology”

Chemotherapy caused the patient's hair to have alternating thick and thin segments.

research Two mouse mutations mapped to chromosome 11 with differing morphologies but similar progressive inflammatory alopecia

7 citations , May 2005 in “Experimental Dermatology”

Two mouse mutations cause similar hair loss despite different skin changes.

research Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia

8 citations , January 2013 in “BioMed Research International”

Age, gender, and hair loss affect scalp characteristics differently in young Caucasian adults.

research “Cellularity as a predictive tool for mesenchymal stem cell concentration in bone marrow concentrates: Implications for regenerative medicine”

1 citations , November 2024 in “Bone Reports”

Cellularity can estimate mesenchymal stem cell concentration in bone marrow, aiding regenerative medicine.

research Single-strand DNA breaks in human hair root cells exposed to mobile phone radiation

37 citations , March 2012 in “International Journal of Radiation Biology”

Mobile phone radiation can cause DNA damage in human hair root cells.

research Poly (ɛ‐caprolactone)–chitosan–poly (vinyl alcohol) nanofibrous scaffolds for skin excisional and burn wounds in a canine model

11 citations , January 2018 in “IET Nanobiotechnology”

The scaffolds significantly sped up wound healing in dogs and were safe.

research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

688 citations , June 2007 in “Cell Stem Cell”

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

research Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53

99 citations , August 2009 in “Nature Genetics”

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

Differences in Cell Subsets Between Sun-Exposed and Unexposed Skin: Preliminary Single-Cell Sequencing and Biological Analysis from a Single Case

research Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case

3 citations , October 2024 in “Frontiers in Medicine”

Sun-exposed skin shows different cell activity and gene expression, suggesting targets to prevent skin aging and cancer.

research Laboratory and Experimental Trichology

1 citations , April 2015 in “Current problems in dermatology”

The document concludes that the trichogram is a useful tool for diagnosing hair loss and suggests semi-organ cultures for practical trichological research.

research Wound Healing: A Cellular Perspective

1160 citations , November 2018 in “Physiological Reviews”

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

research Gender-linked differences in human skin

205 citations , July 2009 in “Journal of Dermatological Science”

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Cachexia and Graft-Versus-Host Disease-Type Skin Changes in Keratin Promoter-Driven TNF Alpha Transgenic Mice

research Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.

150 citations , August 1992 in “Genes & Development”

TNF alpha in skin cells causes weight loss, hair and fat issues, and skin inflammation in mice.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Tumor Regression Predicts Higher Risk of Sentinel Node Involvement in Thin Cutaneous Melanomas

research Tumour regression predicts higher risk of sentinel node involvement in thin cutaneous melanomas

68 citations , September 2003 in “British Journal of Dermatology”

Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.

research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

53 citations , September 1999 in “The journal of cell biology/The Journal of cell biology”

K16 can partially replace K14 but causes hair loss and skin issues.

research The Pharmacology of Regenerative Medicine

47 citations , July 2013 in “Pharmacological Reviews”

Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.

research Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction

40 citations , November 2021 in “npj Regenerative Medicine”

Adult spiny mice recover better from heart attacks than common lab mice.

research Leydig Cell Hyperplasia and Adenomas in Mice Treated with Finasteride, a 5α-Reductase Inhibitor: A Possible Mechanism

35 citations , February 1994 in “Fundamental and applied toxicology”

High doses of finasteride cause cell growth and tumors in mice.

research Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis

24 citations , October 2017 in “Biomolecules”

Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.

The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study

research The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study

23 citations , September 2015 in “PLOS ONE”

Mesenchymal stem cells, especially injected into the skin, heal wounds faster and better than chitosan gel or other treatments.